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排序方式: 共有97条查询结果,搜索用时 0 毫秒
1.
Atharva Kale Natasha M. Rogers Kedar Ghimire 《International journal of molecular sciences》2021,22(8)
Recent advances provide evidence that the cellular signalling pathway comprising the ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range of diseases affecting renal, vascular, and metabolic function, as well as cancer. In several instances, research has barely progressed past pre-clinical animal models of disease and early phase 1 clinical trials, while for cancers, anti-CD47 therapy has emerged from phase 2 clinical trials in humans as a crucial adjuvant therapeutic agent. This has important implications for interventions that seek to capitalize on targeting this pathway in diseases where TSP1 and/or CD47 play a role. Despite substantial progress made in our understanding of this pathway in malignant and cardiovascular disease, knowledge and translational gaps remain regarding the role of this pathway in kidney and metabolic diseases, limiting identification of putative drug targets and development of effective treatments. This review considers recent advances reported in the field of TSP1-CD47 signalling, focusing on several aspects including enzymatic production, receptor function, interacting partners, localization of signalling, matrix-cellular and cell-to-cell cross talk. The potential impact that these newly described mechanisms have on health, with a particular focus on renal and metabolic disease, is also discussed. 相似文献
2.
3.
An algebraic turbulent eddy viscosity model is proposed based on a length scale model coupled with the turbulent viscosity expression of the renormalization group theory of turbulence. The eddy viscosity is presented as a solution of a quartic equation. The new length scale model is based on boundary layer characteristics (displacement thickness, shape factor). The model is applied to transitional boundary layer flow over a flat plate and to flow in a smooth pipe. Predictions for the laminar-turbulent transition, and integral characteristics, such as the total skin friction coefficient, mean velocity profile across the boundary layer, and the friction coefficient in a pipe, are found to be in good agreement with experimental data. 相似文献
4.
Anil Kumar Mandeep Kaur Rajeev Kumar Pinaki Ranjan Sengupta Vasantha Raman Gopal Bhatia Kedar Nath Sood 《Journal of Materials Science》2010,45(5):1393-1400
Carbon–copper composites with varying copper to carbon ratio of 0.66–1.5 (by weight) were developed from coal-tar-pitch-derived
green coke (as such or modified with natural graphite) as carbon source and electrolytic grade copper powder at different
heat treatment temperatures (HTTs) of 1000–1400 °C. The physical, mechanical, and electrical properties differ depending upon
the HTT and also on copper to carbon ratio (Cu/C). The composites prepared at HTT of 1100 °C having Cu/C ratio of 0.66 and
0.9 exhibited a high bending strength of 150 and 140 MPa, bulk density of 2.63 and 2.81 gm/cm3, electrical resistivity of 1.6 and 0.96 m Ω cm and shore hardness of 88 and 84, respectively, in spite of well-known inadequate
wettability between copper and carbon. Increasing the temperature from 1100 °C for processing of the composites deteriorated
the properties mainly due to the loss of copper through melting above 1100 °C as revealed by X-ray, scanning electron microscopy,
thermal analysis and EDAX studies. 相似文献
5.
Zeron Y Ocheretny A Kedar O Borochov A Sklan D Arav A 《Reproduction (Cambridge, England)》2001,121(3):447-454
Follicle dynamics and oocyte viability in Holstein primiparous and multiparous cows and the relationships between fertility and the biochemical and physical properties of oocyte membranes with season were examined. The conception rates of primiparous (n = 70 885) and multiparous (n = 143 490) cows differed, peaking in the winter and decreasing in the summer. The number of follicles 3-8 mm in diameter per ovary was higher in winter (19.6) compared with summer (12.0). However, in winter the percentage of ovaries with fewer than ten follicles per ovary was 16%, in contrast to 50% in summer. After aspiration of follicles, 7.5 oocytes per ovary were found in winter and 5.0 oocytes per ovary in summer. Cleavage to the two- to four-cell stage after chemical activation was greater in winter than in summer; this was enhanced at the morula stage and embryo development to the blastocyst stage was significantly higher in winter than in summer. Determination of the lipid phase transition in oocyte membranes revealed a shift of 6 degrees C between summer and winter. Fatty acid composition of phospholipids from follicular fluid, granulosa cells and oocytes indicated that there was a higher percentage of saturated fatty acids during the summer and that the percentages of mono-unsaturated and polyunsaturated fatty acids were higher in oocytes and granulosa cells during the winter. Oocytes and granulosa cells had similar fatty acid compositions, in contrast to follicular fluid. These results may explain the differences in the ability of oocytes to develop to the blastocyst stage at different seasons. Thus, temperature changes may lead to changes in membrane properties, which, in turn, can influence oocyte function and fertility. 相似文献
6.
