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排序方式: 共有1139条查询结果,搜索用时 15 毫秒
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Konstantin V. Dergilev Evgeny K. Shevchenko Zoya I. Tsokolaeva Irina B. Beloglazova Ekaterina S. Zubkova Maria A. Boldyreva Mikhail Yu. Menshikov Elizaveta I. Ratner Dmitry Penkov Yelena V. Parfyonova 《International journal of molecular sciences》2020,21(24)
Cell therapy of the post-infarcted myocardium is still far from clinical use. Poor survival of transplanted cells, insufficient regeneration, and replacement of the damaged tissue limit the potential of currently available cell-based techniques. In this study, we generated a multilayered construct from adipose-derived mesenchymal stromal cells (MSCs) modified to secrete stem cell factor, SCF. In a rat model of myocardium infarction, we show that transplantation of SCF producing cell sheet induced activation of the epicardium and promoted the accumulation of c-kit positive cells in ischemic muscle. Morphometry showed the reduction of infarct size (16%) and a left ventricle expansion index (0.12) in the treatment group compared to controls (24–28%; 0.17–0.32). The ratio of viable myocardium was more than 1.5-fold higher, reaching 49% compared to the control (28%) or unmodified cell sheet group (30%). Finally, by day 30 after myocardium infarction, SCF-producing cell sheet transplantation increased left ventricle ejection fraction from 37% in the control sham-operated group to 53%. Our results suggest that, combining the genetic modification of MSCs and their assembly into a multilayered construct, we can provide prolonged pleiotropic effects to the damaged heart, induce endogenous regenerative processes, and improve cardiac function. 相似文献
3.
Felix Rivkin Irina Kuznetsova Nadezhda Ivanova Sergey Suhodolsky 《Soil Mechanics and Foundation Engineering》2002,39(1):42-43
Soil Mechanics and Foundation Engineering - 相似文献
4.
The standard impact factor as an evaluation tool of science fields and scientific journals 总被引:2,自引:2,他引:0
Irina Marshakova-Shaikevich 《Scientometrics》1996,35(2):283-290
The standard impact factor for particular fields of science (Ig) and the relative impact factor K for scientific journals are introduced. The technique of calculation of standard impact factor (Ig) for a field is an inherent part of a method which allows a cross-field evaluation of scientific journals. This method for evaluating scientific journals elaborated in 1988 was aimed at the analysis of Russian journals covered by the SCI database, it was also used for chemical journals (more that 300) and for journals in the Life sciences (more than 1000). The results are discussed. 相似文献
5.
Quantum-mechanical reaction rate constants were calculated from centroid molecular dynamics (CMD) simulations, for the case of barrier crossing in an asymmetrical double-well potential bilinearly coupled to a harmonic bath. The calculation is based on a recently proposed formulation of the reaction rate constant in terms of the position—flux correlation function, which can be approximated via CMD in a well-defined manner. The predictions of CMD and various simplified versions of it are compared to exact results, which were obtained via the quasi-adiabatic propagator path integral (QUAPI) method, and/or path integral quantum transition state theory (PI-QTST). The predictions based on CMD are found to be in good agreement with both. 相似文献
6.
The design of controlled-resistance loads for domestic induction heating applications using thin non-magnetic conductive layers is described. Thin metallic layers are fabricated using the phase vapour deposition technique. Such layers would enable vessels, the inductive behaviour of which was similar to those fabricated with conventional ferromagnetic bulk materials, to be manufactured. Optimum layer thickness is investigated using an analytical impedance model of the complete induction system 相似文献
7.
Irina Naydenova Torleiv Klove 《IEEE transactions on information theory / Professional Technical Group on Information Theory》2007,53(3):1188-1193
Bose and Lin introduced a class of systematic codes for detection of binary asymmetric errors. In this note, we describe a generalization to q-ary asymmetric error detecting codes. For these codes, the possible undetectable errors are characterized and the undetectable errors of minimum weight are determined 相似文献
8.
Responds to commentary by I. Silverman (see record 2007-08963-001) entitled "Review of Pure types are rare": Comment on book review. I do not think that either one of us will change his position, and therefore it is up to the interested (yet disinterested) reader to adjudicate our dispute by checking Professor Silverman's book and his references. In the process, the reader will be forced to consider the thought-provoking implications for our mental health system of some of the incidents which the author describes so vividly, and that will not be a bad thing. There is one point, however, which is worth pursuing further here, for Professor Silverman persists in an elementary statistical fallacy. Let us take the situation which he cites, where the base rate for diagnosing schizophrenia is 50%. Suppose with the same base rate the degree of agreement is in fact 53%; this is far above chance level. It must be emphasized, however, that the 53% agreement under discussion came not from a study where the base rate for diagnosing schizophrenia was 50%, but from one where the conditions were far more stringent since the base rate for diagnosing schizophrenia was around 20%. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Rami Dana Irina Kiruschev Phong Dinh Tran Pascal Doppelt Yishay Manassen 《Israel journal of chemistry》2008,48(2):87-97
A new design for a dual-tip scanning tunneling microscope (STM) is presented. The design is a variation on the mechanically controllable break-junction with two electron beam-induced deposition nano-tips. The new design enables one to scan surfaces simultaneously with two probes having a nano-gap separation. By collecting the lateral current flowing between the tips, the transconductance map can then be compared with the STM images for local characterizations of the electron transport. Since the lateral beam carries the property of the density of states of the surface at momentum space, the dispersion of the electronic structure should give an orientation and position dependence of the local transconductance current. In addition, the reduced terminal separation, on the order of the characteristic mesoscopic length scales, is likely to be sensitive to a variety of typically observed interactions and interference effects. 相似文献