The ground water behaviour pattern and foundation stabilisation practice at hartebeestfontein

Hartebeestfontein Gold Mining Company Limited, which produces 100 kg of gold per working day, has a mining lease area situated mainly over dolomite. A major river nearby governs the regional drainage. The formation of sinkholes and dolines, caused by fluctuations in the water table and the flow of water underground, often accelerated as the result of unavoidable or inadvertent surface activities, is common in such terranes. To maintain production, meticlous ground investigations under new installations plus periodic re-examination and stabilisation under existing ones, particularly key installations, is necessary. The local ground water behaviour pattern is controlled by three impervious major dykes and two major fissure zones, the latter draining surface water into the mine workings. Monthly water table measurements over 25 years show a steady rise to a limit over the area of one fissure zone and a drastic lowering over the other. The value of gravity techniques and thermal infra-red line scanning for cavity detection in the Hartebeestfontein context, is discussed. The procedures followed, for stabilising ground and foundations, are illustrated by means of case histories. The extension of the techniques, learnt from the stabilisation experience, to limiting water seepage into shafts sunk through dolomite, is also discussed.     

COPD: using nutrition to prevent respiratory function decline

Close to three-fourths of patients with chronic obstructive pulmonary disease (COPD) suffer from weight loss. Identifying a single cause for this is difficult, as several factors-including chronic mouth breathing, dyspnea, aerophagia, certain medications, and depression-often act in concert. Malnutrition can exacerbate symptoms of COPD by decreasing ventilatory muscle strength, exercise tolerance, and immunocompetence, and by increasing the risk of depression and anxiety. Goals of nutrition intervention are to prevent or reverse malnutrition without worsening the disease process and to improve respiratory function, thereby reducing morbidity and delaying mortality. Recommendations for intake of fats, carbohydrates, protein, and water must be individualized.     

Applicant reactions to face-to-face and technology-mediated interviews: A field investigation.

This field study examined applicant reactions (N = 802) toward face-to-face as compared with technology-mediated interviews (through videoconferencing or by telephone) for 346 organizations. Face-to-face interviews were perceived as more fair and led to higher job acceptance intentions than were videoconferencing and telephone interviews. Perceived interview outcomes were higher with face-to-face and telephone interviews over videoconferencing. Self-monitoring moderated the relationship between interview medium and perceptions of fairness. Specifically, this relationship was (a) positive for face-to-face, (b) negative for telephone, and (c) nonsignificant for videoconferencing interviews. Moreover, the number of offers an applicant received moderated the relationship between interview medium over, and perceived fairness. The relationship between number of offers and perceived fairness was positive for face-to-face and negative for technology-mediated interviews. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An overview of the Telecommunications Information NetworkingArchitecture

The Telecommunications Information Networking Architecture (TINA) Consortium is an international collaboration aiming at defining and validating an open architecture for telecommunication services for the broadband, multimedia, and information era. The architecture is based on distributed computing, object orientation, and other concepts and standards from the telecommunications and computing industries. This paper provides an introduction to TINA. First, it presents an overall view of TINA, followed by a brief introduction to the main parts of the architecture, namely the computing, network, service, and management architectures. This is followed by a brief overview of interworking and migration scenarios for legacy systems. Finally, an overview of a tool-set to aid service specification and design is presented     

Emotional intelligence in young and middle adulthood: Cross-sectional analysis of latent structure and means.

Differentiation of the construct of emotional intelligence was investigated in young and middle-aged adults, on the basis of hypotheses generated from differential emotions theory, discrete emotions functionalist theory, and empirical literature on age-related changes in affective complexity and differentiation of abilities. Both age groups were characterized by the same set of comparably related dimensions. However, midlife adults reported significantly greater use of optimism as a mood-regulation strategy than was reported by young adults. This study considers implications of possible structural continuity in emotional intelligence in conjunction with mean increases in the use of optimism as a strategy for managing affect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus

The VH4-21 (V4-34) gene segment, a member of the VH4 family, is expressed early in B-cell maturation and is utilized by approximately 6% of normal adult B lymphocytes. This prevalence indicates an importance of VH4-21 in the B-cell repertoire. The gene also encodes certain autoantibodies being mandatory for pathological IgM anti-red cell antibodies directed against the I/i antigen, and also capable of encoding anti-DNA antibodies. Recognition of I/i antigen or DNA appears to be via two distinct sites on VH, with I/i binding mediated by sequences in the framework region, and DNA binding correlating with the presence of positively charged amino acids in complementarity-determining region 3. However, these positively charged residues appear to suppress the ability of the framework region to interact with I/i, rendering a single sequence monospecific for I/i or DNA. The IgM anti-DNA antibodies also recognize bacterial lipid A, whereas the anti-I/i antibodies do not, indicating that CDR3 may be involved in binding the negatively charged lipid A. Structural similarities between the DNA backbone and lipid A provide a possible explanation for this cross-reactivity. This dual recognition of bacterial antigen and autoantigen provides a potential link between infection and autoimmunity.     

