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N Pasetto V Petrozza C Ticconi A Zicari F Carpino E Piccione M Melis 《Canadian Metallurgical Quarterly》1993,35(2):99-102
Ten patients with biopsy verified chronic hepatitis C virus (HCV) infection were treated with oral ribavirin at a dose of 1,000-1,200 mg per day in two divided doses for 12 weeks. Serum alanine aminotransferase (ALT) levels and hepatitis C viral ribonucleic acid (RNA) levels in serum were followed prior to, during, and 12 weeks posttreatment. ALT levels decreased significantly in all patients during therapy from a mean level of 3.21 mukat/l (range 1.22 to 7.79) before, to 1.25 mukat/l (range 0.78 to 2.04) at the end of treatment (P < 0.005). Hereafter, relapse to pretreatment levels was seen within 12 weeks after treatment stop. The hepatitis C viral RNA levels decreased from a mean 10 log titer of 4.1 (range 1-6) before treatment to 3.4 (range 1-5) at treatment stop. Five patients did not change their HCV RNA titers during treatment. Twelve weeks posttreatment only 3 patients had lower titers than prior to treatment. We conclude that oral ribavirin seems to reduce the viral load, at least temporarily, in some patients with chronic viremic HCV infection. Further studies are needed to evaluate fully the effect of oral ribavirin on chronic HCV infection. 相似文献
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V. K. Arya M. E. Melis G. R. Halford 《Fatigue & Fracture of Engineering Materials & Structures》1991,14(10):967-977
Results are presented of elastic, elastic-plastic and elastic-plastic-creep analyses of an actively cooled cowl lip. A cowl lip is part of the leading edge of an engine inlet of proposed hypersonic aircraft and is subject to severe thermal loadings and gradients during flight. Values of stresses calculated by elastic analysis are well above the yield strength of the cowl lip material. Such values are highly unrealistic, and thus elastic stress analyses are inappropriate. The inelastic (elastic-plastic and elastic-plastic-creep) analyses produce more reasonable and acceptable stress and strain distributions in the component. Finally, using the results from these analyses, predictions are made for the cyclic crack initiation life of a cowl lip. A comparison of predicted cyclic lives shows the cyclic life prediction from the elastic-plastic-creep analysis to be the lowest and, hence, most realistic. 相似文献
5.
W. Ming F. Melis R. D. van de Grampel L. van Ravenstein M. Tian R. van der Linde 《Progress in Organic Coatings》2003,48(2-4):316-321
Self-stratification strategy can be used to prepare films in which both bulk and surface properties can be optimized. By using this approach, only a very small quantity of fluorinated species is needed to generate a surface with low surface energy. When cross-linking is involved during film formation, we are dealing with a competition behavior between the diffusion of fluorinated species and the formation of cross-linked network. In this study low surface energy polymeric films were prepared on the basis of partially fluorinated polyisocyanates, in combination with hydroxyl-end-capped three-armed solventless liquid oligoesters and modified hyperbranched polyesters. At a fluorine concentration of only 0.5 wt.%, contact angles of water and hexadecane can reach 120° and 80°, respectively. A surface energy as low as 10–15 mN/m can be obtained upon the addition of less than 1 wt.% of fluorine in the films. It was shown, from real time ATR-FTIR and contact angle measurements, that the curing temperatures demonstrated significant effects on the cross-linking rate as well as on the wettability of the films. 相似文献
6.
. Murat Dogan B. Zü htü Uysal John R. Grace 《Chemical Engineering Communications》2004,191(4):566-579
Experiments were carried out in a half slot-rectangular spouted bed to investigate the effects of slot width and lower section basal angle on column hydrodynamics. Flow regimes, minimum spouting velocity, spouting and maximum pressure drops, and maximum spoutable bed height were determined for 4 mm diameter polyethylene particles. The results are compared with those for conventional cylindrical and rectangular spouted beds. Correlations for each hydrodynamic parameter are developed and compared with equations available in the literature. 相似文献
7.
In many wireless sensor network (WSN) applications, the location of a sensor node is crucial for determining where the event or situation of interest occurred. Therefore, localization is one of the critical challenges in WSNs. Mobile anchor node assisted localization (MANAL) is one of the promising solutions for the localization of statically deployed sensors. The main problem in MANAL localization is that the path planning of the mobile anchor (MA) node should be done so that the localization error in the network will be minimal and that all unknown nodes in the network are covered. This paper proposes a new path planning approach called nested hexagons curves (NHexCurves) for MANAL. NHexCurves guarantees that it will receive messages from at least three non-collinear anchors to locate all unknown nodes in the network. The proposed model has compared six different path planning schemes in the literature using weighted centroid localization (WCL). In these comparisons, first of all, localization errors of the models are compared using some statistical concepts. Second, the variation of the localization error according to parameters such as resolution (R) and the standard deviation of noise (σ) is observed. Then, with similar approaches, the standard deviation of errors, localization ratio, scalability performances, and finally, path lengths of the models are examined. The simulation results show that the NHexCurves static path planning model proposed in this study stands out compared to other models with high localization error and localization ratio performance, especially at low resolutions, due to its path design. At the same time, the lowest error values according to σ are obtained with the proposed model among all models considered. 相似文献
8.
Most of the published literature on robust design is basically concerned with a single response. However, the reality is that common industrial problems usually involve several quality characteristics, which are often correlated. Traditional approaches to multidimensional quality do not offer much information on how much better or worse a process is when finding optimal settings. Köksoy and Fan [Engineering Optimization 44 (8): 935–945] pointed out that the upside-down normal loss function provides a more reasonable risk assessment to the losses of being off-target in product engineering research. However, they only consider the single-response case. This article generalizes their idea to more than one response under possible correlations and co-movement effects of responses on the process loss. The response surface methodology has been adapted, estimating the expected multivariate upside-down normal loss function of a multidimensional system to find the optimal control factor settings of a given problem. The procedure and its merits are illustrated through an example. 相似文献
9.
Kay-Arne Walther Jos Roberto Gonzales Sabine Grger Benjamin Ehmke Dogan Kaner Katrin Lorenz Peter Eickholz Thomas Kocher Ti-Sun Kim Ulrich Schlagenhauf Raphael Koch Jrg Meyle 《International journal of molecular sciences》2022,23(13)
Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov =ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression. NCT00707369相似文献
10.
摘译 近年来,作为一种高能量带隙半导体,二氧化钛(TiO2)由于在紫外光照射下具有良好的光催化活性,已引起科研人员的广泛关注.由于TiO2无色透明,具有广泛的应用前景,如薄的TiO2涂层可用于创建自清洁、防雾、超亲水表面.同时,也能用于太阳能电池等光电子行业.
化学溶液沉积法因具有相对简单的大面积生产工艺,且较低的制膜成本和高可用性,成为TiO2薄膜制备常用的方法之一.针对另一种TiO2制备方法,即溶胶凝胶法,大量研究文献主要关注乙醇的水解控制.然而,工业需求鼓励开发水基前驱设计.其难度在于钛醇盐与水的高反应性.在有机介质中,加入少量的水往往导致水解.因此,需要采用络合剂作为稳定剂,阻止纯水中的水解反应和避免由此产生的产物沉淀. 相似文献