Experimental demonstration of all-optical regeneration using anMMI-SOA

A novel all-optical 2R regenerator based on a multimode interference coupler (MMI) semiconductor optical amplifier is presented. Static measurements of the transfer function reveal a digital transfer characteristic and a high increase in extinction ratio. The experiments are in good agreement with simulations, which have been done using a modified beam propagation method program. The device has a high tolerance to the MMI length. It has been fabricated in an all-active layout, avoiding the need for active/passive integration and is very compact     

African Americans and boys: Understanding the literacy gap, tracing academic trajectories, and evaluating the role of learning-related skills.

In this study, the authors examined the racial and gender gap in the academic development of African American and White children from kindergarten to 5th grade. Their main goal was to determine the extent to which social and behavioral factors, including learning-related skills, problem behaviors, and interpersonal skills, explain these gaps and shed light on the academic difficulties specifically experienced by African American boys. The authors utilized the Early Childhood Longitudinal Study–Kindergarten Cohort (ECLS-K) sample and applied growth curve modeling. Learning-related skills explained the literacy development of African American boys over and above the effects of problem behaviors, socioeconomic status, and home literacy environment. Results suggest that emphasis placed on the behavior problems and the social risk factors associated with African American boys needs to be refocused and should be accompanied by increased efforts to improve learning-related skills in the classroom context and beyond. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Life-cycle assessment and repair of the railway transition zones of an existing bridge using geocomposite materials

The railway infrastructure is a very important component of the world’s total transportation network. Investment in its construction and maintenance is therefore significant on a global scale. Up to now, some results of the life-cycle assessment (LCA) of open railway line, as well as railway bridges and tunnels, have been published, but detailed analyses of transition zones have not so far been performed. In railway networks, transitional zones are a critical area where the transition from open rail to solid bridge construction can cause significant settlements. The goal of these analyses was to compare two different types of track renewal methods for railway transition zones. In the first method, traditional cement stabilisation is used, whereas the second solution makes use of a geocomposite anchored by steel anchors. The paper presents some results from an environmental study for railway transition zones based on the demonstration case. The results of the performed LCA showed that, in the case of track renewal for transition zones by means of a geocomposite and anchors, the environmental impact is lower than in the case when cement stabilisation works are performed. Less extensive excavation works and thus lower quantities of used material are additional benefits.     

Cobalt Ferrite Magnetic Nanoparticles for Tracing Mesenchymal Stem Cells in Tissue: A Preliminary Study

Therapy with mesenchymal stem cells (MSCs) is promising in many diseases. Evaluation of their efficacy depends on adequate follow-up of MSCs after transplantation. Several studies have shown that MSCs can be labeled and subsequently visualized with magnetic nanoparticles (NPs). We investigated the homing of MSCs labeled with magnetic cobalt ferrite NPs in experimentally induced acute kidney injury in mice. To explore the homing of MSCs after systemic infusion into mice, we developed a pre-infusion strategy for optimal tracing and identification of MSCs with polyacrylic acid-coated cobalt ferrite (CoFe₂O₄) NPs by light and transmission electron microscopy (TEM) in various organs of mice with cisplatin-induced acute kidney injury and control mice. By correlative microscopy, we detected MSCs labeled with NPs in the lungs, spleen, kidney, and intestine of cisplatin-treated mice and in the lungs and spleen of control mice. Our results confirm that labeling MSCs with metal NPs did not affect the ultrastructure of MSCs and their ability to settle in various organs. This study demonstrates the usefulness of cobalt ferrite NPs in ex vivo visualization of MSCs and offers correlative microscopy as a useful method in routine histopathology laboratories for tracing MSCs in paraffin-embedded tissue.     

