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排序方式: 共有322条查询结果,搜索用时 156 毫秒
1.
Lydia Saidi Dr. Djenisa H. A. Rocha Dr. Oualid Talhi Dr. Yamina Bentarzi Prof. Dr. Bellara Nedjar-Kolli Dr. Khaldoun Bachari Dr. Filipe A. Almeida Paz Dr. Luisa A. Helguero Prof. Dr. Artur M. S. Silva 《ChemMedChem》2019,14(10):1041-1048
Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones through 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single-crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA-MB-231 and T47-D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC50 values ranging from 12.09 to 26.49 μm ) and induced cell-cycle retardation only on prostate cancer cells, which suggested that it might exert cell-type-specific effects. 相似文献
2.
Strains of Bacteroides fragilis associated with diarrheal disease (enterotoxigenic B. fragilis) produce a 20-kDa zinc-dependent metalloprotease toxin (B. fragilis enterotoxin; BFT) that reversibly stimulates chloride secretion and alters tight junctional function in polarized intestinal epithelial cells. BFT alters cellular morphology and physiology most potently and rapidly when placed on the basolateral membrane of epithelial cells, suggesting that the cellular substrate for BFT may be present on this membrane. Herein, we demonstrate that BFT specifically cleaves within 1 min the extracellular domain of the zonula adherens protein, E-cadherin. Cleavage of E-cadherin by BFT is ATP-independent and essential to the morphologic and physiologic activity of BFT. However, the morphologic changes occurring in response to BFT are dependent on target-cell ATP. E-cadherin is shown here to be a cellular substrate for a bacterial toxin and represents the identification of a mechanism of action, cell-surface proteolytic activity, for a bacterial toxin. 相似文献
3.
N. Souami D. Saidi M. Negache A. Ati 《Journal of Materials Engineering and Performance》2003,12(6):715-720
Martensitic 12% chromium stainless steel is generally used for the manufacture of water vapour turbine blades. This material,
under these environmental conditions, develops fatigue corrosion with failure as a result of the segregation of certain constituent
elements such as phosphorus (P) and sulphur (S),[1–3] or the presence of some types of inclusions.[2–4] To be able to understand and explain these phenomena, in situ characterization of the fractured surfaces were performed for
two types of samples: steel 1 as manufactured turbine material whose fracture mode is intergranular and steel 2 issued from
last stage turbine blades after 100 000 h service at 40 °C whose fracture mode is transgranular. The techniques used for characterization
were scanning electron microscopy (SEM) coupled with the x-ray analysis by energy dispersive spectroscopy (EDS), and auger
electron spectroscopy (AES). The Auger results enabled the understanding of the brittle to ductile transition for the material
by showing the simultaneous diffusion of carbon from grain boundaries (GB) to grains (G) and chromium from G to GB. Furthermore,
the heavy segregation of phosphorus at the GBs could explain the intergranular crack rupture traces observed in steel 2. SEM
observations coupled with EDS analysis showed the presence of different types of non-metallic inclusions such as silicon-based
complex inclusions and manganese sulfides (MnS). The presence of silicon-based complex inclusions at GB could explain the
intergranular fracture mode previously reported. The characterization of the fracture appearance suggests also that MnS inclusions
can act as nucleation sites for secondary microcracks at the GB level that were observed after service. 相似文献
4.
Morteza Sadeghi Arman Sadeghi Mohammad Hassan Saidi 《Microfluidics and nanofluidics》2014,16(1-2):207-224
Consideration is given to the buoyancy effects on the fully developed gaseous slip flow in a vertical rectangular microduct. Two different cases of the thermal boundary conditions are considered, namely uniform temperature at two facing duct walls with different temperatures and adiabatic other walls (case A) and uniform heat flux at two walls and uniform temperature at other walls (case B). The rarefaction effects are treated using the first-order slip boundary conditions. By means of finite Fourier transform method, analytical solutions are obtained for the velocity and temperature distributions as well as the Poiseuille number. Furthermore, the threshold value of the mixed convection parameter to start the flow reversal is evaluated. The results show that the Poiseuille number of case A is an increasing function of the mixed convection parameter and a decreasing function of the channel aspect ratio, whereas its functionality on the Knudsen number is not monotonic. For case B, the Poiseuille number is decreased by increasing each of the mixed convection parameter, the Knudsen number, and the channel aspect ratio. 相似文献
5.
