Industry 4.0: a supply chain innovation perspective

The Fourth Industrial Revolution – also known as Industry 4.0 (i4.0) – comprises the digitalisation of the industrial sector. This paper uses the theoretical lens of supply chain innovation (SCI) to investigate the implications of i4.0 on supply chain management. For these purposes, the method of structured content analysis is applied to more than 200 use cases of i4.0-enabled SCI introduced by both established and startup companies. i4.0-enabled SCI manifests along three dimensions: process, technology, and business architecture. The key findings of this study can be summarised as follows: first, i4.0-enabled SCI extends the initial focus on productivity improvements in SC processes towards scalability and flexibility. Second, extant i4.0 solutions rely mostly on analytics and smart things while omitting smart people technology and the human-centric approach associated with the i4.0 paradigm. Third, established companies adopt i4.0 merely to sustain their existing business architectures while startup companies radically change their operating models, relying heavily on data analytics and the platform economy. Consequently, established companies pursue a problem-driven, engineering-based approach to SCI while startup companies follow an ‘asset-light’, business-driven approach. Lastly, there are two distinct approaches to digitalising operational SC processes: platform-based crowdsourcing of standard processes and on-demand provision of customised services.     

Magnetic Resonance Signal Amplification by Reversible Exchange of Selective PyFALGEA Oligopeptide Ligands Towards Epidermal Growth Factor Receptors

The biorelevant PyFALGEA oligopeptide ligand, which is selective towards the epidermal growth factor receptor (EGFR), has been successfully employed as a substrate in magnetic resonance signal amplification by reversible exchange (SABRE) experiments. It is demonstrated that PyFALGEA and the iridium catalyst IMes form a PyFALGEA:IMes molecular complex. The interaction between PyFALGEA:IMes and H₂ results in a ternary SABRE complex. Selective 1D EXSY experiments reveal that this complex is labile, which is an essential condition for successful hyperpolarization by SABRE. Polarization transfer from parahydrogen to PyFALGEA is observed leading to significant enhancement of the ¹H NMR signals of PyFALGEA. Different iridium catalysts and peptides are inspected to discuss the influence of their molecular structures on the efficiency of hyperpolarization. It is observed that PyFALGEA oligopeptide hyperpolarization is more efficient when an iridium catalyst with a sterically less demanding NHC ligand system such as IMesBn is employed. Experiments with shorter analogues of PyFALGEA, that is, PyLGEA and PyEA, show that the bulky phenylalanine from the PyFALGEA oligopeptide causes steric hindrance in the SABRE complex, which hampers hyperpolarization with IMes. Finally, a single-scan ¹H NMR SABRE experiment of PyFALGEA with IMesBn revealed a unique pattern of NMR lines in the hydride region, which can be treated as a fingerprint of this important oligopeptide.     

Semantic Web Mining: State of the art and future directions

Semantic Web Mining aims at combining the two fast-developing research areas Semantic Web and Web Mining. This survey analyzes the convergence of trends from both areas: More and more researchers are working on improving the results of Web Mining by exploiting semantic structures in the Web, and they make use of Web Mining techniques for building the Semantic Web. Last but not least, these techniques can be used for mining the Semantic Web itself.The Semantic Web is the second-generation WWW, enriched by machine-processable information which supports the user in his tasks. Given the enormous size even of today’s Web, it is impossible to manually enrich all of these resources. Therefore, automated schemes for learning the relevant information are increasingly being used. Web Mining aims at discovering insights about the meaning of Web resources and their usage. Given the primarily syntactical nature of the data being mined, the discovery of meaning is impossible based on these data only. Therefore, formalizations of the semantics of Web sites and navigation behavior are becoming more and more common. Furthermore, mining the Semantic Web itself is another upcoming application. We argue that the two areas Web Mining and Semantic Web need each other to fulfill their goals, but that the full potential of this convergence is not yet realized. This paper gives an overview of where the two areas meet today, and sketches ways of how a closer integration could be profitable.     

Finite element analysis of loaded structures at very high temperatures

At very high temperatures loaded metallic structures undergo creep deformations. The generated creep strains are connected with stress relaxations, stress redistributions and/or progressive deformations.In mainly load controlled situations the behaviour of the material can be described by a nonlinear viscous flow law (Norton power law).A stress-deformation analysis of complex structures can be carried out by finite element codes in which the mentioned constitutive equation is implemented. The code PERMAS-VISCOUS was used to analyse the stress state of a notched tension bar and the deformation behaviour of a tube under external pressure undergoing a creep collapse. The relation to experimental findings is also given.     

Geolocation and pointing accuracy analysis for the WindSat sensor

Geolocation and pointing accuracy analyses of the WindSat flight data are presented. The two topics were intertwined in the flight data analysis and will be addressed together. WindSat has no unusual geolocation requirements relative to other sensors, but its beam pointing knowledge accuracy is especially critical to support accurate polarimetric radiometry. Pointing accuracy was improved and verified using geolocation analysis in conjunction with scan bias analysis. Two methods were needed to properly identify and differentiate between data time tagging and pointing knowledge errors. Matchups comparing coastlines indicated in imagery data with their known geographic locations were used to identify geolocation errors. These coastline matchups showed possible pointing errors with ambiguities as to the true source of the errors. Scan bias analysis of U, the third Stokes parameter, and of vertical and horizontal polarizations provided measurement of pointing offsets resolving ambiguities in the coastline matchup analysis. Several geolocation and pointing bias sources were incrementally eliminated resulting in pointing knowledge and geolocation accuracy that met all design requirements.     

Mechanism of Oxide Nucleation in Lithium Aluminosilicate Glass-Ceramics

A commercial lithium aluminosilicate glass-ceramic material is investigated by high-resolution transmission electron microscopy after different heat treatments. Evidence is presented that epitaxy of β-quartz crystals on ZrTiO₄-type crystallites is the critical step initiating silicate crystallization.