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Vaibhav Vilas Andhalkar Shin Ying Foong Seng Hon Kee Su Shiung Lam Yi Herng Chan Ridha Djellabi Kesaven Bhubalan Francesc Medina Magdalena Constantí 《大分子材料与工程》2023,308(11):2300100
To support and move toward a sustainable bioeconomy, the production of polyhydroxyalkanoates (PHAs) using renewable biomass has acquired more attention. However, expensive biomass pretreatment and low yield of PHAs pose significant disadvantages in its large-scale production. To overcome such limitations, the most recent advances in metabolic engineering strategies used to develop high-performance strains that are leading to a new manufacturing concept converting biomass to PHAs with co-products such as amino acids, proteins, biohydrogen, biosurfactants, and various fine chemicals are critically summarized. This review article presents a comprehensive roadmap that highlights the integrated biorefinery strategies, lifecycle analysis, and techno-economic assessment for sustainable and economic PHAs production. Finally, current and future challenges that must be addressed to transfer this technology to real-world applications are reviewed. 相似文献
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