Über die Anwendung von Ionensensitiven Feldeffekttransistoren zur Untersuchung von Korrosionsvorgängen

On the application of ion sensitive field-effect transistors for the investigation of corrosion phenomena Ion sensitive field-effect transistors (ISFET) are chemical sensors based on semiconductor technology. They exhibit small dimensions, a plane measuring surface and have short response times. Thus, they are very suitable for the determination of local changes of the pH value at electrochemical corrosion studies. The described in this paper experimental set-up allows in situ measurements of the pH value by means of ISFET sensors in amounts of liquids below 1 mm³; the active surface area of the material under test may be below 1 mm². In model tests preferably changes of the pH value of dist. water due to the corrosion of steel St 38 have been investigated. After an initial short-time rise caused by oxygen reduction a decay of the pH value to pH = 3 ?4 was obseved. Furthermore, ISFET sensors have been used as a potential probe for electrochemical polarization measurements in low conductive media. It was shown, that the dynamic behaviour of potentiostatic control circuits may be influenced favourably by the low output resistance of the ISFET.     

Stability of proximal femoral grafts in canine hip arthroplasty

In a canine model, the fixation stability of a prosthesis and proximal bone graft composite were measured relative to the distal femur. One group had the prosthesis graft composite cemented into the distal femur. The second group had the prosthesis graft composite press fit into the distal femur for biologic ingrowth. Displacements of the proximal femoral grafts relative to the host bone in each group were measured after ex vivo (acute with graft) implantation and 4 months after implantation. A third group with no osteotomy (acute intact) simulated perfect graft to host bone union. Relative displacements representing 6 degrees freedom (translation and rotation) were calculated from the displacement values measured by 9 eddy current transducers. Measurements of displacement were used to test the hypothesis that distal press fit fixation equals distal cement fixation at 4 months after implantation. In all cases the measured translations and rotations of the graft to implant construct were small and of a magnitude that should encourage bone ingrowth (< 0.05 mm and < 0.1 degree, respectively). The stability of the press fit group at 4 months was not significantly different from the cemented group in axial and transverse displacement during axial and transverse loading, respectively. There was no difference in stabilities at 4 months between distal press fit and cemented fixation in hip replacements requiring a proximal femoral graft.     

New energy transfer dyes for DNA sequencing

We have synthesized a set of four energy transfer dyes and demonstrated their use in automated DNA sequencing. The donor dyes are the 5- or 6-carboxy isomers of 4'-aminomethylfluorescein and the acceptor dyes are a novel set of four 4,7-dichloro-substituted rhodamine dyes which have narrower emission spectra than the standard, unsubstituted rhodamines. A rigid amino acid linker, 4-aminomethylbenzoic acid, was used to separate the dyes. The brightness of each dye in an automated sequencing instrument equipped with a dual line argon ion laser (488 and 514 nm excitation) was 2-2.5 times greater than the standard dye-primers with a 2 times reduction in multicomponent noise. The overall improvement in signal-to-noise was 4- to 5-fold. The utility of the new dye set was demonstrated by sequencing of a BAC DNA with an 80 kb insert. Measurement of the extinction coefficients and the relative quantum yields of the dichlororhodamine components of the energy transfer dyes showed their values were reduced by 20-25% compared with the dichlororhodamine dyes alone.     

An integral system‐ergonomic approach for IT‐based process management in complex work environments by example of manufacturing and health care

Recent trends in manufacturing and health care move these two work systems closer together from a system ergonomics point of view. Individual treatment of products, especially patients, by specialists in a distributed environment demand information technology (IT)‐based support suitable for complex systems. IT‐based support of processes in complex systems is difficult due to the lack of standard processes. IT support also means to rethink processes to use efficiency potentials. Close cooperation of users and software developers is needed to increase the ergonomic quality of the system. Therefore, suitable tools are needed: UML is available as the standard industry modeling language, Zope/Plone as the quasi‐standard for content management systems, SimPy as an object‐oriented simulation tool for event‐triggered processes, and ACT‐R as a powerful cognitive architecture for simulation of human information processes. The integration of these tools enables system‐ergonomic support of processes in the complex work system as well as of the development and deployment process. It is the base of an integral system‐ergonomic approach for IT‐based process management. Knowledge gained during process analysis either enters models or leads to the extension and adaptation of the tool chain. The models serve as basis for discussion among system ergonomists, programmers, and specialists from the work system. Further, they are understood by simulation and process support tools. Transcoding efforts between humans with different professional backgrounds and machines are reduced, and the flexibility demanded by complex systems is met. © 2008 Wiley Periodicals, Inc.     

A consideration of the nature of work and the consequences for the human-oriented design of production and products

In this article, it is shown that human work can be understood as a process of creating order, and that order can be seen as a form of information. Since information can be considered as negative entropy, work is associated with energy consumption. Therefore, it is important to investigate the nature of human necessities in more detail in order to meet the desire for comfort through the efficient application of energy. Temporary increases of information cause accelerated increases in entropy. This explains the appearance of living organisms, and the historic development of increasingly complex technology. Through technical progress, repetitive human work is being replaced by automation, so that primarily creative work remains. Now the question arises of how much creative work a human can manage. In addition, one goal of automation should be the reduction of human errors, but in doing so, an optimal balance should be found between supporting the operator both during normal procedures and during unforeseen circumstances.     

