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1.
Young's modulus of porous brittle solids 总被引:2,自引:0,他引:2
A new equationE =E
0 (1 –aP)
n
whereE andE
0 are the Young's moduli at porosity,P, and zero, respectively, a andn are material constants, has been derived semi-empirically for describing the porosity dependence of Young's modulus of brittle solids. The equation satisfies quite well the exact theoretical solution for the values of Young's moduli at different porosities for model systems with ideal and non-ideal packing geometry. The equation shows excellent agreement with the data On- and-alumina over a wide range of porosity. Unlike the existing porosity-elastic modulus equations, the proposed equation satisfies the boundary conditions and is inherently capable of treating isometric closed pores as well as non-isometric interconnected pores. The parameters a and n provide information about the packing geometry and pore structure of the material. 相似文献
2.
The effect of sonication on proteolytic hydrolysis of ovotransferrin and bioactivities of the hydrolysates were investigated, and the large peptide fragments left in the hydrolysate were characterised. The results showed that sonication could increase the reactive sulphydryl groups in 5% ovotransferrin solution by 50%, although there were no improvements in the overall degree of hydrolysis. Furthermore, SDS–PAGE and reverse-phase HPLC profiles did not show difference of the treated samples. Angiotensin-converting enzyme (ACE) inhibitory activity, but not antioxidant activity, of the thermolysin hydrolysate was improved in a dose dependent manner at prolonged sonication time. Matrix assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF/MS) analysis revealed that thermolysin hydrolysate was composed of 926 peptides, of 99% having masses lower than 10 kDa and of 1% larger than 10 kDa derived from both N- and C-lobes of ovotransferrin. 相似文献
3.
Nandagopal Krishnadas; Tadaki Douglas K.; Lamerdin John A.; Serpersu Engin H.; Niyogi Salil K. 《Protein engineering, design & selection : PEDS》1996,9(9):781-788
The biological importance of Leu15 of epidermal growth factor(EGF) is suggested by its conservation through evolution, itscritical location in the domaindomain interface of EGFand its close proximity to Arg41, a residue that is crucialfor receptor binding and activation. Mutagenesis of Leu15 ofhuman EGF (hEGF) was employed to examine the role of this residuein the ligand-receptor interaction. The relative receptor affinitiesof the hEGF variants, as determined by radioreceptor competitionassays, varied depending on the amino acid substitution. TheL15F, L15W and L15V hEGF analogues had receptor affinities 45,26 and 18% respectively of wild type hEGF. The L15A and L15Ranalogues displayed receptor affinities of only 2.4 and 1.6%relative to wild type hEGF. No binding of the L15E analoguewas detected. The relative agonist activities, as measured byreceptor tyrosine kinase stimulation assays, generally followeda similar trend. The L15F, L15W and L15V analogues stimulatedthe receptor kinase to a level (Vmax) similar to that for wildtype hEGF. A striking difference was observed between the L15Aand L15R variants; although having similar binding affinities,the L15A mutant activated the receptor to only {small tilde}5%of the wild type Vmax in contrast to 53% for the L15R mutant1H-NMR analysis of the L15R and L15A mutants showed only minorstructural alterations that were not sufficient to account forthe dramatic losses in binding and agonist activities. The resultsindicate that both the size and hydrophobicity of the -branchedaliphatic side chain of Leu15 of hEGF are important in the formationof a catalytically active ligandreceptor complex. 相似文献
4.
N. K. Pramanik R. S. Haldar Y. K. Bhardwaj S. Sabharwal U. K. Niyogi R. K. Khandal 《应用聚合物科学杂志》2011,122(1):193-202
Nylon 66 has been transformed into a material with significantly improved properties like hardness, tensile strength, and flexural modulus by processing it under the optimized dose rate of electron beam in the presence of suitable crosslinkers. Furthermore, percent water absorption of nylon 66 was reduced substantially on irradiation. Thermogravimetric analysis revealed that thermal stability of nylon 66 improved with increasing dose of radiation. Improvement of mechanical and thermal properties and reduction of water absorption of nylon 66 were due to the crosslinking of polyamide molecules made possible by the high energy radiation. Increase of crosslinking with increasing radiation dose was verified by the increase of gel content at higher doses. Differential scanning calorimetry showed that both melting and crystallization temperatures along with percent crystallinity of nylon 66 were decreased with the increasing dose of radiation leading to the development of more amorphous character in this semicrystalline polymer. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011. 相似文献
5.
BJ Pogson KK Niyogi O Bj?rkman D DellaPenna 《Canadian Metallurgical Quarterly》1998,95(22):13324-13329
Collectively, the xanthophyll class of carotenoids perform a variety of critical roles in light harvesting antenna assembly and function. The xanthophyll composition of higher plant photosystems (lutein, violaxanthin, and neoxanthin) is remarkably conserved, suggesting important functional roles for each. We have taken a molecular genetic approach in Arabidopsis toward defining the respective roles of individual xanthophylls in vivo by using a series of mutant lines that selectively eliminate and substitute a range of xanthophylls. The mutations, lut1 and lut2 (lut = lutein deficient), disrupt lutein biosynthesis. In lut2, lutein is replaced mainly by a stoichiometric increase in violaxanthin and antheraxanthin. A third mutant, aba1, accumulates normal levels of lutein and substitutes zeaxanthin for violaxanthin and neoxanthin. The lut2aba1 double mutant completely lacks lutein, violaxanthin, and neoxanthin and instead accumulates zeaxanthin. All mutants were viable in soil and had chlorophyll a/b ratios ranging from 2.9 to 3.5 and near wild-type rates of photosynthesis. However, mutants accumulating zeaxanthin exhibited a delayed greening virescent phenotype, which was most severe and often lethal when zeaxanthin was the only xanthophyll present. Chlorophyll fluorescence quenching kinetics indicated that both zeaxanthin and lutein contribute to nonphotochemical quenching; specifically, lutein contributes, directly or indirectly, to the rapid rise of nonphotochemical quenching. The results suggest that the normal complement of xanthophylls, while not essential, is required for optimal assembly and function of the light harvesting antenna in higher plants. 相似文献
6.
