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排序方式: 共有254条查询结果,搜索用时 15 毫秒
1.
A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts
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2.
Effect of hydrogen charging on dislocation behavior in Ni-Cr and Ni<Subscript>2</Subscript>Cr alloys
Kaori Miyata 《Metallurgical and Materials Transactions A》2003,34(6):1249-1257
The effects of hydrogen charging on the dislocation behaviour in Ni-Cr binary alloys have been investigated by means of transmission
electron microscope (TEM) observations using single-crystalline specimens. The deformation mode of Ni-Cr alloys in the absence
of hydrogen is characterized by planar dislocations. However, hydrogen charging changed the dislocation configurations to
promote curved dislocations, such as dislocation loops and dipoles. The hydrogen-affected dislocation configurations are enhanced
with increasing Ni content and reducing Cr content. Weak-beam images show that the Shockley partials of the hydrogen-affected
dislocations frequently constrict to make kinks and cross-slip, as if the dislocations were generated by a thermally activated
process. The effect of hydrogen charging on superdislocations of a Ni2Cr superstructure has been also investigated using an aged 70Ni-30Cr alloy. While the deformation mode in the Ni2Cr superlattice is classified as five variants of superdislocation triplets and one variant of ordinary dislocations, the
hydrogen charging has preferred the ordinary dislocations to the superdislocation triplets. The results suggest that the charged
hydrogen changes the local plasticity to affect the deformation dynamics in Ni-Cr alloys, where the influence of hydrogen
on the plasticity is sensitive to the Ni/Cr concentration and the symmetry of atomic arrangement. 相似文献
3.
Characterization of C-S-H from Highly Reactive β-Dicalcium Silicate Prepared from Hillebrandite 总被引:1,自引:1,他引:0
Yoshihiko Okada Hideki Ishida Kaori Sasaki J. Francis Young Takeshi Mitsuda 《Journal of the American Ceramic Society》1994,77(5):1313-1318
β-dicalcium silicate synthesized by thermal dissociation of hydrothermally prepared hillebrandite (Ca2 (SiO3 )(OH)2 ) exhibits extremely high hydration activity. Characterization of the hydrates obtained and investigation of the hydration mechanism was carried out with the aid of trimethylsilylation analysis, 29 Si magic angle spinning nuclear magnetic resonance, transmission electron microscopy selected area electron diffraction, and XRD. The silicate anion structure of C-S-H consisted mainly of a dimer and a single-chain polymer. Polymerization advances with increasing curing temperature and curing time. The C-S-H has an oriented fibrous structure and exhibits a 0.73-nm dreierketten in the longitudinal direction. On heating, the C-S-H dissociates to form β-C2 S. The temperature at which βC2 S begins to form decreases with increasing chain length of the C-S-H or as the Ca/Si ratio becomes higher. The high activity of β-C2 S is due to its large specific surface area and the fact that the hydration is chemical-reaction-rate-controlled until its completion. As a result, the hydration progresses in situ and C-S-H with a high Ca/Si ratio is formed. 相似文献
4.