The Joint Evaluation Procedure for Active Substances contained in Plant Protection Products within the European Community – 10?Years of the ECCO-Project

Pflanzenschutzmittel müssen seit 1993 in den Mitgliedstaaten der Europ?ischen Gemeinschaft nach der Richtlinie 91/414/EWG des Rates bewertet und zugelassen werden. Das Programm zur Bewertung von alten Wirkstoffen (welche vor Juli 1993 auf dem Markt waren) beinhaltet mehrere Schritte und Stufen, die früher über einen Zeitraum von bis zu 10 Jahren zu bew?ltigen waren; heute sind dafür jedoch 15 Jahre vorgesehen. Das Programm wurde seit 1996 von der Europ?ischen Kommission mit Unterstützung des ECCO-Teams(European Community Co-Ordination) koordiniert. Das ECCO-Team bestand aus zwei Gruppen: eine im Pesticides Safety Directorate – PSD in York (Gro?britannien) und eine im Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL) bzw. vor November 2002 in der Biologischen Bundesanstalt für Land- und Forstwirtschaft in Braunschweig. Sie unterstüzten das Programm zur Bewertung von Wirkstoffen im Namen der Kommission in technischer und administrativer Hinsicht und zeichneten sich insbesondere für das ECCO Peer Review Programm (Expertenprüfungen) verantwortlich. Im November 2003 übernahm die Europ?ische Beh?rde für Lebensmittelsicherheit (EFSA) die Verantwortung für die wissenschaftliche überprüfung der von den Mitgliedstaaten erstellten Bewertungen durch Experten. Das ECCO-Team leistete jedoch weiterhin der Europ?ischen Kommission Unterstützung bei der Durchführung anderer Verfahrensaspekte, vor allem im Bereich der Managementaufgaben der Europ?ischen Kommission. Insgesamt war das Programm au?erordentlich erfolgreich. Es wurden für 162 Wirkstoffen zwischen 1996 und 2003 der Inhalt der von den Mitgliedstaaten erstellten Bewertungsberichte durch eine Expertengruppe diskutiert und füberprüft, was ma?geblich eine Entscheidungsfindung zur Akzeptabilitf?t dieser Wirkstoffe auf Gemeinschaftsebene erm?glicht hat.     

The changing face of emphysematous cholecystitis

Emphysematous cholecystitis is a variant of acute cholecystitis characterized by the presence of gas in the gall bladder lumen, wall or pericholecystic tissues in the absence of an abnormal communication between the biliary system and the gastrointestinal tract. In the past, the diagnosis has relied on the plain abdominal radiograph (AXR), since there are no clinical features to separate this condition from simple acute cholecystitis. The apparently high mortality and morbidity associated with emphysematous cholecystitis has previously emphasized the importance of emergency cholecystectomy. We have reviewed eight cases of emphysematous cholecystitis presenting to this hospital over the last 5 years. The diagnosis was made on AXR in only one of these cases. Ultrasound (US) scans were performed in all eight cases, of which five were positive and three negative, due to non-visualization of the gall bladder. In the three negative cases, the diagnosis was made on subsequent CT scans. On initial clinical examination, only one of the eight patients appeared systemically unwell and conservative management was employed in five of the patients. The remaining three patients underwent cholecystectomy within 3-5 days because of continuing signs or symptoms. It is concluded that the AXR is relatively insensitive in the diagnosis of emphysematous cholecystitis. As a result of the regular use of US in suspected hepatobiliary disease, emphysematous cholecystitis is being diagnosed with increased frequency, uncovering a broad spectrum of disease ranging from mild to severe. Previously, failure to separate milder cases from simple acute cholecystitis may have been responsible for reports of unremitting severity and progression requiring emergency cholecystectomy. Based on clinical assessment, conservative surgical management is possible in a significant proportion of patients.     

A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis

Germline mutations in the presenilin 1 (PS1) gene apparently account for the majority of early-onset, familial Alzheimer's disease (AD). Using a mutation-screening strategy (denaturing gradient gel electrophoresis; DGGE), we analyzed a large family with early onset AD and seizures. The patients in this family showed a novel missense mutation in exon 5 of the PS1 gene (A to T change in codon 120, altering glutamine to aspartic acid). This novel mutation is located within the second hydrophilic domain of the molecule, a region not particularly involved in previously described germline mutations, and is of unknown biological significance. These results also demonstrate that DGGE can be used effectively to screen for mutations within this gene.