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The First Principles Study on the Effects of Alloying Element on the Bulk Modulus of TiH 《原子能科学技术》2002,(5)
通过对原子团簇模型进行第一原理计算,研究了过渡合金元素对TiH2体模量的作用.结果显示:随着同一周期各合金元素原子序数的增加,合金化TiH2体系的体模量先增加后减小.ⅤB-ⅧB族合金元素对TiH2的体模量有明显的保持和改善作用,4d元素的这种改善作用强于相应的同族3d元素.合金化TiH2的体模量与体系内合金元素同Ti的键合作用随合金元素的改变有一致的变化趋势,表现出其体性能具有明显的金属性. 相似文献
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NS Zakharova TN Remova IG Bazhanova MH Ozeretskovskaia MV Britsina EI Shmeleva NU Mertsalova EI Ermolova EE Sukhinova VF Bulk AV Sirotinski? AG Poluiianova VV Sviridov IuP Vartanian 《Canadian Metallurgical Quarterly》1997,(3):67-70
A highly effective technology for obtaining a protective antigenic complex, including the main Bordetella pertussis protective antigens (pertussis toxin, filamentous hemagglutinin, agglutinogens, pertactin and adenylate cyclase) and isolated from the supernatant of B. pertussis cultivation medium, has been developed. A new method for the detoxication of antigenic complex which more available to preserve the protective property was suggested. Experimental batches of monovaccine and adsorbed DPT vaccine with the acellular pertussis component, possessing high protective activity and low histamine-sensitizing properties, have been obtained. The stability of protective properties both in liquid and lyophilized acellular pertussis preparations has been noted. 相似文献
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S Mampunza P Verbanck M Verhas P Martin J Paternot O Le Bon C Kornreich A Den Bulk I Pelc 《Canadian Metallurgical Quarterly》1995,95(3):164-169
Review of literature on the seasonality of measles in India reveals that measles occur throughout the year with peaks around March, while October-November are the low transmission months. The epidemics of measles however, occur any time during the year. Nevertheless, measles vaccination campaigns are carried out in India in the Month of March to increase the vaccine coverage levels. Being the low transmission season, October and November may be more appropriate for undertaking measles campaigns in India. 相似文献
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The importance of reducing the systematic error due to non-linearity in N2O flux measurements by static chambers 总被引:1,自引:0,他引:1
P. S. Kroon A. Hensen W. C. M. van den Bulk P. A. C. Jongejan A. T. Vermeulen 《Nutrient Cycling in Agroecosystems》2008,82(2):175-186
Closed (non-steady state) chamber measurements are often used to determine the gas exchange of N2O. Many researchers have addressed the underestimation of the emission estimates obtained from closed chamber measurements
when using linear regression methods. However, the linear regression method is still usually applied to derive the flux. The
importance of using non-linear regression methods is demonstrated with data from four fertilizing events each consisting of
1 month of automatic chamber measurements at Cabauw in the Netherlands in the period from July 2005 to July 2006. It is presented
that the cumulative emission estimates with the exponential regression method are close to the cumulative emissions estimates
with the intercept method. The linear estimates differ by up to 60% of the estimates with the exponential method. The performance
of each method is validated using a C2H6 tracer and a goodness-of-fit analysis. The goodness-of-fit is much better for the exponential than the linear regression
method. The systematic error due to linear regression is of the same order as the estimated uncertainty due to temporal variation.
Therefore, closed-chamber data should be tested for non-linearity and an appropriate method should be used to calculate the
flux.
An erratum to this article can be found at 相似文献
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Guillaume P. Grolez Giorgia Chinig Alexandre Barras Mehdi Hammadi Lucile Noyer Kateryna Kondratska Etmar Bulk Thibauld Oullier Sverine Marionneau-Lambot Marilyne Le Me Stphanie Rtif Stphanie Lerondel Antonino Bongiovanni Tullio Genova Sbastien Roger Rabah Boukherroub Albrecht Schwab Alessandra Fiorio Pla Dimitra Gkika 《International journal of molecular sciences》2022,23(12)
In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa progression because of its impact on cell proliferation, viability, and migration. However, data from the literature are somewhat contradictory regarding the precise role of TRPM8 in prostatic carcinogenesis and are mostly based on in vitro studies. The purpose of this study was to clarify the role played by TRPM8 in PCa progression. We used a prostate orthotopic xenograft mouse model to show that TRPM8 overexpression dramatically limited tumor growth and metastasis dissemination in vivo. Mechanistically, our in vitro data revealed that TRPM8 inhibited tumor growth by affecting the cell proliferation and clonogenic properties of PCa cells. Moreover, TRPM8 impacted metastatic dissemination mainly by impairing cytoskeleton dynamics and focal adhesion formation through the inhibition of the Cdc42, Rac1, ERK, and FAK pathways. Lastly, we proved the in vivo efficiency of a new tool based on lipid nanocapsules containing WS12 in limiting the TRPM8–positive cells’ dissemination at metastatic sites. Our work strongly supports the protective role of TRPM8 on PCa progression, providing new insights into the potential application of TRPM8 as a therapeutic target in PCa treatment. 相似文献
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Dr. Kathrin Brömmel Sarah Maskri Dr. Etmar Bulk Dr. Zoltan Pethő Dr. Marius Rieke Prof. Dr. Thomas Budde Dr. Oliver Koch Prof. Dr. Albrecht Schwab Prof. Dr. Bernhard Wünsch 《ChemMedChem》2020,15(24):2462-2469
The Ca2+ activated potassium channel 3.1 (KCa3.1) is involved in critical steps of the metastatic cascade, such as proliferation, migration, invasion and extravasation. Therefore, a fast and efficient protocol for imaging of KCa3.1 channels was envisaged. The novel fluorescently labeled small molecule imaging probes 1 and 2 were synthesized by connecting a dimethylpyrrole-based BODIPY dye with a derivative of the KCa3.1 channel inhibitor senicapoc via linkers of different length. Patch-clamp experiments revealed the inhibition of KCa3.1 channels by the probes confirming interaction with the channel. Both probes 1 and 2 were able to stain KCa3.1 channels in non-small-cell lung cancer (NSCLC) cells following a simple, fast and efficient protocol. Pre-incubation with unlabeled senicapoc removed the punctate staining pattern showing the specificity of the new probes 1 and 2 . Staining of the channel with the fluorescently labeled senicapoc derivatives 1 or 2 or with antibody-based indirect immunofluorescence yielded identical or very similar densities of stained KCa3.1 channels. However, co-staining using both methods did not lead to the expected overlapping punctate staining pattern. This observation was explained by docking studies showing that the antibody used for indirect immunofluorescence and the probes 1 and 2 label different channel populations. Whereas the antibody binds at the closed channel conformation, the probes 1 and 2 bind within the open channel. 相似文献
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