In the present article, higher-order shear and normal deformable plate theory together with modified couple stress theory are developed to study the bending analysis of thick functionally graded rectangular micro-plates. One material length scale parameter is used for capturing the size effects. Utilizing the variational approach and also a principle of virtual displacement, a new form of equilibrium equations and the corresponding boundary conditions are derived. It is assumed that material properties vary through the thickness according to the power law function. Finally, an analytical solution for the bending problem of a simply supported FG rectangular micro-plate is presented. 相似文献
6.
Minou Kouh Soltani Sohrab Khanmohammadi Farzan Ghalichi Farrokh Janabi-Sharifi 《International Journal of Control, Automation and Systems》2017,15(1):54-63
Minimally invasive steerable catheters, commonly implemented in cardiac ablation, are currently operated by interventionalists exposing them to X-ray radiation and requiring the dexterity for accurate steering. To conduct robot-assisted cardiac ablation, highly accurate stable control platform for precise force/position control on the moving tissue is required. This paper introduces hybrid force/position control strategy to apply a constant force to the cardiac tissue while tracking the desired trajectory. The position controller is based on a nonlinear model predictive tracking control satisfying the input constraints. Cosserat rod theory is incorporated for the distal shaft modeling of tendon-driven catheters, and the model is reformulated for controller design and stability proof. Lyapunov-based stability analysis is conducted. To apply the controller, the force-displacement mapping of the cardiac tissue is obtained through ex vivo experimental tests. The performance of the controller is evaluated, and the catheter is capable of regulating the force with the RMSE of 4.9 mN and tracking the position with the RMSE of 0.89 mm. The promising results verify the potential of the application of the introduced approach in real applications including in vitro and clinical cardiac ablation. 相似文献
7.
8.
In this research, the effect of NbF5 as an additive on the hydrogen desorption kinetics of MgH2 was investigated and compared to TiH2, Mg2Ni and Nb2O5 catalysts. The kinetics measurements were done using a method in which the ratio of the equilibrium plateau pressure to the opposing pressure was the same for all the reactions. The data showed NbF5 to be vastly superior to the other catalysts for improving the desorption kinetics of MgH2. The rates of desorption were found to be in the order NbF5 ? Nb2O5 > Mg2Ni > TiH2 > Pure MgH2. Kinetic modeling measurements showed that chemical reaction at the phase boundary to be the likely process controlling the reaction rates. TPD analyses showed the mixture with NbF5 has the lowest desorption temperature although it was accompanied with some weight penalty. 相似文献
9.
Abouelkacem Qaiss Hassan Saidi Omar Fassi‐Fehri Mosto Bousmina 《Polymer Engineering and Science》2012,52(12):2637-2644
Cellular polypropylene‐calcium carbonate based piezoelectric films were obtained using biaxial stretching and gas‐mediated inflation followed by a corona discharge treatment using home‐made devices. The obtained results revealed a cellular structure that develops at the interface between the solid particles and the polymer matrix and the final piezoelectric coefficient was found to depend both on the gas pressure profile and on time. The inflation step gives better results when the gas pressure is increased in stepwise manner allowing the gas to adequately intrude the cavities and maintain the required pressure. The overall results are discussed in terms of processing conditions and in terms of the developed microstructure. POLYM. ENG. SCI., 2012. © 2012 Society of Plastics Engineers 相似文献
10.
Azim Ziyaei Halimehjani M. Ali Alaei Farzaneh Soleymani Movahed Negin Jomeh Mohammad R. Saidi 《Journal of Sulfur Chemistry》2016,37(5):529-536
An effective approach for the synthesis of 2-(alkylthio)thiazol-4(5H)-ones from alkyl dithiocarbamates and chloroacetyl chloride in the presence of NaHCO3 has been developed. Good to excellent yields of products, simple reaction conditions and general applicability are the most important advantages of this protocol. 相似文献