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1.
The increasing prevalence of streptococci as causes of potentially fatal nosocomial bacteremia requires that antimicrobial agents used for empiric therapy in hospitalized patients include both pneumococci and viridans group streptococci as well as beta-hemolytic streptococci in their activity profile. In this study, the in vitro activity of cefepime, a new fourth-generation cephalosporin, was compared with other cephalosporins versus 197 nosocomial blood stream isolates of streptococci (20 Streptococcus pneumoniae, 104 viridans group, and 73 beta-hemolytic) isolated from patients at more than 30 medial centers from 1995 to 1997. Additional agents tested included penicillin, erythromycin, and vancomycin. Overall, cefepime inhibited 83% of the isolates at concentrations < or = 0.5 microgram/mL and 100% at < or = 8 micrograms/mL. By comparison, ceftazidime inhibited 35 and 88% of isolates at the same concentrations. Cefepime was approximately eightfold more potent than ceftazidime against S. pneumoniae, viridans group streptococci, and beta-hemolytic streptococci. Among the 42 isolates with penicillin MICs > 0.12 microgram/mL, 100% were inhibited by cefepime and only 48% by ceftazidime at < or = 8 micrograms/mL. The rank order of activity for all six agents against the 197 isolates was vancomycin > ceftriaxone > cefepime > penicillin > erythromycin > ceftazidime. Based on the results of the present study, cefepime and ceftriaxone were the superior cephalosporins in potency and spectrum for empiric coverage of patients at risk for streptococcal blood stream infections.  相似文献   
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Numerical Modeling of Cemented Mine Backfill Deposition   总被引:1,自引:0,他引:1  
In current underground mining practice, it is common to use tailings, without added cement, to fill mined-out voids (“stopes”). If fine-grained tailings are used, the high placement rates and low permeability can often result in undrained loading conditions and, hence, lower effective stress, when assessed in the conventional manner. Where cement is added, the cement modifies the consolidation characteristics in a number of ways, including increasing the strength and stiffness, reducing the permeability, and inducing volumetric changes associated with the hydration reactions leading to “self-desiccation.” As a result, conventional consolidation-analysis techniques are unsuitable for assessing the behavior. The one-dimensional mine-tailings-consolidation program (MinTaCo) has been modified, and renamed CeMinTaCo, to couple cement hydration with conventional consolidation analysis. The fundamental theory behind the modifications is presented. The model is used to undertake a sensitivity study, which highlights some of the important features of the behavior of cemented backfill, and shows how complex interactions between the various properties produce some outcomes that are counterintuitive.  相似文献   
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The lack of uniformity of analytical techniques employed for quantification of fatty acids led to the successful implementation of a rapid transesterification method using tetramethylammonium hydroxide to determine and compare the total fatty acid content of almond, pecan and macadamia oils. Palmitic, oleic and linoleic acids comprised the largest part of the total fatty acid content in almond and pecan oils. Although oleic acid was also the main constituent of macadamia oil, its concentration was substantially lower than in the other oils.  相似文献   
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Electrokinetic geosynthetics (EKGs) were developed about a decade ago, producing a material that did not experience the same corrosion problems as metal electrodes when used in electro-osmotic (EO) dewatering applications. The conductive polymeric material from which EKGs are made has the additional advantage of being able to be formed into a variety of shapes, including drainage tubes such as those used in this study. One of the primary concerns regarding EO dewatering applications is the rate of energy consumption. This paper reports experiments at three different scales, on different mine tailings materials, that illustrates the potentially misleading results obtained from small scale laboratory tests. Using large, outdoor tests, power consumption rates for treating a kaolinitic mineral sands tailings and a smectitic diamond tailings were found to be up to 30 times lower than the power consumption rates obtained from laboratory tests using small samples in a purpose built EO cell. The primary reason for the improved performance is thought to be the lower voltage gradient used in the field tests, plus the geometric advantages offered by a field layout where a greater volume of material is exposed to the EO effect than only the material directly between the electrodes, which is the case in the EO cell tests. Finally, in the field tests the EO treatment caused the early development of vertical cracks in the tailings, resulting in increased exposure of the tailings to the effects of solar drying. This effect cannot obviously be reproduced in the EO cell laboratory tests, and can be a major advantage for the in situ treatment of mine tailings lagoons, where in some materials the onset of cracking is significantly delayed by the development of an impermeable surface crust.  相似文献   
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J. T. Fourie 《Scanning》1989,11(6):281-291
It is proposed that when a thin sample is mounted on the top surface of a thick single crystal foil, this foil may function as a collector aperture with regard to the radiation transmitted through the thin sample. The detailed aspects of how the crystal foil may perform as an aperture are discussed in terms of the electron equivalent of the Borrmann effect in crystals. Experiments are presented which demonstrate that the image of the thin sample is sensitive to the thickness of the single crystal foil and to its orientation with regard to the beam axis. It is concluded from the experimental results that the crystal foil does perform a collector aperture-like function.  相似文献   
8.
Blends of polyethylene and poly(vinyl chloride) were prepared on a Brabender Plasticorder, and attempts were made to improve the very inferior physical properties of the product. The blends were found to have domain structures, and it was shown that their physical properties could be improved very considerably if the domain sizes could be reduced drastically. However, in melt blending, there was a limit to the reduction of domain sizes. A noticeable improvement in properties was achieved through the use of various fillers and crosslinking agents. Small changes in crystallite size and percentage crystallinity were observed where certain additives were used. It appeared that the additives that were most effective in enhancing physical properties acted by improving load transfer at the interface between the two polymer phases.  相似文献   
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The purpose of this paper is to report on the convergence rates of two iterative matrix solution methods individually and then to combine the two methods into a hybrid scheme to achieve additional convergence rate benefits. One iterative matrix solver investigated is the sparse iterative method (SIM) which is a stationary, Jacobi-like solver but uses a sparse and not a banded matrix, with matrix elements corresponding to strong interactions, rather than position in the matrix. In this paper, the SIM is modified to include an adaptive relaxation scheme to improve its convergence speed and numerical stability. Another iterative scheme investigated is the nonstationary biconjugate gradient stabilized (BiCGSTAB) method. It is shown that the BiCGSTAB is considerably improved when the method is preconditioned by the sparse matrix used in the SIM method. Finally, a hybrid scheme is proposed which combines both SIM-AR and BiCGSTAB-precon and it is shown that the hybrid gives best results on the problems considered. Examples giving convergence time versus accuracy are presented for two problems: a wire-grid plate, and a wire-grid partial helicopter  相似文献   
10.
We describe a three-generation family with an autosomal dominant hidrotic ectodermal dysplasia consisting mainly of tricho- and onychodysplasia. One of the patients had supraventricular tachycardia, another had palpitations, and two others had sinus brachycardia. We consider that the clinical manifestations in this family differ significantly from those of the Clouston syndrome (their previous diagnosis) and places them in Group A, subgroup 1-3 (tricho-onychic) of the ectodermal dysplasia classification proposed by Freire-Maia and Pinheiro [1988, "Ectodermal Dysplasias"].  相似文献   
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