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排序方式: 共有205条查询结果,搜索用时 15 毫秒
1.
Ewa Olewnik-Kruszkowska Magdalena Gierszewska Sylwia Grabska-Zieliska Joanna Skopiska-Winiewska Ewelina Jakubowska 《International journal of molecular sciences》2021,22(7)
Hydrogels based on chitosan are very versatile materials which can be used for tissue engineering as well as in controlled drug delivery systems. One of the methods for obtaining a chitosan-based hydrogel is crosslinking by applying different components. The objective of the present study was to obtain a series of new crosslinked chitosan-based films by means of solvent casting method. Squaric acid—3,4-dihydroxy-3-cyclobutene-1,2-dione—was used as a safe crosslinking agent. The effect of the squaric acid on the structural, mechanical, thermal, and swelling properties of the formed films was determined. It was established that the addition of the squaric acid significantly improved Young’s modulus, tensile strength, and thermal stability of the obtained materials. Moreover, it should be stressed that the samples consisting of chitosan and squaric acid were characterized by a higher swelling than pure chitosan. The detailed characterization proved that squaric acid could be used as a new effective crosslinking agent. 相似文献
2.
Karolina Bukowska-Strakova Joanna Wodek Ewelina Pitera Magdalena Kozakowska Anna Konturek-Ciela Maciej Ciela Monika Goka Witold Nowak Aleksandra Wieczorek Katarzyna Pawiska-Wsikowska Alicja Jzkowicz Maciej Siedlar 《International journal of molecular sciences》2021,22(3)
Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene (HMOX1) expression is modulated by two polymorphisms in the promoter region: (GT)n-length polymorphism and single-nucleotide polymorphism (SNP) A(−413)T, with short GT repeat sequences and 413-A variants linked to an increased HO-1 inducibility. We found that the short alleles are significantly more frequent in ALL patients in comparison to the control group, and that their presence may be associated with a higher risk of treatment failure, reflecting the role of HO-1 in chemoresistance. We also observed that the presence of short alleles may predispose to develop chemotherapy-induced neutropenia. In case of SNP, the 413-T variant co-segregated with short or long alleles, while 413-A almost selectively co-segregated with long alleles, hence it is not possible to determine if SNPs are actually of phenotypic significance. Our results suggest that HO-1 can be a potential target to overcome the treatment failure in ALL patients. 相似文献
3.
Monika Warat Ewelina Szliszka Ilona Korzonek-Szlacheta Wojciech Król Zenon P. Czuba 《International journal of molecular sciences》2014,15(7):11510-11522
Expression level of Tumor Necrosis Factor—related apoptosis—inducing ligand (TRAIL) receptors is one of the most important factors of TRAIL-mediated apoptosis in cancer cells. We here report for the first time data concerning TRAIL-R1 and TRAIL-R2 receptor expression on RAW264.7 macrophages. Three substances belonging to flavones: chrysin, apigenin and acacetin which differ from their substituents at the 4'' position in the phenyl ring were used in assays because of the variety of biological activities (e.g., anticancer activity) of the polyphenol compounds. The expression of TRAIL-R1 and TRAIL-R2 death receptors on non-stimulated and LPS (lipopolysaccharide)-stimulated macrophages was determined using flow cytometry. We demonstrate that RAW264.7 macrophages exhibit TRAIL-R1 surface expression and that the tested compounds: chrysin, apigenin and acacetin can inhibit TRAIL-R1 death receptor expression level on macrophages. 相似文献
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Renata Rybakiewicz David Djurado Hubert Cybulski Ewelina Dobrzynska Irena Kulszewicz-Bajer Damien Boudinet Jean-Marie Verilhac Malgorzata Zagorska Adam Pron 《Synthetic Metals》2011,161(15-16):1600-1610
