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排序方式: 共有2627条查询结果,搜索用时 15 毫秒
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Pierre Santucci Christina Dedaki Alexandros Athanasoulis Laura Gallorini Anaïs Munoz Dr. Stéphane Canaan Dr. Jean-François Cavalier Dr. Victoria Magrioti 《ChemMedChem》2019,14(3):349-358
In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents. 相似文献
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Evaluation of the effect of processing on cocoa polyphenols: antiradical activity,anthocyanins and procyanidins profiling from raw beans to chocolate 下载免费PDF全文
Matteo Bordiga Monica Locatelli Fabiano Travaglia Jean Daniel Coïsson Giuseppe Mazza Marco Arlorio 《International Journal of Food Science & Technology》2015,50(3):840-848
The content and composition of anthocyanins and procyanidins in fermented cocoa beans (from different geographic origins: Ecuador, Cameroon, Ivory Coast, Ghana and Nigeria), roasted nibs, cocoa mass and chocolate were determined, beside the determination of the total antiradical capacity. Concerning geographic origin, cocoa beans and processed products from Ecuador showed the highest levels of anthocyanins, followed by Nigeria and Cameroon. Generally, as cocoa beans were further processed, the levels of anthocyanins and flavan‐3‐ols decreased. The largest observed losses of phenolics occurred during roasting. A progressive decreasing trend in polyphenol concentration was observed in the other processed samples as well. Despite the original content of polyphenols in raw cocoa beans, technological processes imply a significant impact on cocoa quality, confirming the need of specific optimisation to obtain high value chocolate. 相似文献
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M. F. Sorokïna O. M. Kanunnikova F. Z. Gil'mutdinov V. I. Kozhevnikov 《Glass and Ceramics》1996,53(1-2):11-13
The method of x-ray electron spectroscopy is used to investigate lead silicatexPbO(1 -x) · SiO2 (x - 0.3, 0.4, 0.5, 0.55, 0.667) glasses. The concentration dependences of the spectra of inner Pb4f, Si2p, and Ols levels led to the conclusion that for low contents of PbO, lead is present in the glass in the form of modifying ions, whereas in high concentrations, it plays the role of glass former. Restructuring in the glass occurs for about 50% molar concentration of PbO. The Pb - O bond in the glass is more ionic than in PbO. With an increase in the PbO content in the glass, the Pb - O bond becomes closer to that of lead monoxide, i.e., is more covalent. 相似文献
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灰度图像的子块压缩方法 总被引:2,自引:0,他引:2
从灰度图像的局部几何特性出发,把图像中像素灰度相近或相同的区域当作一个整体处理,从而达到图像压缩的目的。计算机仿真实验表明,该方法可以获得产高的压缩比和峰值信噪比,有效地消除方块效应,很好地保持目标细节,具有较高的实用价值。 相似文献
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V. F. Matyuk M. A. Mel’gui D. A. Pinchukov A. L. Lyubarets 《Russian Journal of Nondestructive Testing》2005,41(5):269-276
Results of an experimental study of the anomalous behavior of the residual-magnetization hysteresis of ferromagnetic articles that, under local magnetization and magnetization reversal in a pulsed magnetic field with a variable amplitude, were subjected to heat treatment under different conditions are reported. Parameters of the hysteresis and their dependence on the magnetization and magnetization-reversal conditions, as well as on the magnetic properties of a material, are considered.__________Translated from Defektoskopiya, Vol. 41, No. 5, 2005, pp. 3–13.Original Russian Text Copyright © 2005 by Matyuk, Mel’gui, Pinchukov, Lyubarets.All papers in this issue are devoted to the 100th anniversary of the birth of the late M.N. Mikheev, corresponding member of the Russian Academy of Sciences and one of the founders of magnetic structural analysis. 相似文献
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Nguyen-Huy Dung Pardo Marie-Paule Dogguy.Smiri Leïla 《Materials Research Bulletin》1982,17(3):293-300
The Mn0.23Ga1.85S3 phase belongs to the solid solution , stable at low temperature in the Ga2S3MnS system. It is hexagonal superstructure of the wurtzite, with the Ga2S3α′ type (; Z = 6; space groupe P61 or P65). Its crystal structure has been refined by the least squares method to a final R = 0.06 with 323 independant reflections. This structure is closely related to Ga2S3 α described by Hahn and Frank, and differs only by the partial occupation of the vacant metal site of Ga2S3 by Mn atoms in statistical disorder. 相似文献
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In this paper we consider two performance modelling techniques from the perspectives of model construction, generation of
an underlying continuous time Markov process, and the potential for reduction in the Markov process. Such careful comparison
of modelling techniques allows us to appreciate the strengths and weaknesses of different approaches, and facilitates cross-fertilization
between them. In the present case we take a characteristic of one formalism, functional rates in Stochastic Automata Networks,
and introduce it to the other formalism, Performance Evaluation Process Algebra. We investigate the benefits of this cross-fertilization,
particularly from the perspectives of Markov process generation and reduction. 相似文献