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1.
This paper presents an approach to assist authors during the authoring of multimedia presentations. We extend the existing authoring support by integrating processes of topic identification, content collection and discourse structure building in a single environment. This integration allows identification of the context of the authoring process. Our approach combines this process context awareness with explicit domain and discourse knowledge to steer system suggestions. We evaluate our approach with an experimental system prototype. 相似文献
2.
We analyze specific features of the design of equipment used for mechanical testing of sheet structural materials under the conditions of biaxial static, cyclic, or dynamic loading. We propose original solutions of the problems related to the fatigue testing of crosslike specimens performed without using complex hydraulic systems and their dynamic testing carried out by using very simple testing machines for uniaxial tension–compression. 相似文献
3.
Simonetta Pazzaglia Barbara Tanno Francesca Antonelli Paola Giardullo Gabriele Babini Prabal Subedi Omid Azimzadeh Zohaib N. Khan Kateryna Oleksenko Fabian Metzger Christine von Toerne Damien Traynor Dinesh Medipally Aidan D. Meade Munira Kadhim Fiona M. Lyng Soile Tapio Anna Saran Mariateresa Mancuso 《International journal of molecular sciences》2021,22(8)
The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test the potential contribution of non-targeted effects in the detrimental response of the hippocampus to irradiation and to elucidate the mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial body (PBI) irradiated with 0.1 or 2.0 Gy of X-rays or sham irradiated. PBI consisted of the exposure of the lower third of the mouse body, whilst the upper two thirds were shielded. Hippocampi were collected 15 days or 6 months post-irradiation and a multi-omics approach was adopted to assess the molecular changes in non-coding RNAs, proteins and metabolic levels, as well as histological changes in the rate of hippocampal neurogenesis. Notably, at 2.0 Gy the pattern of early molecular and histopathological changes induced in the hippocampus at 15 days following PBI were similar in quality and quantity to the effects induced by WBI, thus providing a proof of principle of the existence of out-of-target radiation response in the hippocampus of conventional mice. We detected major alterations in DAG/IP3 and TGF-β signaling pathways as well as in the expression of proteins involved in the regulation of long-term neuronal synaptic plasticity and synapse organization, coupled with defects in neural stem cells self-renewal in the hippocampal dentate gyrus. However, compared to the persistence of the WBI effects, most of the PBI effects were only transient and tended to decrease at 6 months post-irradiation, indicating important mechanistic difference. On the contrary, at low dose we identified a progressive accumulation of molecular defects that tended to manifest at later post-irradiation times. These data, indicating that both targeted and non-targeted radiation effects might contribute to the pathogenesis of hippocampal radiation-damage, have general implications for human health. 相似文献
4.
Alexander Zimmermann Qais Z. Jaber Dr. Johannes Koch Steffen Riebe Dr. Cecilia Vallet Dr. Kateryna Loza Matthias Hayduk Dr. Kfir B. Steinbuch Prof. Shirley K. Knauer Prof. Micha Fridman Jun.-Prof. Jens Voskuhl 《Chembiochem : a European journal of chemical biology》2021,22(9):1563-1567
We report the characterization of amphiphilic aminoglycoside conjugates containing luminophores with aggregation-induced emission properties as transfection reagents. These inherently luminescent transfection vectors are capable of binding plasmid DNA through electrostatic interactions; this binding results in an emission “on” signal due to restriction of intramolecular motion of the luminophore core. The luminescent cationic amphiphiles effectively transferred plasmid DNA into mammalian cells (HeLa, HEK 293T), as proven by expression of a red fluorescent protein marker. The morphologies of the aggregates were investigated by microscopy as well as ζ-potential and dynamic light-scattering measurements. The transfection efficiencies using luminescent cationic amphiphiles were similar to that of the gold-standard transfection reagent Lipofectamine® 2000. 相似文献
5.
Kateryna Vyshnyakova Gleb Yushin Ludmila Pereselentseva Yury Gogotsi 《International Journal of Applied Ceramic Technology》2006,3(6):485-490
Biomorphous β-SiC ceramics were produced at 1400°C from pine wood impregnated with silica. This one-step carbothermal reduction process decreases the cost of manufacturing of SiC ceramics compared with siliconization of carbonized wood in silicon vapor. The synthesized sample exhibits a 14 m2 /g surface area and has a hybrid pore structure with large 5–20 μm tubular macropores and small (<50 nm) slit-shaped mesopores. SiC whiskers of 20–400 nm in diameter and 5–20 μm in length formed within the tubular pores. These whiskers are expected to improve the filtration by removing dust particles that could otherwise penetrate through large pores. After ultrasonic milling, the powdered sample showed an average particle size of ∼30 nm. The SiC nanopowder produced in this process may be used for manufacturing SiC ceramics for structural, tribological, and other applications. 相似文献
6.
