Some approximate Godunov schemes to compute shallow-water equations with topography

We study here the computation of shallow-water equations with topography by Finite Volume methods, in a one-dimensional framework (though all methods introduced may be naturally extended in two dimensions). All methods are based on a discretisation of the topography by a piecewise function constant on each cell of the mesh, from an original idea of Le Roux et al. Whereas the Well-Balanced scheme of Le Roux is based on the exact resolution of each Riemann problem, we consider here approximate Riemann solvers. Several single step methods are derived from this formalism, and numerical results are compared to a fractional step method. Some test cases are presented: convergence towards steady states in subcritical and supercritical configurations, occurrence of dry area by a drain over a bump and occurrence of vacuum by a double rarefaction wave over a step. Numerical schemes, combined with an appropriate high-order extension, provide accurate and convergent approximations.     

Les déterminants individuels, interpersonnels et organisationnels de la détresse psychologique en milieu de travail.

Studied determinants of psychological stress in the workplace to test a 2-step model involving 3 organizational stressors (i.e., quantitative work overload, role conflict, and role ambiguity) and 3 types of resources (i.e., individual, interpersonal, and organizational). 636 full-time employees (mean age 37.5 yrs) of 4 organizations completed questionnaires assessing sociodemographic factors, organizational stressors, resources (i.e., locus of control, Type A (coronary prone) behavior, social support from supervisors and colleagues, and decisional latitude), and psychological stress. Interactions among these factors were determined via multiple regression analyses. Several French-language instruments were used, including the Questionnaire on Internal–External Locus of Control in the Workplace (N. Pettersen, 1984) and the Psychiatric Symptom Index (F. W. Ilfeld, 1976). (English abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Amyloid disease and extreme macroglossia. Apropos of a case

A case of extreme macroglossia was observed in a patient with amyloid disease and dysglobulinaemia. A medial diamond-shaped glossectomy was required to reduce the size of the tongue. The details of the surgical and anaesthetic procedure are presented. This type of surgery, greatly appreciated by the patient, can only be undertaken after careful preparation. The reported cases are rare and the indication for surgery is difficult due to the unpredictable nature of the local and general clinical course of the disease.     

Observing Inequality: Can Ergonomic Observations Help Interventions Transform the Role of Gender in Work Activity?

Computer Supported Cooperative Work (CSCW) - Work activity ergonomics (sometimes called francophone ergonomics) draws heavily on observation in order to support transformation of work to arrive at...     

Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons

Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan leading to a dysfunction of this transmembrane protein, alterations in the cerebello-thalamic pathway and impaired striatal plasticity. To elucidate underlying pathogenic mechanisms, we investigated induced pluripotent stem cell (iPSC)-derived striatal medium spiny neurons (MSNs) from two myoclonus-dystonia patients carrying a heterozygous mutation in the SGCE gene (c.298T>G and c.304C>T with protein changes W100G and R102X) in comparison to two matched healthy control lines. Calcium imaging showed significantly elevated basal intracellular Ca²⁺ content and lower frequency of spontaneous Ca²⁺ signals in SGCE MSNs. Blocking of voltage-gated Ca²⁺ channels by verapamil was less efficient in suppressing KCl-induced Ca²⁺ peaks of SGCE MSNs. Ca²⁺ amplitudes upon glycine and acetylcholine applications were increased in SGCE MSNs, but not after GABA or glutamate applications. Expression of voltage-gated Ca²⁺ channels and most ionotropic receptor subunits was not altered. SGCE MSNs showed significantly reduced GABAergic synaptic density. Whole-cell patch-clamp recordings displayed elevated amplitudes of miniature postsynaptic currents and action potentials in SGCE MSNs. Our data contribute to a better understanding of the pathophysiology and the development of novel therapeutic strategies for myoclonus-dystonia.     

Beam propagation constants for a radial laser array

The beam quality of a radial laser array, quantified in terms of the M(2) propagation constant, is determined as a function of array element configuration. A lower bound on array M(2) is estimated for both phase-locked and nonphase-locked conditions. It is shown that, to achieve near-unity M(2) array, either aperture filling or spatial filtering is required in addition to phase locking. An aperture-filling method suitable for radial arrays of CO(2) slab lasers is presented.     

Characterization of ozone sensors based on WO3 reactively sputtered films: influence of O2 concentration in the sputtering gas, and working temperature

We report on electrical responses of tungsten oxide thin film ozone sensors based on a tungsten trioxide (WO₃)/tin oxide (SiO₂)/Si structure with interdigitated Pt electrodes. The influence of O₂ concentration in the sputtering gas and working temperature of the sensor are investigated. Sensitivity to ozone increases with O₂ content in the sputtering gas. It reaches its highest value for sensors fabricated with 50% O₂. For these sensors, the best ozone sensitivity and shortest response and recovery times are obtained at a working temperature of 523 K. Ozone sensitivity is compared to other ozone sensors.