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1.
An inventory control system has been developed for a distribution system consisting of a single multiproduct warehouse serving a set of customers and purchasing products from multiple vendors. Purchase orders requesting multiple products are delivered to the warehouse in a process referred to as joint replenishment. The receipt of customer orders by the warehouse proceeds in order intervals and in order quantities that are subject to random fluctuations. The objective of warehouse operation is to minimize the total cost while maintaining inventory levels within the warehouse capacity by adjusting the purchase order intervals and quantities. An adaptive model predictive control algorithm is developed using a periodic square wave model to represent the material flows. The adaptive concept incorporates a stabilized minimum variance control-type input calculation coupled with input/output stream parameter predictions. The boundedness of the control output under the suggested algorithm is mathematically proven under the assumption that disturbances in the orders are bounded. The effectiveness of the scheme was demonstrated using simulations. 相似文献
2.
An inventory control system was developed for multiproduct batch plants with an arbitrary number of batch processes and storage units. Customer orders are received by the plant at order intervals and in order quantities that are subject to random fluctuations. The objective of the plant operation is to minimize the total cost while maintaining inventory levels within the storage or warehouse capacity by adjusting the startup times, the quantities of raw material orders, and production batch sizes. An adaptive model predictive control algorithm was developed that uses a periodic square wave model to represent the flows of the material between the processes and the storage units. The boundedness of the control output and the convergence of the estimated parameters in implementations of the proposed algorithm were mathematically proven under the assumption that disturbances in the orders are bounded. The effectiveness of this approach was demonstrated by performing simulations. © 2015 American Institute of Chemical Engineers AIChE J, 61: 1867–1880, 2015 相似文献
3.
Valincius G Ignatjev I Niaura G Kazemekaite M Talaikyte Z Razumas V Svendsen A 《Analytical chemistry》2005,77(8):2632-2636
A novel electrochemical technique for the general assay of lipase activity is described. The method utilizes a solid-supported lipase substrate, which is formed by dripping and drying a small amount of an ethanol solution of 9-(5'-ferrocenylpentanoyloxy)nonyl disulfide (FPONDS) onto gold modified by a hexanethiol self-assembled monolayer. The redox ferrocene group of FPONDS generates the electrochemical signal, the intensity of which is proportional to the number of FPONDS molecules at the interface. Electrochemical and surface-enhanced infrared absorption spectroscopic data, as well as control experiments with an engineered, deactivated mutant enzyme, demonstrate that the wild-type lipase from Thermomyces lanuginosus is capable of cleaving the ester bonds of FPONDS molecules via an enzymatic hydrolysis mechanism, which includes the adsorption of the lipase onto the substrate surface. The hydrolysis liberates the ferrocene groups from the interface triggering a decay of the electrochemical redox signal. The rate of the electrochemical signal decrease is proportional to the lipase activity/concentration. These data suggest a general method for the direct measure of enzymatic activity of lipases. 相似文献
4.
The electroreduction kinetics of silver sulfite complexes was investigated by rotation disk electrode (RDE) voltammetry, chronopotentiometry (CP) and electrochemical impedance spectroscopy (EIS). The stability constants of the silver sulfite complexes, pβ2 = 7.9 and pβ3 = 8.53 were determined. For the series of isopotential solutions investigated, a reaction order of 0.67 was obtained, the diffusion coefficient of the silver complexes varies in the range of 3.36 × 10−6 to 5.54 × 10−6 cm2 s−1 and the silver degree of complexation (2.31-2.67) were found. The analysis of the RDE, CP data and EIS spectra indicate the existence of a slow stage of the silver electrocrystallization in the region of the equilibrium potential and at stronger polarization of the electrode at initial time moments. 相似文献
5.
Linas Minkevičius Vincas Tamošiūnas Martynas Kojelis Ernestas Žąsinas Virginijus Bukauskas Arūnas Šetkus Renata Butkutė Irmantas Kašalynas Gintaras Valušis 《Journal of Infrared, Millimeter and Terahertz Waves》2017,38(6):689-707
A detailed electrical characterization of high-performance bow-tie InGaAs-based terahertz detectors is presented along with simulation results. The local surface potential and tunnelling current were scanned over the surfaces of the detectors by means of Kelvin probe force microscopy (KPFM) and scanning tunnelling microscopy (STM), which also enabled the determination of the Fermi level. Current-voltage curves were measured and modelled using the Synopsys Sentaurus TCAD package to gain deeper insight into the processes involved in detector operation. In addition, we performed finite-difference time-domain (FDTD) simulations to reveal features related to changes in the electric field due to the metal detector contacts. The investigation revealed that field-effect-induced conductivity modulation is a possible mechanism contributing to the high sensitivity of the studied detectors. 相似文献
6.
