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排序方式: 共有1070条查询结果,搜索用时 343 毫秒
1.
Safa Meraghni Labib Sadek Terrissa Meiling Yue Jian Ma Samir Jemei Noureddine Zerhouni 《International Journal of Hydrogen Energy》2021,46(2):2555-2564
Prognostics and health management of proton exchange membrane fuel cell (PEMFC) systems have driven increasing research attention in recent years as the durability of PEMFC stack remains as a technical barrier for its large-scale commercialization. To monitor the health state during PEMFC operation, digital twin (DT), as a smart manufacturing technique, is applied in this paper to establish an ensemble remaining useful life prediction system. A data-driven DT is constructed to integrate the physical knowledge of the system and a deep transfer learning model based on stacked denoising autoencoder is used to update the DT with online measurement. A case study with experimental PEMFC degradation data is presented where the proposed data-driven DT prognostics method has applied and reached a high prediction accuracy. Furthermore, the predicted results are proved to be less affected even with limited measurement data. 相似文献
2.
Jasmin Kuhn Philipp M. Klein Nader Al Danaf Joel Z. Nordin Sren Reinhard Dominik M. Loy Miriam Hhn Samir El Andaloussi Don C. Lamb Ernst Wagner Yoshitsugu Aoki Taavi Lehto Ulrich Lchelt 《Advanced functional materials》2019,29(48)
Phosphorodiamidate morpholino oligomers (PMOs) are oligonucleotide analogs that can be used for therapeutic modulation of pre‐mRNA splicing. Similar to other classes of nucleic acid‐based therapeutics, PMOs require delivery systems for efficient transport to the intracellular target sites. Here, artificial peptides based on the oligo(ethylenamino) acid succinyl‐tetraethylenpentamine (Stp), hydrophobic modifications, and an azide group are presented, which are used for strain‐promoted azide‐alkyne cycloaddition conjugation with splice‐switching PMOs. By systematically varying the lead structure and formulation, it is determined that the type of contained fatty acid and supramolecular assembly have a critical impact on the delivery efficacy. A compound containing linolenic acid with three cis double bonds exhibits the highest splice‐switching activity and significantly increases functional protein expression in pLuc/705 reporter cells in vitro and after local administration in vivo. Structural and mechanistic studies reveal that the lipopeptide PMO conjugates form nanoparticles, which accelerate cellular uptake and that the content of unsaturated fatty acids enhances endosomal escape. In an in vitro Duchenne muscular dystrophy exon skipping model using H2K‐mdx52 dystrophic skeletal myotubes, the highly potent PMO conjugates mediate significant splice‐switching at very low nanomolar concentrations. The presented aminoethylene‐lipopeptides are thus a promising platform for the generation of PMO‐therapeutics with a favorable activity/toxicity profile. 相似文献
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4.
Rami Langar Samir Tohme Nizar Bouabdallah 《International Journal of Network Management》2006,16(4):279-294
Multi‐Protocol Label Switching (MPLS) is deployed in the Internet backbone to support service differentiation and traffic engineering. In recent years, there has been interest in extending the MPLS capability to wireless access networks for mobility management support. In this paper, we present analysis of Micro Mobile MPLS, a new micro‐mobility management scheme which integrates the Mobile IP and MPLS protocols by using two‐level hierarchy architecture. Our proposal supports two protocol variants. First, the fast handoff process, which anticipates the LSP procedure set‐up with neighboring locations where a mobile node (MN) may move to, is provided to reduce service disruption. Second, a new mechanism based on the forwarding chain concept is proposed to track efficiently the host mobility within a domain. This concept can significantly reduce registration update costs and provide low handoff latency. Analytical models are developed and simulations are conducted to justify the benefits of our proposed mechanisms. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
5.
Charbel Farhat Ulrich Hetmaniuk 《International journal for numerical methods in engineering》2002,54(9):1309-1332
We present a fictitious domain decomposition method for the fast solution of high‐frequency acoustic scattering problems characterized by a partially axisymmetric sound‐soft scatterer. We apply this method to the solution of various mockup submarine problems, and highlight its computational advantages and intrinsic parallelism. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
6.
This paper presents the development of an optimization and a computer-simulation model to evaluate the process plans of a manufacturing center by analyzing the effect of tool failure on system performance. The GPSS/PC simulation program that is used in this study has been built with variables, functions and matrices so that many experiments could be conducted with the model. Sensitivity analysis is presented and the developed model has proven to be useful in determining optimum sequencing of parts for various operating policies. 相似文献
7.
We present a fictitious domain decomposition method for the fast solution of acoustic scattering problems characterized by a partially axisymmetric sound‐hard scatterer. We apply this method to the solution of a mock‐up submarine problem, and highlight its computational advantages and intrinsic parallelism. A key component of our method is an original idea for addressing a Neumann boundary condition in the general framework of a fictitious domain method. This idea is applicable to many other linear partial differential equations besides the Helmholtz equation. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
8.
9.
Charbel Farhat Michel Lesoinne 《International journal for numerical methods in engineering》1993,36(5):745-764
Most of the recently proposed computational methods for solving partial differential equations on multiprocessor architectures stem from the 'divide and conquer' paradigm and involve some form of domain decomposition. For those methods which also require grids of points or patches of elements, it is often necessary to explicitly partition the underlying mesh, especially when working with local memory parallel processors. In this paper, a family of cost-effective algorithms for the automatic partitioning of arbitrary two- and three-dimensional finite element and finite difference meshes is presented and discussed in view of a domain decomposed solution procedure and parallel processing. The influence of the algorithmic aspects of a solution method (implicit/explicit computations), and the architectural specifics of a multiprocessor (SIMD/MIMD, startup/transmission time), on the design of a mesh partitioning algorithm are discussed. The impact of the partitioning strategy on load balancing, operation count, operator conditioning, rate of convergence and processor mapping is also addressed. Finally, the proposed mesh decomposition algorithms are demonstrated with realistic examples of finite element, finite volume, and finite difference meshes associated with the parallel solution of solid and fluid mechanics problems on the iPSC/2 and iPSC/860 multiprocessors. 相似文献
10.
T. Jeevananda Siddaramaiah Taek Su Lee Joong Hee Lee O. M. Samir R. Somashekar 《应用聚合物科学杂志》2008,109(1):200-210
Polyaniline/carboxylated multi-walled carbon nanotube (PAni/c-MWNT) nanocomposites have been synthesized by micellar aided emulsion polymerization with various c-MWNTs compositions, viz., 0.5, 1, 5, and 10 wt %. The microcrystalline parameters such as the nanocrystal size (〈N〉), lattice strain (g), interplanar distance (dhkl), width of the crystallite size distribution, surface weighted crystal size (Ds), and volume of the ordered regions were calculated from the X-ray data by using two mathematical models, namely the Exponential distribution and Reinhold distribution methods. The effects of heat ageing on the microcrystalline parameters of the PAni/c-MWNT nanocomposites were also studied and the results are correlated. The thermal stability and electrical resistivity of the PAni/c-MWNT nanocomposites were examined with thermogravimetric analysis (TGA) and a conventional two-probe method. The TGA data indicate that the thermal stability of the nanocomposites improved after the incorporation of c-MWNTs. The influence of temperature on the resistivity of the nanocomposites was also measured. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci 2008 相似文献