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K. Elayaraja P. Rajesh M.I. Ahymah Joshy V. Sarath Chandra R.V. Suganthi J. Kennedy P.K. Kulriya I. Sulania K. Asokan D. Kanjilal D.K. Avasthi H.K. Varma S. Narayana Kalkura 《Materials Chemistry and Physics》2012
The effect of swift heavy 100 MeV Ag7+ ions irradiation was studied on hydroxyapatite (HAp) thin film prepared by pulsed laser deposition technique (PLD). The GIXRD analysis confirmed the absence of any phase in the HAp phase due to irradiation. In addition, there was a considerable decrease in crystallinity and crystallite size on irradiation. There was no significant variation in the stoichiometry of the irradiated films. Irradiation seemed to decrease the optical band gap energy of HAp thin films. The surface roughness, wettability and bioactivity were improved on irradiation of the samples. Amount of amoxicillin loading/release increased (10%) in ion beam irradiated (1 × 1012 ions cm−2) sample. Irradiated sample showed fast rate of amoxicillin (AMX) release than the pristine. Bactericidal effect was found to increase on irradiation. Surface modified and antibiotics incorporated HAp coated titanium implants may be used to prevent post-surgical infections and to promote bone-bonding of orthopedic devices. 相似文献
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R.V. SuganthiK. Elayaraja M.I. Ahymah JoshyV. Sarath Chandra E.K. GirijaS. Narayana Kalkura 《Materials science & engineering. C, Materials for biological applications》2011,31(3):593-599
The effect of strontium on the crystallization of helical ribbon of hydroxyapatite (HAp) was investigated by single diffusion technique in silica gel matrix at 27 °C and physiological pH. Fibers of HAp were obtained on addition of strontium. The length of the HAp fibers, were found to decrease as the strontium substitution increases. The presence of strontium ion increased the crystallinity as well as crystallite size of HAp. The strontium substituted HAp (Sr-HAp) has similar stoichiometry to that of biological apatite. Sr-HAp was found to have increased surface area (35%) compared to control. Further, strontium substitution leads to an enhancement of in vitro bioactivity. The cumulative in-vitro amoxicillin drug release in phosphate buffer solution (PBS, pH 7.2) showed a prolonged release profile for Sr-HAp. 相似文献
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M.I. Ahymah Joshy K. Elayaraja N. Sakthivel V. Sarath Chandra G.M. Shanthini S. Narayana Kalkura 《Materials science & engineering. C, Materials for biological applications》2013,33(1):466-474
Biodegradable laminated polymer composites of agarose (A), gelatin (G) and hydroxyapatite (HAp) having 3D network of interconnected pores (1–500 μm) were fabricated without using cross linking agents. The incorporation of HAp to A, G and AG had considerable influence on the swelling behaviour, drug release and haemolytic activity. A-HAp scaffolds demonstrated interconnected porosity with extended drug release. G-HAp scaffolds possessed enhanced mechanical property. AG-HAp scaffolds exhibited extended drug delivery, haemocompatibility and efficacy against Gram positive bacteria compared with G-HAp. Hence, AG-HAp composites could be used us a scaffold for tissue engineering and drug delivery system. This method provides non toxic, versatile and cost effective biodegradable scaffolds which could be used for various biomedical applications. 相似文献
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Lan PX Lee JW Seol YJ Cho DW 《Journal of materials science. Materials in medicine》2009,20(1):271-279
Poly(propylene fumarate) (PPF) is an ultraviolet-curable and biodegradable polymer with potential applications for bone regeneration.
In this study, we designed and fabricated three-dimensional (3D) porous scaffolds based on a PPF polymer network using micro-stereolithography
(MSTL). The 3D scaffold was well fabricated with a highly interconnected porous structure and porosity of 65%. These results
provide a new scaffold fabrication method for tissue engineering. Surface modification is a commonly used and effective method
for improving the surface characteristics of biomaterials without altering their bulk properties that avoids the expense and
long time associated with the development of new biomaterials. Therefore, we examined surface modification of 3D scaffolds
by applying accelerated biomimetic apatite and arginine-glycine-aspartic acid (RGD) peptide coating to promote cell behavior.
