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排序方式: 共有452条查询结果,搜索用时 15 毫秒
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Valentina I. Simagina Pavel A. Storozhenko Olga V. Netskina Oksana V. Komova Galina V. Odegova Yury V. Larichev Arcady V. Ishchenko Anna M. Ozerova 《Catalysis Today》2008,138(3-4):253
Catalytic hydrolysis of NaBH4 and NH3BH3 has been studied. It was shown that the nature of the support and the active component of the catalyst affect the H2 generation rate. Despite similar sizes of rhodium particles formed on the surface of different supports (γ-Al2O3, TiO2, carbon), their reactivity is different. Rh/TiO2 with low rhodium concentration (1 wt.%) is the most active catalyst both in the hydrolysis of NaBH4 and NH3BH3. The obtained results show that the rhodium chloride interaction with titania determines the reactivity of rhodium particles formed under action of NaBH4 medium. TEM, DRS UV–vis and XPS were used to characterize the catalysts. 相似文献
3.
Tkachenko Yurii G. Britun Yurchenko Djema Z. Ochkas Larisa F. Bovkun Galina A. 《Powder Metallurgy and Metal Ceramics》2004,43(1-2):99-104
The influence which the composition of powder mixtures, the treatment conditions which the mixtures are subjected to, and the conditions under which the hot-pressed composite materials B4C – (5-10 mass%) calcium-silicon are fabricated exert on the structure, nature of failure, and mechanical properties of these materials is investigated. Optimum properties are possessed by material containing 10 mass% of addition. It is shown that the structure, morphology, and dispersivity, as well as the nature of the distribution of the components that are added to the composite material (secondary phase) vary as the temperature of hot pressing changes. Maximal mechanical characteristics of the composite material (σbend = 560 MPa, K 1c = 4.7 MPa·m1/2, HV = 37 GPa) are attained at hot-pressing temperatures in the range 2000-2100°C. 相似文献
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Galina M. Viryasova Ekaterina A. Golenkina Tibor Hianik Nataliya V. Soshnikova Nina G. Dolinnaya Tatjana V. Gaponova Yulia M. Romanova Galina F. Sudina 《International journal of molecular sciences》2021,22(5)
Neutrophil-mediated innate host defense mechanisms include pathogen elimination through bacterial phagocytosis, which activates the 5-lipoxygenase (5-LOX) product synthesis. Here, we studied the effect of synthetic oligodeoxyribonucleotides (ODNs), which mimic the receptor-recognized sites of bacterial (CpG-ODNs) and genomic (G-rich ODNs) DNAs released from the inflammatory area, on the neutrophil functions after cell stimulation with Salmonella typhimurium. A possible mechanism for ODN recognition by Toll-like receptor 9 (TLR9) and RAGE receptor has been proposed. We found for the first time that the combination of the magic peptide LRR11 from the leucine-rich repeat (LRR) of TLR9 with the CpG-ODNs modulates the uptake and signaling from ODNs, in particular, dramatically stimulates 5-LOX pathway. Using thickness shear mode acoustic method, we confirmed the specific binding of CpG-ODNs, but not G-rich ODN, to LRR11. The RAGE receptor has been shown to play an important role in promoting ODN uptake. Thus, FPS-ZM1, a high-affinity RAGE inhibitor, suppresses the synthesis of 5-LOX products and reduces the uptake of ODNs by neutrophils; the inhibitor effect being abolished by the addition of LRR11. The results obtained revealed that the studied peptide-ODN complexes possess high biological activity and can be promising for the development of effective vaccine adjuvants and antimicrobial therapeutics. 相似文献
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Olga Shilova Elena Shramova Galina Proshkina Sergey Deyev 《International journal of molecular sciences》2021,22(9)
Cancer cells frequently overexpress specific surface receptors providing tumor growth and survival which can be used for precise therapy. Targeting cancer cell receptors with protein toxins is an attractive approach widely used in contemporary experimental oncology and preclinical studies. Methods of targeted delivery of toxins to cancer cells, different drug carriers based on nanosized materials (liposomes, nanoparticles, polymers), the most promising designed light-activated toxins, as well as mechanisms of the cytotoxic action of the main natural toxins used in modern experimental oncology, are discussed in this review. The prospects of the combined therapy of tumors based on multimodal nanostructures are also discussed. 相似文献
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A new method of preparation of carboxyl cation exchangers directly from methacrylic acid and divinylbenzene is described. A suspension technique with a concentrated aqueous calcium chloride solution as the water phase was used. n-Octane and toluene were inert diluents of the monomers. The copolymers obtained have high ion-exchange capacity (9.6–10.6 mequ./g) and porous structure. 相似文献
9.
Yurii G. Tkachenko Viktor F. Britun Emmanuil V. Prilutskii Dzhemma Z. Yurchenko Galina A. Bovkun 《Powder Metallurgy and Metal Ceramics》2005,44(3-4):196-201
We have investigated how the composition, grain morphology, and method of preparing the starting mixture affect the processes that form the structure and phase composition of B4C - SiC composites during hot pressing. We found that, depending on the composition of the initial powder mixtures, which is responsible for different mechanisms of consolidation of ceramic materials during hot pressing, the grain size of the main B4C phase and its defect content as well as the nature of the SiC phase distribution within the material differ significantly. When B4C - SiC composites with a low SiC content are made from initial B4C - B4Si - B - C powder mixtures those composites have a high cracking resistance because of their fine grain structure.__________Translated from Poroshkovaya Metallurgiya, Nos. 3–4(442), pp. 112–119, March–April, 2005. 相似文献
10.
Mikhail G. Akimov Alina M. Gamisonia Polina V. Dudina Natalia M. Gretskaya Anastasia A. Gaydaryova Andrey S. Kuznetsov Galina N. Zinchenko Vladimir V. Bezuglov 《International journal of molecular sciences》2021,22(2)
GPR55 is a GPCR of the non-CB1/CB2 cannabinoid receptor family, which is activated by lysophosphatidylinositol (LPI) and stimulates the proliferation of cancer cells. Anandamide, a bioactive lipid endocannabinoid, acts as a biased agonist of GPR55 and induces cancer cell death, but is unstable and psychoactive. We hypothesized that other endocannabinoids and structurally similar compounds, which are more hydrolytically stable, could also induce cancer cell death via GPR55 activation. We chemically synthesized and tested a set of fatty acid amides and esters for cell death induction via GPR55 activation. The most active compounds appeared to be N-acyl dopamines, especially N-docosahexaenoyl dopamine (DHA-DA). Using a panel of cancer cell lines and a set of receptor and intracellular signal transduction machinery inhibitors together with cell viability, Ca2+, NO, ROS (reactive oxygen species) and gene expression measurement, we showed for the first time that for these compounds, the mechanism of cell death induction differed from that published for anandamide and included neuronal nitric oxide synthase (nNOS) overstimulation with concomitant oxidative stress induction. The combination of DHA-DA with LPI, which normally stimulates cancer proliferation and is increased in cancer setting, had an increased cytotoxicity for the cancer cells indicating a therapeutic potential. 相似文献