New solution processable organic semiconductors, consisting of pyrromelitic, naphthalene or perylene bisimide core and triarylamine N-substituents, have been synthesized. All three compounds are electrochemically active and undergo quasi-reversible oxidation and reduction as evidenced by cyclic voltammetry investigations. The oxidation process involves the transformation of the triarylamine substituents into radical cations as proven spectroscopically and spectroelectrochemically. The reduction process occurs at the arylene bisimide core leading to the formation of a radical anion and eventually a dianion in the second step. These findings are in perfect agreement with the DFT calculations which show that in the synthesized molecules the HOMO orbital is located on the triarylamine moiety whereas the LUMO one on the bisimide core. In all molecules studied the electrochemically determined ionization potential (IP) is slightly higher than 5.0 eV whereas in naphthalene and perylene derivatives the electron affinity (EA) is close to ?3.9 eV. These values fulfill the requirements for n-type (electron) semiconductors in air operating n-channel field effect transistors (FETs) as well as for p-type (hole) conductors in p-channel FETs. To verify whether the newly synthesized compounds exhibit the expected electrical transport properties all organic (CYTOP dielectric) test transistors were fabricated. All three semiconductors showed no field effect in the n-channel configuration. To the contrary, they could be used in p-channel FETs showing, in the saturation regime, the hole mobility approaching 10?4 cm2 V?1 s?1 – the value which slightly exceeds that measured for low molecular weight, amorphous triarylamine semiconductors. 相似文献
6.
Nonisothermal crystallization kinetics of highly‐filled polyolefin composites was studied by means of differential scanning calorimetry (DSC). Two types of commercial calcium carbonate based fillers (modified with stearic acid and nonmodified one) were used for our investigations. In order to evaluate the crystallization kinetics changes of composites, the Avrami theory modified by Jeziorny was used. Validity of mineral fillers modification with stearic acid has been proved by thermal analysis. Because of the suppression of the heterogeneous nucleation effect resulting from calcium carbonate with stearic acid modification, an increase in the processability of highly‐filled polyolefin cast films might occur. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 41201. 相似文献
7.
Janusz Blasiak Ewelina Synowiec Antero Salminen Kai Kaarniranta 《International journal of molecular sciences》2012,13(10):13378-13397
The pathogenesis of age-related macular degeneration (AMD) is complex and involves interactions between environmental and genetic factors, with oxidative stress playing an important role inducing damage in biomolecules, including DNA. Therefore, genetic variability in the components of DNA repair systems may influence the ability of the cell to cope with oxidative stress and in this way contribute to the pathogenesis of AMD. However, few reports have been published on this subject so far. We demonstrated that the c.977C>G polymorphism (rs1052133) in the hOGG1 gene and the c.972G>C polymorphism (rs3219489) in the MUTYH gene, the products of which play important roles in the repair of oxidatively damaged DNA, might be associated with the risk of AMD. Oxidative stress may promote misincorporation of uracil into DNA, where it is targeted by several DNA glycosylases. We observed that the g.4235T>C (rs2337395) and c.–32A>G (rs3087404) polymorphisms in two genes encoding such glycosylases, UNG and SMUG1, respectively, could be associated with the occurrence of AMD. Polymorphisms in some other DNA repair genes, including XPD (ERCC2), XRCC1 and ERCC6 (CSB) have also been reported to be associated with AMD. These data confirm the importance of the cellular reaction to DNA damage, and this may be influenced by variability in DNA repair genes, in AMD pathogenesis. 相似文献
8.
Matylda Jakubowska 《热应力杂志》2013,36(3-4):259-283
Kirchhoff's type formula for a solution of a central system of field equations of thermoelasticity with finite wave speeds is established in the paper. The solution of the system (φ, θ), where φ and θ denote the thermoelastic displacement potential and temperature respectively, is expressed by surface integrals over the boundary of a thermoelastic solid whose kernels have the form of infinite series involving Bessel functions. Application of the formula to reduce the solution of an initial-boundary problem to that of a vector Fredholm integral equation of the first kind is outlined. 相似文献
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