The apatite coating uniformly covered the scaffold surface after immersion for 24 h in 5-fold simulated body fluid (5SBF)
and then the RGD peptide was applied. Finally, the coated 3D scaffolds were seeded with MC3T3-E1 pre-osteoblasts and their
biologic properties were evaluated using an MTS assay and histologic staining. We found that 3D PPF/diethyl fumarate (DEF)
scaffolds fabricated with MSTL and biomimetic apatite coating can be potentially used in bone tissue engineering. 相似文献
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Jiewei Chen Sean W. King Elayaraja Muthuswamy Anastasia Koryttseva Di Wu Alexandra Navrotsky 《Journal of the American Ceramic Society》2016,99(8):2752-2759
Si–O–C‐based amorphous or nanostructured materials are now relatively common and of interest for numerous electronic, optical, thermal, mechanical, nuclear, and biomedical applications. Using plasma‐enhanced chemical vapor deposition (PECVD), hydrogen atoms are incorporated into the system to form SiOCH dielectric films with very low dielectric constants (k). While these low‐k dielectrics exhibit chemical stability as deposited, they tend to lose hydrogen and carbon (as labile organic groups) and convert to SiO2 during thermal annealing and other fabrication processes. Therefore, knowledge of their thermodynamic properties is essential for understanding the conditions under which they can be stable. High‐temperature oxidative drop solution calorimetry measurement in molten sodium molybdate solvent at 800°C showed that these materials possess negative formation enthalpies from their crystalline constituents (SiC, SiO2, C, Si) and H2. The formation enthalpies at room temperature become less exothermic with increasing carbon content and more exothermic with increasing hydrogen content. Fourier transform infrared spectroscopy (FTIR) spectroscopy examined the structure from a microscopic perspective. Different from polymer‐derived ceramics with similar composition, these low‐k dielectrics are mainly comprised of Si–O(C)–Si networks, and the primary configuration of carbon is methyl groups. The thermodynamic data, together with the structural analysis suggest that the conversion of sp2 carbon in the matrix to surface organic functional groups by incorporating hydrogen increases thermodynamic stability. However, the energetic stabilization by hydrogen incorporation is not enough to offset the large entropy gain upon hydrogen release, so hydrogen loss during processing at higher temperatures must be managed by kinetic rather than thermodynamic strategies. 相似文献
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Vani R Girija EK Elayaraja K Prakash Parthiban S Kesavamoorthy R Narayana Kalkura S 《Journal of materials science. Materials in medicine》2009,20(Z1):S43-S48
A novel, porous triphasic calcium phosphate composed of nonresorbable hydroxyapatite (HAp) and resorbable tricalcium phosphate (alpha- and beta-TCP) has been synthesized hydrothermally at a relatively low temperature. The calcium phosphate precursor for hydrothermal treatment was prepared by gel method in the presence of ascorbic acid. XRD, FT-IR, Raman analyses confirmed the presence of HAp/TCP. The surface area and average pore size of the samples were found to be 28 m2/g and 20 nm, respectively. The samples were found to be bioactive in simulated body fluid (SBF). 相似文献
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Prakash Parthiban S Elayaraja K Girija EK Yokogawa Y Kesavamoorthy R Palanichamy M Asokan K Narayana Kalkura S 《Journal of materials science. Materials in medicine》2009,20(Z1):S77-S83
Thermally stable hydroxyapatite (HAp) was synthesized by hydrothermal method in the presence of malic acid. X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (SEM), differential thermal analysis (DTA), thermogravimetric analysis (TGA) was done on the synthesized powders. These analyses confirmed the sample to be free from impurities and other phases of calcium phosphates, and were of rhombus morphology along with nanosized particles. IR and Raman analyses indicated the adsorption of malic acid on HAp. Thermal stability of the synthesized HAp was confirmed by DTA and TGA. The synthesized powders were thermally stable upto 1,400 degrees C and showed no phase change. The proposed method might be useful for producing thermally stable HAp which is a necessity for high temperature coating applications. 相似文献
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Joy Anjumol Unnikrishnan Gayathri Megha M. Haris M. Thomas Jibu Kolanthai Elayaraja Muthuswamy Senthilkumar 《Journal of Inorganic and Organometallic Polymers and Materials》2022,32(3):912-930
Journal of Inorganic and Organometallic Polymers and Materials - In recent times, the global demand for multi-biofunctional tissue scaffolds is rising gradually. The present study deals with the... 相似文献
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Jothibas M. Bharanidharan K. Paulson E. Elayaraja M. Kumar B. Arun Muthuvel A. 《Journal of Materials Science: Materials in Electronics》2022,33(2):907-919
Journal of Materials Science: Materials in Electronics - In this present work, the pristine and the different percentages of co-doped NiO nanoparticles have been successfully synthesized through... 相似文献
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