Compared 2 motivational bases for not contributing to a public good, desire to "free ride" (or greed) and fear of being a "sucker," among 110 Japanese undergraduates. It was hypothesized that these 2 types of motivation would be activated under different situations. When a public good was provided conjunctively, fear would have a strong effect but greed would not; when a public good was disjunctively provided, greed would have a strong effect but fear would not. In addition, it was predicted that the greater mutual trust existing among friends would make them contribute more than strangers would in the conjunctive condition but would make no difference in the disjunctive condition. Three types of production rules, in which a public good was conjunctively, disjunctively, or additively produced on the basis of members' contributions, were experimentally created. Half of the groups in each condition consisted of total strangers, and the other half consisted of friends. The hypotheses were supported when the size of the public good (bonus points) was relatively large. Also, Ss responded similarly in the conjunctive condition and in the additive condition. (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
Tetsuya Tanigami Nobuyuki Maruyama Koji Yamazaki Yoko Ichikawa Hiroyuki Nagai Kaori Shimizu 《应用聚合物科学杂志》2002,86(7):1807-1815
An almost fully saponified atactic poly(vinyl alcohol) and an atactic poly(vinyl alcohol‐block‐vinyl acetate) of which degree of saponification is 89 mol % were blended by a solution casting method. The phase structure of the blend film was analyzed by optical microscopy, 13C‐NMR, and differential scanning calorimetry. The most remarkable structure of the blend was composed of cylindrical domains penetrating the film. The swelling behavior of the blend films was also investigated in the dimethylsulfoxide and water mixed solvents to find differences in solubility and diffusion behavior between the matrix and the domain. The cylindrical domains could be selectively dissolved away in water and the film became porous. We tried to change the size of the cylindrical domain with various film preparation conditions. This aimed to turn the film into the useful filter membrane. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1807–1815, 2002 相似文献
6.
Hideki Ishida Kaori Sasaki Yoshihiko Okada Takeshi Mitsuda 《Journal of the American Ceramic Society》1992,75(9):2541-2546
The effect of curing temperature (40°, 60°, 80°C) on the hydration behavior of β-dicalcium silicate (β-C2 S) was investigated. The β-C2 S was obtained by decomposition of hillebrandite, Ca2 (SiO3 )(OH)2 , at 600°C, has a specific surface area of about 7 m2 /g, and is in the form of fibrous crystals. The dependence of the hydration reaction on temperature continues until the reaction is completed. The hydration is completed in 1 day at 80°C and in 14 days at 14°C. The hydration mechanism is different above and below 60°C, but at a given temperature, the reaction mechanism and the silicate anion structures of C-S-H do not change significantly from the initial to the late stages of the reaction. High curing temperature and long curing times after completion of reaction promote silicate polymerization. The Ca/Si ratio of C-S-H shows high values, being almost 2.0 above 60°C and 1.95 below 40°C. 相似文献
7.
A portable toolkit for supporting end-user personalization and control in context-aware applications 总被引:1,自引:0,他引:1
Fahim Kawsar Kaori Fujinami Tatsuo Nakajima Jong Hyuk Park Sang-Soo Yeo 《Multimedia Tools and Applications》2010,47(3):409-432
A context-aware application in the pervasive computing environment provides intuitive user centric services using implicit
context cues. Personalization and control are important issues for this class of application as they enable end-users to understand
and configure the behavior of an application. However most development efforts for building context-aware applications focus
on the sensor fusion and machine learning algorithms to generate and distribute context cues that drive the application with
little emphasis on user-centric issues. We argue that, to elevate user experiences with context-aware applications, it is
very important to address these personalization and control issues at the system interface level in parallel to context centric
design. Towards this direction, we present Persona, a toolkit that provides support for extending context-aware applications with end-user personalization and control features.
Specifically, Persona exposes a few application programming interfaces that abstract end-user customization and control mechanisms
and enables developers to integrate these user-centric aspects with rest of the application seamlessly. There are two primary
advantages of Persona. First, it can be used with various existing middlewares as a ready-to-use plug-in to build customizable
and controllable context-aware applications. Second, existing context-aware applications can easily be augmented to provide
end-user personalization and control support. In this paper, we discuss the design and implementation of Persona and demonstrate
its usefulness through the development and augmentation of a range of common context-aware applications. 相似文献
8.
