Evaluation of ‘green’ synthesis and biological activity of gold nanoparticles using Tragopogon dubius leaf extract as an antibacterial agent

Currently, the use of ‘green’ synthesised nanoparticles with environmentally friendly properties is considered a novel therapeutic approach in medicine. Here, the authors evaluated gold nanoparticles (AuNPs) conjugated with Tragopogon dubius leaf extract and their antibacterial activity in vitro and in vivo. Colour changes from yellow to dark brown and a peak at 560 nm on ultraviolet–visible spectroscopy confirmed the formation of nanoparticles. Additionally, transmission electron microscopy, X‐ray diffraction, and Fourier transform infrared spectroscopy analyses were performed to determine particle sizes and functional groups involved in gold reduction. Moreover, using standard micro‐dilution and disc‐diffusion assays against Klebsiella pneumoniae, Bacillus cereus, Escherichia coli, and Staphylococcus aureus, the antimicrobial properties of synthesised AuNPs were investigated. To confirm antibacterial activity, synthesised AuNPs were applied in a rat model on burn wounds infected with S. aureus, and the nanoparticles were as effective as tetracycline in bacterial reduction and wound healing. In conclusion, the synthesis of AuNPs with aqueous T. dubius extract was rapid, simple, and inexpensive, and the synthesised nanoparticles had significant antibacterial activity in vitro and in vivo.Inspec keywords: transmission electron microscopy, wounds, nanoparticles, ultraviolet spectra, reduction (chemical), particle size, nanofabrication, gold, X‐ray diffraction, antibacterial activity, microorganisms, visible spectra, nanomedicine, biomedical materials, Fourier transform infrared spectraOther keywords: biological activity, gold nanoparticles, antibacterial agent, therapeutic approach, colour changes, ultraviolet–visible spectroscopy, transmission electron microscopy, gold reduction, antimicrobial properties, Fourier transform infrared spectroscopy analyses, disc‐diffusion assay, green synthesis, Tragopogon dubius leaf, in vitro antibacterial activity, in vivo antibacterial activity, X‐ray diffraction, particle sizes, functional groups, standard microdilution assay, burn wounds, S. aureus, tetracycline, bacterial reduction, wound healing, wavelength 560.0 nm     

Integrating building information modelling with sustainability to design building projects at the conceptual stage

Lately the construction industry has become more interested in designing and constructing environmentally friendly buildings (e.g. sustainable buildings) that can provide both high performance and monetary savings. In general, sustainability integrates the following three related components: (1) environmental, (2) economic, (3) social well-being. Incorporating these components at the conceptual stage is achieved by using sustainable design, through which designers must identify associated materials and systems based on any selected certification (rating) system. The use of building information modelling (BIM) concepts helps engineers design digital models that allow owners to visualize the building before the physical implementation takes place. To apply BIM concepts, designers use tools to create 3D models of buildings where the design materials and systems are selected from the built-in database of these tools. Designers will not be able to quantify the environmental impacts of these materials to support the decisions needed to design sustainable buildings due to the following reasons: (1) a lack of information about the sustainable materials that are stored in the database, (2) a lack of interoperability between the design and analysis tools that enable full life cycle assessments (LCAs) of buildings. This paper presents a methodology that integrates BIM and LCA tools with a database for designing sustainable building projects. The methodology describes the development and implementation of a model that incorporates a database in which information about sustainable materials is stored and linked to a BIM (3D) module along with an LCA module and a certification and cost module. The goal of this model is to simplify the process of creating sustainable designs and to evaluate the environmental impacts (EI) of newly designed buildings at the conceptual stage of their life. An actual building project is presented in order to illustrate the usefulness and capabilities of the developed model.     

Processing and performance properties of amino silicone-based softener on various textile substrates

Polymer Bulletin - According to recent researches, the emulsion stability, characteristics and the particle size distribution have great importance in their ability to impart desired surface...