Pyran derivatives. XX. 2-Aminochromone benzo-fused derivatives with antiproliferative properties

The N-substituted 2-aminochromones 1 and their benzo-fused derivatives 2-4 described herein were mostly prepared by treating the corresponding (methylthio) derivatives 10-13 with an excess of the proper amines. Only the morpholino derivatives 3d and 4c were obtained from the reaction of the ethyl 3-morpholino-3-oxopropanoate/POCl3 reagent with 1-naphthol or 1-methyl-2-naphthol, respectively. The amino derivatives 1-4, as well as their methylthio analogues 10-13, were tested in vitro for their inhibitory activity on the infectivity of T2 bacteriophage, on the macromolecular synthesis in Ehrlich cells and on the clonal growth capacity of HeLa cells. Several of the angular or linear aminonaphthopyranones 2 and 3 or 4, respectively, and the (methylthio) derivatives 10, 11 and 13 induced a significant inhibition of DNA synthesis, but usually a clearly lower inhibition of clonal growth. Only the linear 2-amino-10-methyl-4H-naphtho[2,3-b]pyran-4-ones 4a and 4b significantly inhibited the clonal growth in HeLa cells and T2 bacteriophage infectivity, respectively.     

隔板式内循环气化炉的设计和运行

介绍了一种新型的隔板式内循环气化炉的设计和运行。通过在气化炉的中间设置隔板,可使流化床气化炉的床层形成2个流化速度不等的流化区域,在高速区没有反应的原料或炭粒,在床层上部随流化介质流入低速区,在低速区内进行气化反应;未反应完的炭粒再经底部流回高速区,进一步进行气化反应,形成一个内部循环,从而达到延长原料在炉内的反应时间、增强气化效率的效果。实验结果表明:这种气化炉反应温度在790—850℃时,气化效果最好,产气率为1.6—1.9m3/kg,气体热值为5340kJ/m3(木质类原料)或4880kJ/m3(稻壳),气化效率可达70%。