Basal cell carcinoma (BCC) is the most common type of skin cancer and the incidence of BCC is expected to rise, with increased demand on dermatology resources. Little is known of the effect on people's lives of having skin cancer. The aim of this study was to quantify the handicap caused gy basal cell carcinomas before and after therapy. Forty-four patients (22 males, mean age = 65 yrs, range = 35-81 yrs) with 48 BCCs were recruited and 37 patients completed the study. Each patient completed the UK Sickness Impact Profile (UKSIP) and the Dermatology Life Quality Index (DLQI) at the initial visit to the dermatology clinic, 1 week after treatment and 3 months after treatment. Lesions had been present for a mean of 25 months (range = 1-240 months), their mean diameter was 9.6mm (range = 3-35mm) and the sites were head and neck (79%), trunk (17%) and limbs (4%). There was no relationship between the quality of life score and size of lesion. Overall the scores at presentation were very low, rising 1 week after treatment and falling to below the initial scores at 3 months (mean UKSIP 0.4%, 0.7%, 0.13%; mean DLQI 5.3% 8.7%, 1.2%). BCCs cause little handicap. This may explain the delay in seeking medical attention and should be considered in planning public health education about BCCs. 相似文献
Assessed the escalations in substance use over 3 yrs among 246 adolescent children of alcoholics (COAs) and 208 controls (aged 10.5–15.5 yrs). Older COAs showed the steepest escalations in drug use. Younger COAs whose fathers had continuing alcohol-related consequences showed the greatest escalations in alcohol use. Ss' beliefs about drinking restraint were related to their alcohol and drug use. Those whose alcoholic fathers had no continuing alcohol-related consequences showed the strongest relations between substance use and self-control reasons for limiting drinking, perceived risk for future drug problems, and seeing the negative effects of alcohol on someone else. These adolescents may be deterred from substance use escalations because of particular parental characteristics (e.g., mild forms of paternal alcoholism) or because of their beliefs about substance use. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
Summary
1-Octadecene (C18) was polymerized by using different metallocene catalysts. The rac-Et(Ind)2ZrC12/MAO (I) and rac-Me2Si(Ind)2ZrC12/MAO (III) presented the highest activity as compared with ra-Et(2-Me-Ind)2ZrCl2/MAO (II) and Ph2C(Flu)(Cp)ZrC12/MAO (IV) catalysts. Catalyst IV produced polymers with highest molecular weights. The microstructure of the polymers was
determined by 13C-NMR spectroscopy. Catalyst systems I, II and III produced isotactic polymers while catalyst IV produced polymers with mainly
syndiotactic structures but with large amount of stereoregular error.
Received: 21 June 2002/Revised version: 4 November 2002/ Accepted: 4 November 2002 相似文献
The catalytic performance of mono- and bimetallic Pd (0.6, 1.0 wt.%)–Pt (0.3 wt.%) catalysts supported on ZrO2 (70, 85 wt.%)–Al2O3 (15, 0 wt.%)–WOx (15 wt.%) prepared by sol–gel was studied in the hydroisomerization of n-hexane. The catalysts were characterized by N2 physisorption, XRD, TPR, XPS, Raman, NMR, and FT-IR of adsorbed pyridine. The preparation of ZrW and ZrAlW mixed oxides by sol–gel favored the high dispersion of WOx and the stabilization of zirconia in the tetragonal phase. The Al incorporation avoided the formation of monoclinic-WO3 bulk phase. The catalysts increased their SBET for about 15% promoted by Al2O3 addition. Various oxidation states of WOx species coexist on the surface of the catalysts after calcination. The structure of the highly dispersed surface WOx species is constituted mainly of isolated monotungstate and two-dimensional mono-oxotungstate species in tetrahedral coordination. The activity of Pd/ZrW catalysts in the hydroisomerization of n-hexane is promoted both with the addition of Al to the ZrW mixed oxide and the addition of Pt to Pd/ZrAlW catalysts. The improvement in the activity of Pd/ZrAlW catalysts is ascribed to a moderated acid strength and acidity, which can be correlated to the coexistence of W6+ and reduced-state WOx species (either W4+ or W0). The addition of Pt to the Pd/ZrAlW catalyst does not modify significantly its acidic character. Selectivity results showed that the catalyst produced 2MP, 3MP and the high octane 2,3-dimethylbutane (2,3-DMB) and 2,2-dimethylbutane (2,2-DMB) isomers. 相似文献
A novel route in the synthesis of Al-MCM-41 and Al-MCM-48, using tetraethoxysilane (TEOS) and sodium aluminate (NaAlO2) as Si and Al source has been obtained. The effect of surfactant nature and the synthesis conditions such as surfactant/Si ratio and hydrothermal treatment time on the formed mesostructure regularity has been studied. Different methods of template removal have also been evaluated. The samples were characterized by X-ray diffraction, nitrogen physisorption, FT-IR, and solid-state MAS NMR spectroscopy. 相似文献
