全文获取类型
收费全文 | 2432篇 |
免费 | 164篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 11篇 |
综合类 | 1篇 |
化学工业 | 837篇 |
金属工艺 | 32篇 |
机械仪表 | 38篇 |
建筑科学 | 90篇 |
矿业工程 | 7篇 |
能源动力 | 55篇 |
轻工业 | 485篇 |
水利工程 | 22篇 |
石油天然气 | 8篇 |
无线电 | 132篇 |
一般工业技术 | 345篇 |
冶金工业 | 248篇 |
原子能技术 | 13篇 |
自动化技术 | 273篇 |
出版年
2023年 | 30篇 |
2022年 | 169篇 |
2021年 | 253篇 |
2020年 | 95篇 |
2019年 | 80篇 |
2018年 | 86篇 |
2017年 | 75篇 |
2016年 | 93篇 |
2015年 | 79篇 |
2014年 | 104篇 |
2013年 | 168篇 |
2012年 | 135篇 |
2011年 | 169篇 |
2010年 | 134篇 |
2009年 | 105篇 |
2008年 | 113篇 |
2007年 | 94篇 |
2006年 | 87篇 |
2005年 | 74篇 |
2004年 | 59篇 |
2003年 | 42篇 |
2002年 | 42篇 |
2001年 | 21篇 |
2000年 | 18篇 |
1999年 | 19篇 |
1998年 | 20篇 |
1997年 | 23篇 |
1996年 | 22篇 |
1995年 | 16篇 |
1994年 | 8篇 |
1993年 | 9篇 |
1992年 | 5篇 |
1990年 | 9篇 |
1989年 | 13篇 |
1988年 | 11篇 |
1987年 | 12篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1972年 | 8篇 |
排序方式: 共有2597条查询结果,搜索用时 15 毫秒
1.
Virginia Veronica Visconti Ida Cariati Simona Fittipaldi Riccardo Iundusi Elena Gasbarra Umberto Tarantino Annalisa Botta 《International journal of molecular sciences》2021,22(8)
DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions. 相似文献
2.
Alison Willette Benjamin Fallen Hem Bhandari Carl Sams Feng Chen Virginia Sykes Chris Smallwood Kristin Bilyeu Zenglu Li Vincent Pantalone 《Journal of the American Oil Chemists' Society》2021,98(8):861-869
Soybean oil hydrogenation alters the linolenic acid molecule to prevent the oil from becoming rancid, however, health reports have indicated trans-fat caused by hydrogenation, is not generally regarded as safe. Typical soybeans contain approximately 80 g kg−1 to 120 g kg−1 linolenic acid and 240 g kg−1 of oleic acid. In an effort to accommodate the need for high-quality oil, the United Soybean Board introduced an industry standard for a high oleic acid greater than 750 g kg−1 and linolenic acid less than 30 g kg−1 oil. By combing mutations in the soybean plant at four loci, FAD2-1A and FAD2-1B, oleate desaturase genes and FAD3A and FAD3C, linoleate desaturase genes, and seed oil will not require hydrogenation to prevent oxidation and produce high-quality oil. In 2017 and 2018, a study comparing four near-isogenic lines across multiple Tennessee locations was performed to identify agronomic traits associated with mutations in FAD3A and FAD3C loci, while holding FAD2-1A and FAD2-1B constant in the mutant (high oleic) state. Soybean lines were assessed for yield and oil quality based on mutations at FAD2-1 and FAD3 loci. Variations of wild-type and mutant genotypes were compared at FAD3A and FAD3C loci. Analysis using a generalized linear mixed model in SAS 9.4, indicated no yield drag or other negative agronomic traits associated with the high oleic and low linolenic acid genotype. All four mutations of fad2-1A, fad2-1B, fad3A, and fad3C were determined as necessary to produce a soybean with the new industry standard (>750 g kg−1 oleic and <30 g kg−1 linolenic acid) in a maturity group-IV-Late cultivar for Tennessee growers. 相似文献
3.
Bianka Rocha Saraiva Lucas Henrique Maldonado da Silva Fernando Antônio Anjo Ana Carolina Pelaes Vital Jéssica Bassi Da Silva Marcos Luciano Bruschi Paula Toshimi Matumoto Pintro 《International Journal of Food Science & Technology》2020,55(5):1962-1970
Debittered trub (brewing waste) is an important source of protein source (70.26%). Trub and whey protein were used for 5% protein enrichment of ice cream frozen by liquid nitrogen. Three formulations were elaborated: ice cream standard (ICS), ice cream with whey protein (ICW) and ice cream with trub (ICT). Chemical composition, rheological properties, texture, overrun, melting rate, scanning electron microscopy and a sensorial test were performed. Results showed that ICT presented a higher viscosity, obtained on the upward curve up to 6.76 Pa s−1, consistency index (22.96 (Pa s−1)n), hysteresis area (140.40 mPa s−1) and hardness (31113.33 g) but a lower melting rate (0.38 g min−1), overrun (13.92%) and sensorial acceptability than the other formulations. The addition of trub debittered for protein enrichment improved ice cream properties and demonstrated that it could be used as a food ingredient. 相似文献
4.
5.