Ichiro Takano Yoshiharu Arai Michiko Sasaki Yoshio Sawada Kaori Yamada Takayoshi Yagasaki Yuji Kimura 《Vacuum》2006,80(7):788-792
Biodegradable plastics can be used as conventional plastics, while on disposal they decompose to water and carbon dioxide by microorganisms existing in natural environment. Products using biodegradable plastics have recently been developed in many companies pursuing ecology. In this study, surface modification of biodegradable plastics was carried out by inert ion beams for improvement of photo deterioration under an ultraviolet ray. The hardness of biodegradable plastics tended generally to decrease with irradiation of an ultraviolet ray. In this method, the hardness of ion-bombarded biodegradable plastics was kept at an initial value under an ultraviolet ray, because the modified layer by ion bombardment intercepted an ultraviolet ray. The hardness of He+ ion-bombarded biodegradable plastics showed larger value than that of Ar+ ion bombardment. He+ ion bombardment at ion energy of 10 keV produced the suitable property with both of high transmittance of a visible ray and high interception of an ultraviolet ray in a surface layer of biodegradable plastics. 相似文献
9.
Oliver Shey-Njila Ahmed F. Hikal Tuhina Gupta Kaori Sakamoto Hind Yahyaoui Azami Wendy T. Watford Frederick D. Quinn Russell K. Karls 《International journal of molecular sciences》2022,23(10)
Copper is required for aerobic respiration by Mycobacterium tuberculosis and its human host, but this essential element is toxic in abundance. Copper nutritional immunity refers to host processes that modulate levels of free copper to alternately starve and intoxicate invading microbes. Bacteria engulfed by macrophages are initially contained within copper-limited phagosomes, which fuse with ATP7A vesicles that pump in toxic levels of copper. In this report, we examine how CtpB, a P-type ATPase in M. tuberculosis, aids in response to nutritional immunity. In vitro, the induced expression of ctpB in copper-replete medium inhibited mycobacterial growth, while deletion of the gene impaired growth only in copper-starved medium and within copper-limited host cells, suggesting a role for CtpB in copper acquisition or export to the copper-dependent respiration supercomplex. Unexpectedly, the absence of ctpB resulted in hypervirulence in the DBA/2 mouse infection model. As ctpB null strains exhibit diminished growth only in copper-starved conditions, reduced copper transport may have enabled the mutant to acquire a “Goldilocks” amount of the metal during transit through copper-intoxicating environments within this model system. This work reveals CtpB as a component of the M. tuberculosis toolkit to counter host nutritional immunity and underscores the importance of elucidating copper-uptake mechanisms in pathogenic mycobacteria. 相似文献
10.
Jia Shi Riku Kanoya Yurina Tani Sodai Ishikawa Rino Maeda Sana Suzuki Fumiya Kawanami Naoko Miyagawa Katsuhiko Takahashi Teruaki Oku Ami Yamamoto Kaori Fukuzawa Motowo Nakajima Tatsuro Irimura Nobuaki Higashi 《International journal of molecular sciences》2022,23(9)
We examined whether sulfated hyaluronan exerts inhibitory effects on enzymatic and biological actions of heparanase, a sole endo-beta-glucuronidase implicated in cancer malignancy and inflammation. Degradation of heparan sulfate by human and mouse heparanase was inhibited by sulfated hyaluronan. In particular, high-sulfated hyaluronan modified with approximately 2.5 sulfate groups per disaccharide unit effectively inhibited the enzymatic activity at a lower concentration than heparin. Human and mouse heparanase bound to immobilized sulfated hyaluronan. Invasion of heparanase-positive colon-26 cells and 4T1 cells under 3D culture conditions was significantly suppressed in the presence of high-sulfated hyaluronan. Heparanase-induced release of CCL2 from colon-26 cells was suppressed in the presence of sulfated hyaluronan via blocking of cell surface binding and subsequent intracellular NF-κB-dependent signaling. The inhibitory effect of sulfated hyaluronan is likely due to competitive binding to the heparanase molecule, which antagonizes the heparanase-substrate interaction. Fragment molecular orbital calculation revealed a strong binding of sulfated hyaluronan tetrasaccharide to the heparanase molecule based on electrostatic interactions, particularly characterized by interactions of (−1)- and (−2)-positioned sulfated sugar residues with basic amino acid residues composing the heparin-binding domain-1 of heparanase. These results propose a relevance for sulfated hyaluronan in the blocking of heparanase-mediated enzymatic and cellular actions. 相似文献