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1.
Anna Stasiowicz Natalia Rosiak Ewa Tykarska Maciej Kozak Jacek Jenczyk Piotr Szulc Joanna Kobus-Cisowska Kornelia Lewandowska Anita Paziska Wojciech Paziski Judyta Cielecka-Piontek 《International journal of molecular sciences》2021,22(8)
Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood–brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase). 相似文献
2.
Tadeusz Zając Agnieszka Klimek-Kopyra Ryszard Mazurek Andrzej Oleksy Jacek Strojny 《Journal of Natural Fibers》2020,17(8):1199-1211
ABSTRACT Nine sowing densities of linseed were compared in a two-year experiment. Self-regulation of the density of a linseed stand resulted in a differentiated branching of the plants. The number of capsules on a linseed shoot, as well as seeds in the capsule, and the number of seeds from the shoot were highly varied from year to year, and there is even a stronger differentiation in the weight of 1000 seeds. Linear relationships were noted between the mass of seeds from the linseed plant and the number of capsules. The yield of linseed was affected by both factors. An increasing sowing rate reduced the seed yield from the shoot and the plant. At lower seeding rates, the lateral shoots contributed in the seeds yield of the plant to a higher degree compared to the main ones. 相似文献
3.
A hybrid sorbent material for removal of hydrogen sulfide from air was developed. The material is based on activated carbon and iron compounds obtained from waste iron(II) sulfate(VI) heptahydrate. The iron salt is deposited on the carbonaceous support and subjected to oxidation (Fe2+ to Fe3+) using atmospheric oxygen under alkaline conditions. An effect of H2O2 addition to the process on the composition of the resultant material was also examined. X-ray diffraction (XRD) analyses confirmed easy conversion of waste FeSO4·7H2O to iron oxides Fe3O4 and FeOOH. The activated carbon supporting iron oxides revealed a higher efficiency in H2S elimination from air compared to the commercial activated carbon, without any modification. 相似文献
4.
Aleksandra Czumaj Sylwia Szrok-Jurga Areta Hebanowska Jacek Turyn Julian Swierczynski Tomasz Sledzinski Ewa Stelmanska 《International journal of molecular sciences》2020,21(23)
The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well understood. Coenzyme A participates in more than 100 different catabolic and anabolic reactions, including those involved in the metabolism of lipids, carbohydrates, proteins, ethanol, bile acids, and xenobiotics. However, much less is known about the importance of the concentration of this cofactor in various cell compartments and the role of altered CoA concentration in various pathologies. Despite continuous research on these issues, the molecular mechanisms in the regulation of the intracellular level of CoA under pathological conditions are still not well understood. This review summarizes the current knowledge of (a) CoA subcellular concentrations; (b) the roles of CoA synthesis and degradation processes; and (c) protein modification by reversible CoA binding to proteins (CoAlation). Particular attention is paid to (a) the roles of changes in the level of CoA under pathological conditions, such as in neurodegenerative diseases, cancer, myopathies, and infectious diseases; and (b) the beneficial effect of CoA and pantethine (which like CoA is finally converted to Pan and cysteamine), used at pharmacological doses for the treatment of hyperlipidemia. 相似文献
5.
A new method for computing the node-pair reliability of network systems modeled by random graphs with nodes arranged in sequence is presented. It is based on a recursive algorithm using the “sliding window” technique, the window being composed of several consecutive nodes. In a single step, the connectivity probabilities for all nodes included in the window are found. Subsequently, the window is moved one node forward. This process is repeated until, in the last step, the window reaches the terminal node. The connectivity probabilities found at that point are used to compute the node-pair reliability of the network system considered. The algorithm is designed especially for graphs with small distances between adjacent nodes, where the distance between two nodes is defined as the absolute value of the difference between the nodes’ numbers. The maximal distance between any two adjacent nodes is denoted by Γ(G), where G symbolizes a random graph. If Γ(G)=2 then the method can be applied for directed as well as undirected graphs whose nodes and edges are subject to failure. This is important in view of the fact that many algorithms computing network reliability are designed for graphs with failure-prone edges and reliable nodes. If Γ(G)=3 then the method's applicability is limited to undirected graphs with reliable nodes. The main asset of the presented algorithms is their low numerical complexity—O(n), where n denotes the number of nodes. 相似文献
6.