Debabrata Rautaray Kaustav Sinha Sudhakar R. Sainkar Renu Pasricha Neela R. Pavaskar Murali Sastry 《Journal of the American Ceramic Society》2005,88(1):24-27
This paper describes the growth of barium chromate (BaCrO4 ) nanocrystallites within thermally evaporated thin films of stearic acid (StA) and sodium bis-2-ethylhexyl-sulfosuccinate by a process of Ba2+ ion entrapment followed by in situ reaction with CrO4 2− ions. Dense spherical assemblies of BaCrO4 nanocrystallites of very uniform size (∼50 nm) were obtained within the two different host matrices. The spherical assemblies were composed of smaller (ca. 5–10 nm size) BaCrO4 crystals indicating that efficient size control over crystal size may be exercised by the matrix. Contact angle measurements of the BaCrO4 –StA and BaCrO4 –sodium bis-2-ethylhexyl-sulfosuccinate films indicated that they were hydrophobic, thus pointing to the possible role of hydrophobic interaction between the StA and sodium bis-2-ethylhexyl-sulfosuccinate monolayer-covered BaCrO4 crystals in the assembly process. 相似文献
7.
Niyogi P. Girosi F. Poggio T. 《Proceedings of the IEEE. Institute of Electrical and Electronics Engineers》1998,86(11):2196-2209
One of the key problems in supervised learning is the insufficient size of the training set. The natural way for an intelligent learner to counter this problem and successfully generalize is to exploit prior information that may be available about the domain or that can be learned from prototypical examples. We discuss the notion of using prior knowledge by creating virtual examples and thereby expanding the effective training-set size. We show that in some contexts this idea is mathematically equivalent to incorporating the prior knowledge as a regularizer, suggesting that the strategy is well motivated. The process of creating virtual examples in real-world pattern recognition tasks is highly nontrivial. We provide demonstrative examples from object recognition and speech recognition to illustrate the idea 相似文献
8.
A conserved regulatory mechanism protects plants against the potentially damaging effects of excessive light. Nearly all photosynthetic eukaryotes are able to dissipate excess absorbed light energy in a process that involves xanthophyll pigments. To dissect the role of xanthophylls in photoprotective energy dissipation in vivo, we isolated Arabidopsis xanthophyll cycle mutants by screening for altered nonphotochemical quenching of chlorophyll fluorescence. The npq1 mutants are unable to convert violaxanthin to zeaxanthin in excessive light, whereas the npq2 mutants accumulate zeaxanthin constitutively. The npq2 mutants are new alleles of aba1, the zeaxanthin epoxidase gene. The high levels of zeaxanthin in npq2 affected the kinetics of induction and relaxation but not the extent of nonphotochemical quenching. Genetic mapping, DNA sequencing, and complementation of npq1 demonstrated that this mutation affects the structural gene encoding violaxanthin deepoxidase. The npq1 mutant exhibited greatly reduced nonphotochemical quenching, demonstrating that violaxanthin deepoxidation is required for the bulk of rapidly reversible nonphotochemical quenching in Arabidopsis. Altered regulation of photosynthetic energy conversion in npq1 was associated with increased sensitivity to photoinhibition. These results, in conjunction with the analysis of npq mutants of Chlamydomonas, suggest that the role of the xanthophyll cycle in nonphotochemical quenching has been conserved, although different photosynthetic eukaryotes rely on the xanthophyll cycle to different extents for the dissipation of excess absorbed light energy. 相似文献
9.
CC Reddy SK Niyogi A Wells HS Wiley DA Lauffenburger 《Canadian Metallurgical Quarterly》1996,14(13):1696-1699
Successful use of growth factors in therapeutic and bioprocessing applications requires overcoming two attenuation mechanisms: growth factor depletion and receptor down-regulation. Current ameliorative strategies use physiologically inappropriate high growth-factor concentrations, along with periodic media refeeding in vitro and reinjection or controlled-release devices in vivo. We demonstrate a new approach derived from understanding how these attenuation mechanisms arise from ligand/receptor trafficking processes. Specifically, a recombinant epidermal growth factor (EGF) mutant with reduced receptor binding affinity is a more potent mitogenic stimulus for fibroblasts than natural EGF or transforming growth factor alpha because of its altered trafficking properties. 相似文献
10.
The paper describes an experimental program designed to investigate the effect of age at time of loading on basic and drying concrete creep. The data indicate that both components of creep are significantly affected by age; drying creep as a decreasing function of age, while basic creep initially increases with age and then decreases. Functional relationships for both basic creep and drying creep are derived and compared to the experimental results. 相似文献