The MAOA rs979605 Genetic Polymorphism Is Differentially Associated with Clinical Improvement Following Antidepressant Treatment between Male and Female Depressed Patients

Major depressive disorder (MDD) is the leading cause of disability worldwide. Treatment with antidepressant drugs (ATD), which target monoamine neurotransmitters including serotonin (5HT), are only modestly effective. Monoamine oxidase (MAO) metabolizes 5HT to 5-hydroxy indoleacetic acid (5HIAA). Genetic variants in the X-chromosome-linked MAO-encoding genes, MAOA and MAOB, have been associated with clinical improvement following ATD treatment in depressed patients. Our aim was to analyze the association of MAOA and MAOB genetic variants with (1) clinical improvement and (2) the plasma 5HIAA/5HT ratio in 6-month ATD-treated depressed individuals. Clinical (n = 378) and metabolite (n = 148) data were obtained at baseline and up to 6 months after beginning ATD treatment (M6) in patients of METADAP. Mixed-effects models were used to assess the association of variants with the Hamilton Depression Rating Scale (HDRS) score, response and remission rates, and the plasma 5HIAA/5HT ratio. Variant × sex interactions and dominance terms were included to control for X-chromosome-linked factors. The MAOA rs979605 and MAOB rs1799836 polymorphisms were analyzed. The sex × rs979605 interaction was significantly associated with the HDRS score (p = 0.012). At M6, A allele-carrying males had a lower HDRS score (n = 24, 10.9 ± 1.61) compared to AA homozygous females (n = 14, 18.1 ± 1.87; p = 0.0067). The rs1799836 polymorphism was significantly associated with the plasma 5HIAA/5HT ratio (p = 0.018). Overall, CC/C females/males had a lower ratio (n = 44, 2.18 ± 0.28) compared to TT/T females/males (n = 60, 2.79 ± 0.27; p = 0.047). The MAOA rs979605 polymorphism, associated with the HDRS score in a sex-dependent manner, could be a useful biomarker for the response to ATD treatment.     

Realization of a Four-Electrode Liquid Crystal Device With Full In-Plane Director Rotation

A liquid crystal device with micrometer-scale hexagonal electrodes has been fabricated and characterized. By using weak anchoring at the liquid crystal interfaces, the orientation of the director is completely governed by the applied electric fields. The appropriate voltage waveforms applied to electrodes allow the director in the liquid crystal layer to be rotated in the plane parallel to the substrates over large angles, exceeding 180 deg. This paper is a technological and experimental verification of an earlier proposed device concept     

Architecting play

From the grotesque pavilions hidden in sixteenth century Italian gardens to the temporary structures in public space in the 70s and recent digitally augmented environments, architectures of play have long been designed to engage explorative experiences. The uncertainty of play allows us to probe new behaviors, to poke into the boundaries of subjectivity and to interact with people, things and systems in unexpected and unfamiliar ways. In this essay, we explore how an interactive system, situated in public space, may foster explorative activities and enable the transformative power of play. Through the analysis of several computer-augmented architectures, we examine what interactive qualities might enhance the transformative power of play. Beginning with the Fun Palace, an early attempt to use cybernetics in order to encourage visitors to experiment with their habits, we move to contemporary projects including some of the author’s own work. The latter takes the advantage of existing public locations in order to insert exploratory play into everyday life. Through analysis of these projects, we discuss whether such environments raise our responsibility toward others within our surroundings; whether they enable us to transform our own established behaviors; and whether they empower us to reclaim public space.     

Monolithically integrated multi-wavelength laser by selective areagrowth with metal organic vapour phase epitaxy

A multiwavelength laser (MWL) is fabricated by means of selective area growth (SAG) with metal organic vapour phase epitaxy (MOVPE). The MWL consists of an array of amplifiers monolithically integrated with a transmissive (de-)multiplexer and to the author' knowledge, is the first device of the kind realised with only two growth step making use of SAG MOVPE     

Life cycle assessment of a geosynthetic-reinforced soil bridge system – A case study

Road infrastructures are a very important component of the world's total transportation network. Investment in its construction and maintenance is significant on a global scale. The paper presents some results from an environmental study of a geosynthetic-reinforced soil integrated bridge system. The Pavlovski potok stream in Slovenia was used as a demonstration case for this study. It is the first GRS bridge system with full-height rigid (FHR) facings in Europe. It was constructed at the end of 2014. The goal of these analyses was to compare two different types of bridges: the new GRS bridge system, which is comprised of a simple girder partially structurally integrated to FHR facings of GRS bridge abutments and a conventional reinforced concrete road bridge. The results of an environmental life cycle assessment (LCA) show that the GRS bridge system has a much lower environmental impact than an equivalent bridge conventionally built with reinforced concrete.