Gintaras Baltrūnas Aušra Valiūnienė Justas Vienožinskis Ernestas Gaidamauskas Teofilis Jankauskas Žana Margarian 《Journal of Applied Electrochemistry》2008,38(11):1519-1526
Electrochemical gold deposition from sulfite solutions was studied by means of voltammetry, EIS and EQCM. A gold film electrode
was used for polyaniline layer formation by electrochemical oxidation of aniline. The standard electrochemical reduction potential
of the reaction [Au(SO3)2]3− + e− = Au + 2 SO32− was determined, and is equal to 0.116 V (vs. NHE). Both solution stirring and temperature increase accelerate the electrochemical
reduction of gold, when the electrode potential is below −0.55 V. When the potential is above −0.55 V the electrochemical
reduction proceeds via passive layer formation. Our study suggests that the passive layer consists of chemically adsorbed
sulfite ions and sulfur. The gold film deposited from sulfite solution is a high quality substrate suitable for conducting
polymer layer formation. This technique, where a polymer layer electrode is prepared by thin gold film deposition onto a metal
surface and by subsequent polymer layer formation, can be applied in sensor research and technology. 相似文献
7.
José M. Laínez‐Aguirre Gintaras V. Reklaitis 《American Institute of Chemical Engineers》2013,59(9):3296-3307
Quantitative methods for individualizing and optimizing the dosage regimen and clinically monitoring each patient are desirable to insure that each patient can obtain effective therapeutic benefit while minimizing undesirable side effects. This is of special concern for medicines that are expensive or whose toxic side effects are severe (e.g., oncological agents). The optimal dosage regimen for an individual is a combination of dose amount and/or dosing interval (i.e., time between doses) which minimizes the risk that the drug exposure deviates from the desired therapeutic window. The therapeutic window is defined as the range of drug exposure (e.g., blood concentration, area under the curve concentration‐time) which is below a threshold defining an acceptable toxic side effect and above a threshold defining a minimum acceptable level of therapeutic efficacy. In this work, the dosage regimen optimization problem defined in terms of general pharmacometric models (i.e., described by differential‐algebraic equations) is presented and a solution approach outlined which uses a scenario‐based stochastic optimization formulation that minimizes a risk metric. The scenarios are derived from the posterior joint probability distribution of the individual's pharmacometric parameters which is obtained following an approximate Bayesian inference approach. A Smolyak rule is used for the selection of the scenarios (i.e., combination of pharmacometric parameters) to be considered and for computing the approximation to the risk metric. Two case studies, gabapentin and cyclophosphamide, are presented to elucidate the advantages and limitations of the proposed approach. The numerical results demonstrate that low risk optimal solutions can be generated via the proposed stochastic optimization; while significantly reducing the computational burden in comparison with the conventional Markov chain Monte Carlo—grid search approach. This partially alleviates implementation issues preventing the deployment of dosage regimen individualization in clinical practice. Since stochastic optimization has been extensively used in other domains, the approach for uncertainty characterization proposed in this work may have general relevance beyond the pharmacometrics domain. © 2013 American Institute of Chemical Engineers AIChE J, 59: 3296–3307, 2013 相似文献
8.
An analysis has been performed of the capacity of intermediate storage vessels required to buffer the effects of periodic
production failure. Simple analytical expressions for the limiting volume of the storage as a function of failure frequency
and system parameters have been developed for SISO storage system under the assumption that system variables were integer
number. All these simple analytical expressions are directly useful for determining the storage size and are the bases for
more advanced engineering study such as; operations research, controller design and process synthesis. 相似文献
9.
Inga Tijunelyte Julien Babinot Mohamed Guerrouache Gintaras Valincius Benjamin Carbonnier 《Polymer》2012,53(1):29-36
Macroporous polymeric monolith bearing thiol-reactive surface functionalities was prepared within micrometer-sized fused silica capillary column by photochemically-driven free radical copolymerization of N-acryloxysuccininimide and ethylene dimethacrylate in the presence of toluene as porogenic solvent, hereafter poly(NAS-co-EDMA), and subsequent surface grafting of allylamine through nucleophilic substitution reaction. The pore surface with pendant allyl moieties was further functionalized via a two-step thiol-ene click reaction with thiol-containing oligo(ethylene glycol) and mercaptoethanol, successively. The surface hydration ability, i.e. hydrophilic character, of the as-obtained monolith was evaluated as a function of the water-content of the liquid fluid environment through electrochromatographic evaluation of the retention properties of the -(O-CH2-CH2)-like surface-functionalized capillary monolith. A major result was that the so called hydrophilic interaction electrochromatographic mode was observed at a given mobile phase composition. An example is given for the separation of phenol-derivatives, with the most hydrophilic one being the most retained. In addition, the hydrophilic interaction based separation allowed for reduced analysis time as compared to the separation observed under reversed-phase separation mode using analogous monolithic stationary phase. Finally, the versatility of the thiol-ene photoaddition approach is demonstrated with an example of C18-like monolith for reversed-phase separation application. 相似文献
10.
Gintaras Palubeckis 《OR Spectrum》2012,34(1):1-21
In this paper, we deal with the single-row equidistant facility layout problem (SREFLP), which asks to find a one-to-one assignment
of n facilities to n locations equally spaced along a straight line so as to minimize the sum of the products of the flows and distances between
facilities. We develop a branch-and-bound algorithm for solving this problem. The lower bound is computed first by performing
transformation of the flow matrix and then applying the well-known Gilmore–Lawler bounding technique. The algorithm also incorporates
a dominance test which allows to drastically reduce redundancy in the search process. The test is based on the use of a tabu
search procedure designed to solve the SREFLP. We provide computational results for problem instances of size up to 35 facilities.
For a number of instances, the optimal value of the objective function appeared to be smaller than the best value reported
in the literature. 相似文献