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1.
Lauren Folk Kiara Gonzales John Gales Michael Kinsey Elisabetta Carattin Tim Young 《火与材料》2020,44(4):585-606
Practitioners are continuing to develop egress modelling software for the design of the built environment. These models require data about human behaviour and factors for calibration, validation and verification. This study aims to address the specific data and knowledge gap: emergency egress of the elderly. Such data are difficult to collect given privacy and consent concerns, with strong relationships generally being required between residences and researchers. Through the observation of nine fire drills at six Canadian long-term care (LTC) and retirement homes, specific evacuation actions and behaviour were observed for 37 staff members and information about the evacuation of 56 residents was collected. These drills demonstrated that emergency egress in LTC and retirement homes is highly staff dependent with 72% of residents recorded requiring full assistance at all stages of movement in evacuation, and that the type of announced/unannounced drill and level of resident care will affect the type of data collected. The development of travel speed and pre-movement is discussed subject to limitation with qualitative behavioural insights of residents that were observed. This study provides valuable methodological discussion on how to conduct behavioural studies in similar highly restricted research environments. Specific attention is given to understanding the considerations that must be made when using fire drills as data sources, and the impact that these can have on using such data for modelling. This study may inform the initial setup and programming of evacuation models from an actions and behavioural perspectives of staff members and residents. 相似文献
2.
Transport problems typically involve at least two types of constraints, on income and on time. Therefore, the indirect utility
function depends either on the income available after having subtracted the cost of the discrete alternative and on the free
time left after having worked and travelled by each competing option. In the typical linear-in-the-attributes and in-the-parameters
specification, that represents the first grade approximation of the indirect utility function, the effect of income and time
constraints cancel out and only the cost and time of the alternatives matter in the comparison between them. From a microeconomic
point of view this is equivalent to assume that income and time effects could be disregarded; which is not always the case.
To account for these effects the utility function should include second order attributes; however, in non-linear utility functions
it may not be easy to distinguish among several effects that could be relevant: direct preferences for good and leisure, and
simple interactions between attributes other than income and time effects. This paper analyses these effects from a theoretical
point of view focusing on the possible confounding problem in detecting income and time effects. We use a dataset collected
for a modal choice context and containing both revealed and stated preference data, and estimate several NL models examining
the effect of the different second-order terms on detecting income and time effects. We compared specifications including
square cost and time attributes, interactions between time and cost, cost divided by the income available to be spent on free
time, and time multiplied by free time. Our results confirm the strong effect of direct preferences for goods and leisure
time on choice, and the potential confounding effect between quadratic attributes and other non-linear omitted terms. Finally,
we also found that care should be taken in highlighting income and time effects using mixed data sources, since confounding
effects can occur when non-linearities are accounted for in both data sets. 相似文献
3.
Several studies have suggested that primates react differently to spatial reduction. In this article, the authors tested some general hypotheses on primate response to spatial reduction by studying the Apenheul lowland gorillas (Gorilla gorilla gorilla; Apeldoorn, the Netherlands). The frequency of conflicts did not greatly change between the 2 housing settings, thus not supporting the density- aggression model. Indoor, gorillas performed touching behavior more often and increased their level of reconciliation. These findings support the coping model. Indoor, the gorillas also maintained broader interindividual distances by increasing the levels of sitting alone, avoidance, and dismissing behaviors. In conclusion, the Apenheul gorillas modified selectively the distribution of some patterns typical of their behavioral repertoire in response to a high-density condition. Both avoidance and coping tactics were used, thus revealing high levels of behavioral flexibility in this species. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
A. Bianconi Y. Busby M. Fratini V. Palmisano L. Simonelli M. Filippi S. Sanna F. Congiu A. Saccone M. Giovannini S. De Negri 《Journal of Superconductivity and Novel Magnetism》2007,20(7-8):495-501
Here we report synthesis and characterization of high quality samples of the superconducting system Mg1−x
Al
x
B2, with a novel optimized preparation method, in a wide range of Al concentration. All the physical properties of the samples
can be tuned continuously with increasing Al content. We have characterized the samples for their structural, morphological
and magnetic properties with high resolution XRD, SEM-EDS and susceptibility measurements. We have prepared a large number
of Al doped MgB2 in the range 0<x<0.57. All the samples are bulk superconductors and the critical temperature show a smooth and regular behavior as a function
of x.
This work was supported by European project 517039 “Controlling Mesoscopic Phase Separation” (COMEPHS) (2005).