„Medizinische Notwendigkeit“: Herausforderungen eines unscharfen Begriffs

Definition of the problem

“Medical necessity” (MedN) is the central regulatory concept for decisions about which services are covered by German statutory health insurance. Despite its seeming objectivity and dependence on physicians’ expert judgment, the concept is by no means clearly defined.

Arguments

In this first of five planned papers on the conceptual analysis of MedN from the perspectives of philosophy and ethics of medicine, law, and (social) medicine, the focus lies on systemizing ongoing controversies.

Conclusion

Our goal is to come up with a so far missing foundation for detailed debates. We aim to clarify MedN’s conceptual structure, function, contextuality, and ambiguities as well as the fundamental limits of conceptual investigations for the normative questions at issue of regulating medical services.

     

Gun Propulsion Concepts. Part II: Solid and Liquid Propellants

The present paper deals with both the conventional solid propellant and modern liquid propellant gun concepts. Solid propellant guns, known since the 14th century, are still being investigated, although this concept represents a relative mature technology. Thus any progress is predominantly a refinement of existing techniques. Comparatively, liquid propellant gun research and development address a rather new technique and invoke some improvements over conventional solid propellant systems. Especially, automatic system are easier to design, artillery zoning is more easily achieved, cartridge disposal is avoided, and high-energetic liquid propellants or special system designs offer higher performance. Therefore, the liquid propellant gun technology seems to be a near-term technology that, complementary to solid propellant gun concepts, might play a role in future armament.     

Investigation of Liquid Gun Propellants: Electrical ignition of LGP 1846

Progress achieved in the study of the electrical ignition of the hydroxylammonium nitrate(HAN)-based liquid gun propellant LGP 1846 is described. The goal of the work is to develop an igniter system suitable for regenerative liquid propellant guns. Several igniter configurations of the one- as well as the two-stage types designed by the Ballistic Research Laboratory and the Fraunhofer-Institut EMI-AFB, have been tested. Voltage and current as well as the pressure histories were recorded. Calculations of electrostatic field distributions discussed here were obtained by a finite element code implemented at Dynamit Nobel. The theoretical analysis yielded alternative electrode designs for future testing. In addition, a specially designed igniter chamber equipped with sapphire windows was used at EMJ-AFB to study the fundamentals of the electrical discharge by means of high-speed photography.     

Evolution of MicroRNA Biogenesis Genes in the Sterlet (Acipenser ruthenus) and Other Polyploid Vertebrates

MicroRNAs play a crucial role in eukaryotic gene regulation. For a long time, only little was known about microRNA-based gene regulatory mechanisms in polyploid animal genomes due to difficulties of polyploid genome assembly. However, in recent years, several polyploid genomes of fish, amphibian, and even invertebrate species have been sequenced and assembled. Here we investigated several key microRNA-associated genes in the recently sequenced sterlet (Acipenser ruthenus) genome, whose lineage has undergone a whole genome duplication around 180 MYA. We show that two paralogs of drosha, dgcr8, xpo1, and xpo5 as well as most ago genes have been retained after the acipenserid-specific whole genome duplication, while ago1 and ago3 genes have lost one paralog. While most diploid vertebrates possess only a single copy of dicer1, we strikingly found four paralogs of this gene in the sterlet genome, derived from a tandem segmental duplication that occurred prior to the last whole genome duplication. ago1,3,4 and exportins1,5 look to be prone to additional segment duplications producing up to four-five paralog copies in ray-finned fishes. We demonstrate for the first time exon microsatellite amplification in the acipenserid drosha2 gene, resulting in a highly variable protein product, which may indicate sub- or neofunctionalization. Paralogous copies of most microRNA metabolism genes exhibit different expression profiles in various tissues and remain functional despite the rediploidization process. Subfunctionalization of microRNA processing gene paralogs may be beneficial for different pathways of microRNA metabolism. Genetic variability of microRNA processing genes may represent a substrate for natural selection, and, by increasing genetic plasticity, could facilitate adaptations to changing environments.     

Nanohybrid Materials with Tunable Birefringence via Cation Exchange in Polymer Films

In this work, a nanohybrid material based on a freestanding polymeric liquid crystal network capable of postmodification via cation exchange to tune birefringence is proposed. The smectic liquid crystal films can be infiltrated with a variety of cations, thereby changing the refractive indices (n_e and n_o) and the effective birefringence (Δn) of the nanohybrid material, with reversible cation infiltration occurring within minutes. Birefringence could be tuned between values of 0.06 and 0.19, depending on the cation infiltrated into the network. Upon infiltration, a decrease in the smectic layer spacing is found with layer contraction independent of the induced change in birefringence. Potential applications are in the field of specialty optical devices, such as flexible, retunable reflective filters.