aneta Polkowska Jacek Namienik Jacek Czerwiski & Bogdan Zygmunt 《International Journal of Food Science & Technology》1996,31(5):387-395
Applicability of thin-layer headspace (TLHS) procedure giving an aqueous concentrate and also classical purge and trap (PT) in off-line mode to isolate and enrich volatile organohalogen compounds in common beverages was tested. Both enrichment tech-niques were used in combination with gas chromatography – electron capture detection (GC-ECD). TLHS, combined with direct aqueous injection (DAI)-GC-ECD, proved applicable in the determination of volatile organohalogen compounds in all studied beverages, while the PT in a version with no preliminary sample pre-treatment was of limited applicability. Detection limits of the TLHS-based procedure were in the order of 1 ppt. Content of volatile organohalogen compounds in a number of beverages available on the Polish market including mineral waters, beers, juices, carbonated and non-carbonated soft drinks, etc. was determined by means of TLHS-DAI-GC-ECD. 相似文献
7.
In this paper an analytical method for determining the permeability of nonwoven filter fabrics is presented. The derived formula shows that the intrinsic permeability, fully characterizing the porous medium, depends on fabric porosity, n, fibre diameter, d, and a shape factor determined experimentally. 相似文献
8.
Andrzej Malag Jacek Ratajczak Jerzy Gazecki 《Materials Science and Engineering: B》1993,20(3):332-338
Selective wet chemical etching of the AlxGa1−xAs/GaAs system has been applied to heterostructure characterization. Samples of LPE grown AlGaAs/GaAs laser double-heterostructures and separate confinement heterostructures as well as antiresonant reflecting optical waveguides heterostructures were treated with “I2 solution” (I2:KI:H2O) and hydrochloric acid. These compounds selectively etch the ternary AlxGa1−xAs layers, but with different “threshold composition” xth values (the x value is that above which the etching rate of a given compound increases sharply). Selectively etched samples have been examined by SEM. The experimental dependence of etching rate on the x value for I2 solution has been derived. From this dependence, the x composition of any ternary layer can be estimated simply. Observations were made of the “microscopic” properties of the heterostructure, such as the smoothness of the interfaces and the uniformity of layers. All imperfections resulting from the growth process, such as interface perturbations or compositional nonuniformity of layers, are clearly seen. An additional advantage of this etching technique is its simplicity. It allows quick examination of grown heterostructure for the selection of wafers for further processing. 相似文献
9.
Jerzy Stangierski Jan Zabielski Jacek Kijowski 《European Food Research and Technology》2007,226(1-2):233-237
The effect of addition of 3 g/L of commercially available transglutaminase preparation to protein extracts obtained from mechanically
recovered poultry meat was studied. The content of free thiol groups (–SH), thermal drip and gel texture were determined.
After pre-incubation at 7–8 °C for 1, 3, 5 and 24 h, the samples were subjected to one-step heating at 50, 60, 70 and 80 °C
and two-step heating at 50/80, 55/80 and 60/80 °C. The addition of preparation and the extension of pre-incubation time led
to decrease of free -SH groups content. After heating, the number of thiol groups decreased, the texture was improved, but
thermal drip from gels increased. The amount of –SH groups in gel extracts subjected to one-step heating decreased with simultaneous
increase of mechanical strength of gels. Protein gels subjected to two-step heating exhibited higher firmness than gels subjected
to one-step heating. Thus, the 3 g/L addition of transglutaminase preparation in combination with one-step thermal processing
at 70 °C and pre-incubation for 3 h contributed to improvement of texture properties of model gels and low thermal drip. 相似文献
10.
Malgorzata Kloc Ahmed Uosef Jacek Z. Kubiak Rafik Mark Ghobrial 《International journal of molecular sciences》2021,22(1)
The development, progression, or stabilization of the atherosclerotic plaque depends on the pro-inflammatory and anti-inflammatory macrophages. The influx of the macrophages and the regulation of macrophage phenotype, inflammatory or anti-inflammatory, are controlled by the small GTPase RhoA and its downstream effectors. Therefore, macrophages and the components of the RhoA pathway are attractive targets for anti-atherosclerotic therapies, which would inhibit macrophage influx and inflammatory phenotype, maintain an anti-inflammatory environment, and promote tissue remodeling and repair. Here, we discuss the recent findings on the role of macrophages and RhoA pathway in the atherosclerotic plaque formation and resolution and the novel therapeutic approaches. 相似文献