Dielectric nanoflakes of Sb2Te3 represent an important advance in science and technology due to their extraordinary properties. Polycrystalline layered Sb2Te3 nanoflakes have been successfully synthesized via a high-throughput chemical route at 60°C. The frequency and temperature dependence of the dielectric constant and dielectric loss of the layered Sb2Te3 nanoflakes have been measured in the frequency range from 30 Hz to 758,000 Hz and temperature range from 313 K to 373 K. As-synthesized Sb2Te3 nanoflakes are shown to be promising alternative dielectrics because of their high dielectric constant (ε′ ≈ 7.3 to 6022) and low dielectric loss (tan δ ≈ 0.2 to 9.2). These higher values of ε′ and lower values of tan δ of Sb2Te3 nanoflakes confirm that capacitors with capacity (C) of ~5.2 pF to 4336 pF may be fabricated for storing renewable energy. Raman spectroscopy confirms that the peak located at ~142 cm?1 corresponds to one in-plane vibrational mode (E g 2 ) of layered Te–Sb–Te–Sb–Te lattice vibration. 相似文献
7.
Kedar Prasad Singh 《Chemical Engineering Communications》2003,190(11):1441-1448
The effect of reaction time in aerial oxidation of Assam coal on variation in moisture with wt% solubility in ethanolamine is presented. The effects of variation in helium density, specific energy, carboxyl acidity, and acid equivalent values on wt% solubilities of oxidized coal in ethanolamine are also highlighted. It is observed that progressive increase of oxidation time caused an increase in the moisture content and wt% solubility of oxidized coal in ethanolamine. The solubility of oxidized coal is found to correlate linearly with helium density, specific energy, acid equivalents, and carboxyl acidity on univariate basis with correlation coefficients of 0.88, 0.996, 0.992, and 0.995, respectively. 相似文献
8.
Kedar G. Kale Adrian J. Lew 《International journal for numerical methods in engineering》2007,70(3):291-321
This paper presents a scalable parallel variational time integration algorithm for nonlinear elastodynamics with the distinguishing feature of allowing each element in the mesh to have a possibly different time step. Furthermore, the algorithm is obtained from a discrete variational principle, and hence it is termed parallel asynchronous variational integrator (PAVI). The underlying variational structure grants it outstanding conservation properties. Based on a domain decomposition strategy, PAVI combines a careful scheduling of computations with fully asynchronous communications to provide a very efficient methodology for finite element models with even mild distributions of time step sizes. Numerical tests are shown to illustrate PAVI's performance on both slow and fast networks, showing scalability properties similar to the best parallel explicit synchronous algorithms, with lower execution time. Finally, a numerical example in which PAVI needs ≈100 times less computing than an explicit synchronous algorithm is shown. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
9.
Measurements of thermal conductivity and thermal diffusivity of twin pellets of Se80Te20-xInx (x = 2, 4, 6 and 10) glasses, prepared under a load of 5 tons were carried out at room temperature using transient plane source
(TPS) technique. The measured values of both thermal conductivity and diffusivity were used to determine the specific heat
per unit volume of the said materials in the composition range of investigation. Results indicated that both the values of
thermal conductivity and thermal diffusivity increased with the addition of indium at the cost of tellurium whereas the specific
heat remained almost constant. This compositional dependence behaviour of the thermal conductivity and diffusivity has been
explained in terms of the iono-covalent type of bond which In makes with Se as it is incorporated in the Se-Te glass. 相似文献
10.
Non-Clairvoyant Scheduling for Minimizing Mean Slowdown 总被引:1,自引:0,他引:1
We consider the problem of scheduling dynamically arriving jobs in a non-clairvoyant setting, that is, when the size of a job in remains unknown until the job finishes execution. Our focus is on minimizing the mean slowdown, where the slowdown (also known as stretch) of a job is defined as the ratio of the flow time to the size of the job. We use resource augmentation in terms of allowing a faster processor to the online algorithm to make up for its lack of knowledge of job sizes. Our main result is that the Shortest Elapsed Time First (SETF) algorithm, a close variant of which is used in the Windows NT and Unix operating system scheduling policies, is a $(1+\epsilon)$-speed, $O((1/\epsilon)^5 \log^2 B)$-competitive algorithm for minimizing mean slowdown non-clairvoyantly, when $B$ is the ratio between the largest and smallest job sizes. In a sense, this provides a theoretical justification of the effectiveness of an algorithm widely used in practice. On the other hand, we also show that any $O(1)$-speed algorithm, deterministic or randomized, is $\Omega(\min(n,\log B))$-competitive. The motivation for resource augmentation is supported by an $\Omega(\min(n,B))$ lower bound on the competitive ratio without any speedup. For the static case, i.e., when all jobs arrive at time 0, we show that SETF is $O(\log{B})$ competitive without any resource augmentation and also give a matching $\Omega(\log{B})$ lower bound on the competitiveness. 相似文献