Stepan Kudria Iryna Ivanchenko Borys Tuchynskyi Kateryna Petrenko Oleksii Karmazin Oleksandr Riepkin 《International Journal of Hydrogen Energy》2021,46(1):157-168
The paper provides an assessment of the current wind energy potential in Ukraine, and discusses developmental prospects for wind-hydrogen power generation in the country. Hydrogen utilization is a highly promising option for Ukraine's energy system, environment, and business. In Ukraine, an optimal way towards clean zero-carbon energy production is through the development of the wind-hydrogen sector. In order to make it possible, the energy potential of industrial hydrogen production and use has to be studied thoroughly.Ukraine possesses huge resources for wind energy supply. At the beginning of 2020, the total installed capacity of Ukrainian wind farms was 1.17 GW. Wind power generation in Ukraine has significant advantages in comparison to the use of traditional sources such as thermal and nuclear energy.In this work, an assessment of the wind resource potential in Ukraine is made via the geographical approach suggested by the authors, and according to the «Methodical guidelines for the assessment of average annual power generation by a wind turbine based on the long-term wind speed observation data». The paper analyses the long-term dynamics of average annual wind speed at 40 Ukrainian weather stations that provide valid data. The parameter for the vertical wind profile model is calculated based on the data reanalysis for 10 m and 50 m altitudes. The capacity factor (CF) for modern wind turbine generators is determined. The CF spatial distribution for an average 3 MW wind turbine and the power generation potential for the wind power plants across the territory of Ukraine are mapped.Based on the wind energy potential assessment, the equivalent possible production of water electrolysis-derived green hydrogen is estimated. The potential average annual production of green hydrogen across the territory of Ukraine is mapped.It is concluded that Ukraine can potentially establish wind power plants with a total capacity of 688 GW on its territory. The average annual electricity production of this system is supposed to reach up to 2174 bln kWh. Thus, it can provide an average annual production of 483 billion Nm3 (43 million tons) of green hydrogen by electrolysis. The social efficiency of investments in wind-hydrogen electricity is presented. 相似文献
7.
The ice surface softening by friction is investigated considering the additive non-correlated fluctuations of the shear strain and stress, and the temperature. The premelting is construed by the Kelvin–Voigt equation for shear strain and by the relaxation equations of Landau–Khalatnikov type for shear stress and temperature. Taking into account the noises in these equations, the Langevin and Fokker–Planck equations are derived. Their analysis is based on the investigation of extrema of the distribution function, i.e., steady-state values of the shear strain using the Stratonovich interpretation. The phase diagrams are constructed, where the noises intensities and thermostat temperature determine the regions of ice, softened ice and their mixture (stick–slip rubbing). We present that domain of ice friction is bounded by relatively small background sliding block temperatures and fluctuation intensities of the stress and temperature. The ice film softens with growth of the stress noise intensity even at small thermostat temperatures. The friction force time series for all rubbing modes are calculated and compared with experimentally observed ones. 相似文献
8.
9.
Plasma polymerized γ‐terpinene (pp?GT) thin films are fabricated using RF plasma polymerization. MIM structures are fabricated and using the capacitive structures dielectric properties of the material is studied. The dielectric constant values are found to be in good agreement with those determined from ellipsometric data. At a frequency of 100 kHz, the dielectric constant varies with RF deposition power, from 3.69 (10 W) to 3.24 (75 W). The current density–voltage (J?V) characteristics of pp–GT thin films are investigated as a function of RF deposition power at room temperature to determine the resistivity and DC conduction mechanism of the films. At higher applied voltage region, Schottky conduction is the dominant DC conduction mechanism. The capacitance and the loss tangent are found to be frequency dependent. The conductivity of the pp?GT thin films is found to decrease from 1.39 × 10?12 S/cm (10 W) to 1.02 × 10?13 S/cm (75 W) and attributed to the change in the chemical composition and structure of the polymer. The breakdown field for pp–GT thin films increases from 1.48 MV/cm (10 W) to 2 MV/cm (75 W). A single broad relaxation peak is observed indicating the contribution of multiple relaxations to the dielectric response for temperature dependent J?V. The distribution of these relaxation times is determined through regularization methods. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42318. 相似文献
10.
Olena V. Moshynets Taras P. Baranovskyi Olga S. Iungin Nadiia P. Kysil Larysa O. Metelytsia Ianina Pokholenko Viktoria V. Potochilova Geert Potters Kateryna L. Rudnieva Svitlana Y. Rymar Ivan V. Semenyuta Andrew J. Spiers Oksana P. Tarasyuk Sergiy P. Rogalsky 《International journal of molecular sciences》2022,23(2)
The choice of effective biocides used for routine hospital practice should consider the role of disinfectants in the maintenance and development of local resistome and how they might affect antibiotic resistance gene transfer within the hospital microbial population. Currently, there is little understanding of how different biocides contribute to eDNA release that may contribute to gene transfer and subsequent environmental retention. Here, we investigated how different biocides affect the release of eDNA from mature biofilms of two opportunistic model strains Pseudomonas aeruginosa ATCC 27853 (PA) and Staphylococcus aureus ATCC 25923 (SA) and contribute to the hospital resistome in the form of surface and water contaminants and dust particles. The effect of four groups of biocides, alcohols, hydrogen peroxide, quaternary ammonium compounds, and the polymeric biocide polyhexamethylene guanidine hydrochloride (PHMG-Cl), was evaluated using PA and SA biofilms. Most biocides, except for PHMG-Cl and 70% ethanol, caused substantial eDNA release, and PHMG-Cl was found to block biofilm development when used at concentrations of 0.5% and 0.1%. This might be associated with the formation of DNA–PHMG-Cl complexes as PHMG-Cl is predicted to bind to AT base pairs by molecular docking assays. PHMG-Cl was found to bind high-molecular DNA and plasmid DNA and continued to inactivate DNA on surfaces even after 4 weeks. PHMG-Cl also effectively inactivated biofilm-associated antibiotic resistance gene eDNA released by a pan-drug-resistant Klebsiella strain, which demonstrates the potential of a polymeric biocide as a new surface-active agent to combat the spread of antibiotic resistance in hospital settings. 相似文献