A review of the literature on the impact of sexual contacts between adults and boys reveals the existence of two principal outcomes: 1) some participants develop various disorders once in adulthood, such as behavioural problems, sexual disorders, or personality problems; 2) some participants do not present with any major disorders in the long run. These different outcomes may be associated with several moderating variables related to the sexual contacts, such as the level of coercion at the time of these contacts, the bond between the child and the adult, or the context of the sexual relation. However, the conclusions relating to the relations between early sexual contacts with adults and subsequent problems of adaptation in adulthood are difficult to determine. This is because of various methodological problems associated with relevant studies (i.e., definition of these contacts, nature of the sample, method evaluation, statistical analyses). In this article, we propose certain avenues of research that may help clarify this problem. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10−6). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets. 相似文献
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP. 相似文献
High purity multi-walled carbon nanotubes were synthesized from aromatic hydrocarbons (benzene, toluene, xylene and trimethyl benzene) using ferrocene as the source of Fe catalyst. Screening studies of aromatic feeds at 675 °C, residence time of 14 s and Fe/C atom ratio of 1.07%, resulted in feedstock carbon conversion of 20-31%, CNT yield of 19.8-30.5%, and catalyst yield of 5.3-8.3 (g CNT/g catalyst). While the quality of the CNTs as determined by TGA, SEM, TEM and Raman spectroscopy, were high and comparable for different feedstocks; their carbon conversion, CNT yield and catalyst yield differed noticeably. A process optimization study for toluene feed showed that carbon conversion of more than 39%, CNT yield of 38.7% and catalyst yield of 18.3 can be achieved at temperature of 800 °C, Fe/C atom ratio of 0.47%, and residence time of 10-20 s. 相似文献
Gene expression data play a significant role in the development of effective cancer diagnosis and prognosis techniques. However, many redundant, noisy, and irrelevant genes (features) are present in the data, which negatively affect the predictive accuracy of diagnosis and increase the computational burden. To overcome these challenges, a new hybrid filter/wrapper gene selection method, called mRMR-BAOAC-SA, is put forward in this article. The suggested method uses Minimum Redundancy Maximum Relevance (mRMR) as a first-stage filter to pick top-ranked genes. Then, Simulated Annealing (SA) and a crossover operator are introduced into Binary Arithmetic Optimization Algorithm (BAOA) to propose a novel hybrid wrapper feature selection method that aims to discover the smallest set of informative genes for classification purposes. BAOAC-SA is an enhanced version of the BAOA in which SA and crossover are used to help the algorithm in escaping local optima and enhancing its global search capabilities. The proposed method was evaluated on 10 well-known microarray datasets, and its results were compared to other current state-of-the-art gene selection methods. The experimental results show that the proposed approach has a better performance compared to the existing methods in terms of classification accuracy and the minimum number of selected genes.
With the development of online social networking applications, microblogs have become a necessary online communication network in daily life. Users are interested in obtaining personalized recommendations related to their tastes and needs. In some microblog systems, tags are not available, or the use of tags is rare. In addition, user-specified social relations are extremely rare. Hence, sparsity is a problem in microblog systems. To address this problem, we propose a new framework called Pblog to alleviate sparsity. Pblog identifies users’ interests via their microblogs and social relations and computes implicit similarity among users using a new algorithm. The experimental results indicated that the use of this algorithm can improve the results. In online social networks, such as Twitter, the number of microblogs in the system is high, and it is constantly increasing. Therefore, providing personalized recommendations to target users requires considerable time. To address this problem, the Pblog framework groups similar users using the analytic hierarchy process (AHP) method. Then, Pblog prunes microblogs of the target user group and recommends microblogs with higher ratings to the target user. In the experimental results section, the Pblog framework was compared with several other frameworks. All of these frameworks were run on two datasets: Twitter and Tumblr. Based on the results of these comparisons, the Pblog framework provides more appropriate recommendations to the target user than previous frameworks.
Nanoparticles of copper/cuprous oxide (Cu/Cu2 O) were successfully synthesised by a green chemistry route. The synthesis process was carried out using an extract of Stachys lavandulifolia as both reducing and capping agents with a facile procedure. The nanoparticles were characterised by different techniques including X‐ray diffraction, indicating that the synthesised sample comprised both copper and cuprous oxide entity. The nanoparticles had a mean size of 80 nm and represented an impressive bactericidal effect on Pseudomonas aeruginosa.Inspec keywords: copper, copper compounds, nanoparticles, nanofabrication, nanomedicine, antibacterial activity, X‐ray diffractionOther keywords: nanoparticles synthesis, Stachys lavandulifolia, antibacterial activity, green chemistry route, reducing agents, capping agents, X‐ray diffraction, bactericidal effect, Pseudomonas aeruginosa, Cu‐Cu2 O相似文献