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排序方式: 共有63条查询结果,搜索用时 15 毫秒
1.
Scientometrics - Using a selection of general science journals, general medical journals and specialized medical journals, this paper analyses four indicators of epistemic community formation:... 相似文献
2.
Inga Baasch Christensen Lei Cheng Jonathan R. Brewer Udo Bartsch Robert A. Fenton Helle H. Damkier Jeppe Praetorius 《International journal of molecular sciences》2021,22(4)
(1) Background: The unusual accumulation of Na,K-ATPase complexes in the brush border membrane of choroid plexus epithelial cells have intrigued researchers for decades. However, the full range of the expressed Na,K-ATPase subunits and their relation to the microvillus cytoskeleton remains unknown. (2) Methods: RT-PCR analysis, co-immunoprecipitation, native PAGE, mass spectrometry, and differential centrifugation were combined with high-resolution immunofluorescence histochemistry, proximity ligase assays, and stimulated emission depletion (STED) microscopy on mouse choroid plexus cells or tissues in order to resolve these issues. (3) Results: The choroid plexus epithelium expresses Na,K-ATPase subunits α1, α2, β1, β2, β3, and phospholemman. The α1, α2, β1, and β2, subunits are all localized to the brush border membrane, where they appear to form a complex. The ATPase complexes may stabilize in the brush border membrane via anchoring to microvillar actin indirectly through ankyrin-3 or directly via other co-precipitated proteins. Aquaporin 1 (AQP1) may form part of the proposed multi-protein complexes in contrast to another membrane protein, the Na-K-2Cl cotransporter 1 (NKCC1). NKCC1 expression seems necessary for full brush border membrane accumulation of the Na,K-ATPase in the choroid plexus. (4) Conclusion: A multitude of Na,K-ATPase subunits form molecular complexes in the choroid plexus brush border, which may bind to the cytoskeleton by various alternative actin binding proteins. 相似文献
3.
Service Composition Issues in Pervasive Computing 总被引:2,自引:0,他引:2
Providing new services by combining existing ones—or service composition—is an idea pervading pervasive computing. Pervasive computing technologies seek to concurrently exhibit context awareness, manage contingencies, leverage device heterogeneity, and empower users. These four goals prompt service-composition-mechanism design requirements that are unique to pervasive computing. This article catalogs service composition mechanisms and describes their variation points, which indicate how well the resulting compositions meet the four goals. 相似文献
4.
Jeppe Rich Carlo Giacomo PratoTove Hels Allan LyckegaardNiels Buus Kristensen 《Accident; analysis and prevention》2013
While the number of fatalities on Danish roads has decreased in the last 40 years, research has not investigated the contribution of legislation changes, enforcement measures, technological enhancements, infrastructural improvements and human factors to this reduction. In the context of a Danish car market with remarkably high registration tax that causes potential buyers to hold longer onto old cars, the relationship between technological enhancements of vehicles and severity of crashes requires particular attention. 相似文献
5.
Sudden cardiac death (SCD) is a major cause of mortality in Western countries. Furthermore, SCD is often the first manifestation of coronary artery disease, making it difficult to prevent. Heart rate variability (HRV), which can be determined by extended recording of the heart rate by 24-h Holter monitoring, has been shown to be one of the best predictors of the risk of SCD. There is increasing evidence from animal experiments and clinical trials in humans that n?3 fatty acids reduce the risk of SCD. We have studied the effect of n?3 fatty acids on HRV and present data clearly showing that n?3 fatty acids increase HRV. This adds further to the hypothesis that an increased intake of n?3 fatty acids may reduce the risk of SCD. 相似文献
6.
Erik Berg Schmidt Jeppe Hagstrup Christensen Inge Aardestrup Trine Madsen Sam Riahi Vibeke Ellegaard Hansen Helle Aarup Skou 《Lipids》2001,36(1):S65-S68
There is some evidence from epidemiology that intake of n-3 polyunsaturated fatty acids (PUFA) from seafood may protect against coronary artery disease (CAD). This hypothesis is further supported from animal data showing a beneficial effect of n-3 PUFA on thrombosis and atherosclerosis in animals fed fish oils in most, but not all, studies. There are several mechanisms by which an increased intake of marine n-3 PUFA may protect against CAD; the most universal finding is a reduction of plasma triglycerides. It is puzzling, however, that a very low amount of n-3 PUFA, with no known beneficial biochemical effects, seems to be cardioprotective. It has therefore been of paramount interest to perform clinical trials. Such evidence and trials are discussed in later chapters, and the results have been very encouraging. 相似文献
7.
Aggregation‐Prone Amyloid‐β⋅CuII Species Formed on the Millisecond Timescale under Mildly Acidic Conditions
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Prof. Dr. Jeppe T. Pedersen Christian B. Borg Thomas C. T. Michaels Dr. Tuomas P. J. Knowles Prof. Dr. Peter Faller Prof. Dr. Kaare Teilum Prof. Dr. Lars Hemmingsen 《Chembiochem : a European journal of chemical biology》2015,16(9):1293-1297
Metal ions and their interaction with the amyloid beta (Aβ) peptide might be key elements in the development of Alzheimer's disease. In this work the effect of CuII on the aggregation of Aβ is explored on a timescale from milliseconds to days, both at physiological pH and under mildly acidic conditions, by using stopped‐flow kinetic measurements (fluorescence and light‐scattering), 1H NMR relaxation and ThT fluorescence. A minimal reaction model that relates the initial CuII binding and Aβ folding with downstream aggregation is presented. We demonstrate that a highly aggregation prone Aβ ? CuII species is formed on the sub‐second timescale at mildly acidic pH. This observation might be central to the molecular origin of the known detrimental effect of acidosis in Alzheimer's disease. 相似文献
8.
为在高度竞争的商业环境中保持市场份额,服务供应商面临不断提高性能和服务水平。同时还需要不断引入能够增加营收的新业务平台。所有这些因素都需要在路由器中实现高级的分组处理功能。这需要路由器具有高度的灵活性和可扩展能力,并推动了专用器件,如网络处理器(NP)的市场发展。 相似文献
9.
Jeppe Rass‐Hansen Hanne Falsig Betina Jørgensen Claus H Christensen 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2007,82(4):329-333
Increasing amounts of bioethanol are being produced from fermentation of biomass, mainly to counteract the continuing depletion of fossil resources and the consequential escalation of oil prices. Today, bioethanol is mainly utilized as a fuel or fuel additive in motor vehicles, but it could also be used as a versatile feedstock in the chemical industry. Currently the production of carbon‐containing commodity chemicals is dependent on fossil resources, and more than 95% of these chemicals are produced from non‐renewable carbon resources. The question is: what will be the optimal use of bioethanol in a longer perspective? Copyright © 2007 Society of Chemical Industry 相似文献
10.