排序方式: 共有7条查询结果,搜索用时 15 毫秒
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G Del Sal G Manfioletti S Gustincich E Ruaro C Schneider 《Canadian Metallurgical Quarterly》1994,16(1):134-138
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Monica Fedele Riccardo Sgarra Sabrina Battista Laura Cerchia Guidalberto Manfioletti 《International journal of molecular sciences》2022,23(2)
The transition between epithelial and mesenchymal phenotype is emerging as a key determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial cells first acquire the ability to invade the extracellular matrix and migrate into the bloodstream via transdifferentiation into mesenchymal cells, a phenomenon known as epithelial–mesenchymal transition (EMT), and then reacquire the epithelial phenotype, the reverse process called mesenchymal–epithelial transition (MET), to colonize a new organ. During all metastatic stages, metabolic changes, which give cancer cells the ability to adapt to increased energy demand and to withstand a hostile new environment, are also important determinants of successful cancer progression. In this review, we describe the complex interaction between EMT and metabolism during tumor progression. First, we outline the main connections between the two processes, with particular emphasis on the role of cancer stem cells and LncRNAs. Then, we focus on some specific cancers, such as breast, lung, and thyroid cancer. 相似文献
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AM Martelli M Riccio R Bareggi G Manfioletti G Tabellini G Baldini P Narducci V Giancotti 《Canadian Metallurgical Quarterly》1998,46(7):863-864
The intranuclear distribution of HMGI/Y proteins was analyzed by immunofluorescent staining in several cell lines using a polyclonal antibody that stained a fibrogranular network. In actively growing 3T3 fibroblasts, HMGI/Y proteins were mainly localized to heterochromatin masses, whereas in quiescent cells they were more diffusely distributed. Double labeling experiments showed a co-localization of HMGI/Y with DNA topoisomerase IIalpha. These results are in agreement with previously published biochemical data and indicate a possible involvement of HMGI/Y proteins in several nuclear functions, including chromatin organization and gene expression. 相似文献
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