To evaluate the effect of dietary factors on plasma zinc levels, dietary zinc intake was estimated and plasma levels were measured in 37 healthy young adults of low and middle socioeconomic status. Our study included 16 males aged 29 +/- 7 and 21 females aged 26 +/- 6 years. Dietary intake of zinc and protein was determined from a 24-hour dietary recall survey. Plasma zinc was measured by atomic absorption spectrophotometry. Alkaline phosphatase (AP) in plasma was also measured and the weight/height percentage for each subject calculated according to Jelliffe's standards. The average diet was composed of cereals, legumes, eggs, bread and noodles, caloric intake was 2051 +/- 154 kcal/day for men and 1767 +/- 158 (x +/- SD) kcal/day for women. The daily intake of zinc was 8.3 +/- 3.0 mg/day for males, and 9.7 +/- 2.0 mg/day for females. Cereals were the main source of zinc for men, while egg and dairy products were for women. Plasma zinc values were 82 +/- 22 micrograms/dl for men and 94 +/- 19 micrograms/dl for women (p less than 0.01). For the whole group plasma zinc concentration was 89 +/- 21 micrograms/dl. Seven males and two females had low plasma zinc values (70 micrograms/dl or less). Alkaline phosphatase (AP) levels were 110 +/- 10 IU for males and 71 +/- 4 IU for females (p less than 0.001). These values did not correlate with the zinc levels. Average weight/height was 99 +/- 18 for men, and 108 +/- 18 for females. Results indicate that on the average, in our study group plasma zinc levels were within the normal range, although they were significantly lower in men. Dietary intake of zinc was below the recommendations, being higher for women as related to values presented by men. The observed low plasma levels of zinc may be caused by a low intake, and/or poor bioavailability. 相似文献
The role of La2O3 loading in Pd/Al2O3-La2O3 prepared by sol–gel on the catalytic properties in the NO reduction with H2 was studied. The catalysts were characterized by N2 physisorption, temperature-programmed reduction, differential thermal analysis, temperature-programmed oxidation and temperature-programmed desorption of NO.
The physicochemical properties of Pd catalysts as well as the catalytic activity and selectivity are modified by La2O3 inclusion. The selectivity depends on the NO/H2 molar ratio (GHSV = 72,000 h−1) and the extent of interaction between Pd and La2O3. At NO/H2 = 0.5, the catalysts show high N2 selectivity (60–75%) at temperatures lower than 250 °C. For NO/H2 = 1, the N2 selectivity is almost 100% mainly for high temperatures, and even in the presence of 10% H2O vapor. The high N2 selectivity indicates a high capability of the catalysts to dissociate NO upon adsorption. This property is attributed to the creation of new adsorption sites through the formation of a surface PdOx phase interacting with La2O3. The formation of this phase is favored by the spreading of PdO promoted by La2O3. DTA shows that the phase transformation takes place at temperatures of 280–350 °C, while TPO indicates that this phase transformation is related to the oxidation process of PdO: in the case of Pd/Al2O3 the O2 uptake is consistent with the oxidation of PdO to PdO2, and when La2O3 is present the O2 uptake exceeds that amount (1.5 times). La2O3 in Pd catalysts promotes also the oxidation of Pd and dissociative adsorption of NO mainly at low temperatures (<250 °C) favoring the formation of N2. 相似文献
Arthroplasty outcome is influenced by the 'quality' of bone preparation for implant insertion. Surgeons face increasing choices of technique and instrumentation, yet clinical scoring methods assess the overall outcome and patient satisfaction but not the bone cuts directly. 'Quality management' of bone reshaping is needed to evaluate different bone cutting methods and computer assisted orthopaedic surgery (CAOS) systems. Analyses and experiments in this study were formulated for measurement and computation of four quantitative characteristics of bone preparation 'quality' and produced a highly condensed index for each. These represented (a) surface finish of cuts, (b) implant fit/looseness possible with the cut shape, (c) implant location/misalignment, and (d) accuracy of individual planar cuts. Assessment of synthetic bone cuts verified the robustness of the method for wide application in arthroplasty intraoperatively, in vitro and for comparing navigation systems. 相似文献
The study of behavioral and neurophysiological mechanisms involved in rat spatial cognition provides a basis for the development of computational models and robotic experimentation of goal-oriented learning tasks. These models and robotics architectures offer neurobiologists and neuroethologists alternative platforms to study, analyze and predict spatial cognition based behaviors. In this paper we present a comparative analysis of spatial cognition in rats and robots by contrasting similar goal-oriented tasks in a cyclical maze, where studies in rat spatial cognition are used to develop computational system-level models of hippocampus and striatum integrating kinesthetic and visual information to produce a cognitive map of the environment and drive robot experimentation. During training, Hebbian learning and reinforcement learning, in the form of Actor-Critic architecture, enable robots to learn the optimal route leading to a goal from a designated fixed location in the maze. During testing, robots exploit maximum expectations of reward stored within the previously acquired cognitive map to reach the goal from different starting positions. A detailed discussion of comparative experiments in rats and robots is presented contrasting learning latency while characterizing behavioral procedures during navigation such as errors associated with the selection of a non-optimal route, body rotations, normalized length of the traveled path, and hesitations. Additionally, we present results from evaluating neural activity in rats through detection of the immediate early gene Arc to verify the engagement of hippocampus and striatum in information processing while solving the cyclical maze task, such as robots use our corresponding models of those neural structures. 相似文献