An erratum to this article can be found at 相似文献
5.
Prednisolone therapy of idiopathic feline lower urinary tract disease: a double-blind clinical study
CA Osborne JM Kruger JP Lulich GR Johnston DJ Polzin LK Ulrich J Sanna 《Canadian Metallurgical Quarterly》1996,26(3):563-569
A double-blind clinical study was performed to evaluate prednisolone as treatment for idiopathic feline lower urinary tract disease. No differences in response were observed in prednisolone- and placebo-treated cats. 相似文献
6.
R Caylan A Titiz M Falcioni G De Donato A Russo A Taibah M Sanna 《Canadian Metallurgical Quarterly》1998,118(5):709-713
Experiments were designed to evaluate whether guanosine 3',5'-cyclic monophosphate (cGMP)-mediated mechanisms contribute to vasodilation via propofol in rat mesenteric resistance arteries. Ring segments were suspended in the myograph system for isometric tension recording, and responses to propofol were tested in the presence and absence of methylene blue (MB), an inhibitor of guanylate cyclase. At concentrations > or = 1 microM, propofol caused concentration-dependent relaxation of vessel rings precontracted with U46619 (a thromboxane analog). The effect was not affected by N-monomethyl-L-arginine (L-NMMA; 50 microM). MB (5 microM) reversed propofol-induced vasodilation by 30% (p < 0.001). In contrast, MB has no effect on nifedipine-inhibited vasocontraction. The propofol-induced relaxation was further tested in rings incubated in Ca2+-free solution. U46619-induced contractions were significantly reduced by propofol (40 microM) but not by nifedipine (1 microM). Propofol reduced to a similar degree the contractions obtained to exogenously added calcium chloride in the absence and the presence of MB. Furthermore, propofol (10-100 microM) increased cGMP content in cultured bovine vascular smooth-muscle cells. Soluble guanylate cyclase inhibitors, such as MB and LY83583, attenuated this effect. This investigation suggests that propofol-induced relaxations in small arteries, in addition to inhibition of calcium influx, are mediated by increases of cGMP in the smooth muscle cells. 相似文献
7.
8.
Oliver Schmutzler Sebastian Graf Nils Behm Wael Y. Mansour Florian Blumendorf Theresa Staufer Christian Krnig Dina Salah Yanan Kang Jan N. Peters Yang Liu Neus Feliu Wolfgang J. Parak Anja Burkhardt Elisabetta Gargioni Sabrina Gennis Sharah Chandralingam Finn Heg Wolfgang Maison Kai Rothkamm Florian Schulz Florian Grüner 《International journal of molecular sciences》2021,22(7)
Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time. 相似文献
9.
Francesca Piccotti Ilona Rybinska Elisabetta Scoccia Carlo Morasso Alessandra Ricciardi Lorena Signati Tiziana Triulzi Fabio Corsi Marta Truffi 《International journal of molecular sciences》2021,22(7)
Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery. Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects after demolitive or conservative breast cancer surgery and different procedures have been developed to improve the survival of transplanted fat graft. The regenerative potential of LF is attributed to the multipotent stem cells found in large quantity in adipose tissue. However, a growing body of pre-clinical evidence shows that adipocytes and adipose-derived stromal cells may have pro-tumorigenic potential. Despite no clear indication from clinical studies has demonstrated an increased risk of cancer recurrence upon LF, these observations challenge the oncologic safety of the procedure. This review aims to provide an updated overview of both the clinical and the pre-clinical indications to the suitability and safety of LF in breast oncological surgery. Cellular and molecular players in the crosstalk between adipose tissue and cancer are described, and heterogeneous contradictory results are discussed, highlighting that important issues still remain to be solved to get a clear understanding of LF safety in breast cancer patients. 相似文献
10.
Summary Copolymers containing -S-CO-S-and/or -O-CO-S-groups have been synthesized mainly by interfacial polycondensation.Different chemical structures were obtained by reacting 1,3-benzene dithiol (BDT) respectively with phosgene alone, phosgene and bisphenol-A (BPA), bischloroformate of BPA, BPA polycarbonate oligomers and by reacting phosgene with the products of BPA polycarbonate degraded with BDT. The chemical structures of the copolymers were investigated by IR, 1H-NMR and 13C-NMR; molecular weights were determined by viscometry and vapor pressure osmometry. Although no attempt was made to find the optimum conditions for high molecular weight, some copolymers with fairly high mol. weight were obtained. 相似文献