Simone Grassi Oscar Campuzano Mnica Coll Francesca Cazzato Georgia Sarquella-Brugada Riccardo Rossi Vincenzo Arena Josep Brugada Ramon Brugada Antonio Oliva 《International journal of molecular sciences》2021,22(8)
Inherited cardiomyopathies are frequent causes of sudden cardiac death (SCD), especially in young patients. Despite at the autopsy they usually have distinctive microscopic and/or macroscopic diagnostic features, their phenotypes may be mild or ambiguous, possibly leading to misdiagnoses or missed diagnoses. In this review, the main differential diagnoses of hypertrophic cardiomyopathy (e.g., athlete’s heart, idiopathic left ventricular hypertrophy), arrhythmogenic cardiomyopathy (e.g., adipositas cordis, myocarditis) and dilated cardiomyopathy (e.g., acquired forms of dilated cardiomyopathy, left ventricular noncompaction) are discussed. Moreover, the diagnostic issues in SCD victims affected by phenotype-negative hypertrophic cardiomyopathy and the relationship between myocardial bridging and hypertrophic cardiomyopathy are analyzed. Finally, the applications/limits of virtopsy and post-mortem genetic testing in this field are discussed, with particular attention to the issues related to the assessment of the significance of the genetic variants. 相似文献
6.
Adele Boccuto Filippo Dragoni Francesca Picarazzi Alessia Lai Carla Della Ventura Carla Veo Federica Giammarino Francesco Saladini Gianguglielmo Zehender Maurizio Zazzi Mattia Mori Ilaria Vicenti 《International journal of molecular sciences》2021,22(5)
The nucleotide analog sofosbuvir, licensed for the treatment of hepatitis C, recently revealed activity against the Zika virus (ZIKV) in vitro and in animal models. However, the ZIKV genetic barrier to sofosbuvir has not yet been characterized. In this study, in vitro selection experiments were performed in infected human hepatoma cell lines. Increasing drug pressure significantly delayed viral breakthrough (p = 0.029). A double mutant in the NS5 gene (V360L/V607I) emerged in 3 independent experiments at 40–80 µM sofosbuvir resulting in a 3.9 ± 0.9-fold half- maximal inhibitory concentration (IC50) shift with respect to the wild type (WT) virus. A triple mutant (C269Y/V360L/V607I), detected in one experiment at 80 µM, conferred a 6.8-fold IC50 shift with respect to the WT. Molecular dynamics simulations confirmed that the double mutant V360L/V607I impacts the binding mode of sofosbuvir, supporting its role in sofosbuvir resistance. Due to the distance from the catalytic site and to the lack of reliable structural data, the contribution of C269Y was not investigated in silico. By a combination of sequence analysis, phenotypic susceptibility testing, and molecular modeling, we characterized a double ZIKV NS5 mutant with decreased sofosbuvir susceptibility. These data add important information to the profile of sofosbuvir as a possible lead for anti-ZIKV drug development. 相似文献
7.
Joe Virginia 《电子产品世界》2006,(4):67-68
今天的液晶显示器(LCD)所达到的性能和图像质量在仅仅几年之前还是梦想,LCD显示器在几个相关的前沿领域不断发展.小型LCD体现得比其他任何领域都更为真切.手机行业的激烈竞争和螺旋式上升的用户需求正在驱动显示技术去满足融合的需要,即移动通信与移动计算和/或移动娱乐的融合. 相似文献
8.
Serum total cholesterol, high density lipoprotein (HDL) cholesterol, and triglyceride levels were studied in healthy male
and female subjects consuming for one-week periods a diet of conventional food (CF) providing 42% of energy as fat, principally
butter fat, and then in random order nutritionally complete, defined formula diets of moderate (32%) to very low (1%) fat
content. Compared to CF, the formula with 32% of energy as corn oil lowered serum cholesterol by 25% and the ratio of total
to HDL-cholesterol by 13%. Low (9%) and very low (1–3%) fat formulas reduced HDL-cholesterol by as much as 40%, raised the
total: HDL-cholesterol ratio by about 20% and raised serum triglyceride levels by as much as 100%. When low and very low fat
formulas were ingested for three weeks, these effects persisted although maximal responses occurred during the first week.
These results demonstrated that a moderate fat formula diet with a high P/S ratio had a more favorable effect on serum lipid
levels than various low fat formulas. Low fat conventional food diets should be studied in long-term controlled metabolic
experiments before such diets are recommended to the general population for coronary heart disease or cancer prevention. 相似文献
9.
Ryba Nancy L.; Cooper Virginia G.; Zapf Patricia A. 《Canadian Metallurgical Quarterly》2003,34(5):499
What is the current standard of practice for evaluations of juvenile competence to stand trial (JCST)? The present study surveyed psychologists regarding the practices used when conducting JCST evaluations. Respondents rated the importance of 17 elements that might be included in a JCST evaluation report. Of these elements, 7 were considered essential by 70% or more of respondents, with 9 additional elements rated as either essential or recommended. A majority of respondents felt that the use of psychological and forensic instruments was important. A list of tests used is provided, and the implications for the development of standards and policy are discussed to provide practitioners with additional knowledge that will help to further the state of the discipline. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.