Corrosion-resistant lightweight metallic bipolar plates for PEM fuel cells

Corrosion resistant treated metal bipolar plates with higher rigidity and electrical conductivity than graphite were developed and tested for PEM fuel cell applications. Six replicas of single cells were used three of which were made of graphite composites bipolar plates and the other three of the treated metallic plates. A Membrane Electrode Assembly (MEA) with 5.55 cm² active electrode areas, 0.3 mg cm^–2 Pt loading and Nafion membrane 115 was fitted to each cell and operated under identical conditions. The experimental testing was conducted at room temperature (20 °C). The average value of the data obtained for the three graphite cells was plotted. Similarly, the average value of the data obtained for the three treated metal cells was plotted on the same graph for comparison. Generally, the treated metal bipolar plate provided at least 12% saving in hydrogen consumption in comparison to graphite. This is attributed to the lower bulk and surface contact resistance of the metal used in this study in relation to graphite. The results of lifetime testing, conducted at room temperature under variable loading showed no indication of power degradation due to metal corrosion for at least 1500 hours.     

Reference Range Estimation: Accounting for Measurement System Errors

Reference range is a statistic that is used in health related fields to represent the range of the most likely values for a variable of interest. Based on this range, individuals are classified as being healthy or unhealthy. In biostatistics, the reference range is calculated as the (1 ? α)% prediction interval, where this prediction interval is based on the estimated population variance from the data. Such estimation of population variance is not precise, because obtained test results do usually have errors associated with them. These errors are due to the imprecise test procedure or gauge used. In this paper, the total variability in the data is decomposed into two categories. The first is the patient‐to‐patient variability and the other is the variability due to the measurement system used. Estimation of the two kinds is performed through a gauge repeatability and reproducibility study, then the reference range is calculated, taking into account only the patient‐to‐patient variability. The revised reference range procedure is illustrated through a case study of vitamin B12 test results. A closed form formula is given to calculate the probability of a given test result being within the revised reference range. Copyright © 2015 John Wiley & Sons, Ltd.     

CNLs for the semantic web: a state of the art

One of the core challenges for building the semantic web is the creation of ontologies, a process known as ontology authoring. Controlled natural languages (CNLs) propose different frameworks for interfacing and creating ontologies in semantic web systems using restricted natural language. However, in order to engage non-expert users with no background in knowledge engineering, these language interfacing must be reliable, easy to understand and accepted by users. This paper includes the state-of-the-art for CNLs in terms of ontology authoring and the semantic web. In addition, it includes a detailed analysis of user evaluations with respect to each CNL and offers analytic conclusions with respect to the field.     

A recursive algorithm for generating the equations of motion of spatial mechanical systems with application to the five-point suspension

In this paper, a recursive formulation for generating the equations of motion of spatial mechanical systems is presented. The rigid bodies are replaced by a dynamically equivalent constrained system of particles which avoids introducing any rotational coordinates. For the open-chain system, the equations of motion are generated recursively along the serial chains using the concepts of linear and angular momenta. Closed-chain systems are transformed to open-chain systems by cutting suitable kinematic joints and introducing cut-joint constraints. The formulation is used to carry out the dynamic analysis of multi-link five-point suspension. The results of the simulation demonstrate the generality and simplicity of the proposed dynamic formulation.     

A Multistage In Silico Study of Natural Potential Inhibitors Targeting SARS-CoV-2 Main Protease

Among a group of 310 natural antiviral natural metabolites, our team identified three compounds as the most potent natural inhibitors against the SARS-CoV-2 main protease (PDB ID: 5R84), M^pro. The identified compounds are sattazolin and caprolactin A and B. A validated multistage in silico study was conducted using several techniques. First, the molecular structures of the selected metabolites were compared with that of GWS, the co-crystallized ligand of M^pro, in a structural similarity study. The aim of this study was to determine the thirty most similar metabolites (10%) that may bind to the M^pro similar to GWS. Then, molecular docking against M^pro and pharmacophore studies led to the choice of five metabolites that exhibited good binding modes against the M^pro and good fit values against the generated pharmacophore model. Among them, three metabolites were chosen according to ADMET studies. The most promising M^pro inhibitor was determined by toxicity and DFT studies to be caprolactin A (292). Finally, molecular dynamics (MD) simulation studies were performed for caprolactin A to confirm the obtained results and understand the thermodynamic characteristics of the binding. It is hoped that the accomplished results could represent a positive step in the battle against COVID-19 through further in vitro and in vivo studies on the selected compounds.     

An efficient multi-predictor reversible data hiding algorithm based on performance evaluation of different prediction schemes

Multimedia Tools and Applications - With the broad development and evolution of digital data exchange, security has become an important issue in data storage and transmission since digital data can...     

Image watermarking based on inter-tree coefficients differencing in paired wavelet-packets tree constructions

Multimedia Tools and Applications - Recently, image watermarking has been used as a tremendous mean for copyright protection of images and multimedia as well. This work presents an image...     

Linear circuits: a measurement‐based approach

This paper proposes a new measurement‐based approach that can solve synthesis problems in unknown linear circuits. The method makes use of a small number of measurements to determine the functional dependency of any circuit signal or variable on any set of design variables. Once the functional dependency is obtained, the design requirements can be applied to find the design parameter values. The results are described for linear direct current and alternating current circuits. Copyright © 2013 John Wiley & Sons, Ltd.     

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021

Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis of MetS encompasses multiple genetic and acquired entities that fall under the umbrella of insulin resistance and chronic low-grade inflammation. If left untreated, MetS is significantly associated with an increased risk of developing diabetes and cardiovascular diseases (CVDs). Given that CVDs constitute by far the leading cause of morbidity and mortality worldwide, it has become essential to investigate the role played by MetS in this context to reduce the heavy burden of the disease. As such, and while MetS relatively constitutes a novel clinical entity, the extent of research about the disease has been exponentially growing in the past few decades. However, many aspects of this clinical entity are still not completely understood, and many questions remain unanswered to date. In this review, we provide a historical background and highlight the epidemiology of MetS. We also discuss the current and latest knowledge about the histopathology and pathophysiology of the disease. Finally, we summarize the most recent updates about the management and the prevention of this clinical syndrome.