A 0.18-/spl mu/m SiGe BiCMOS receiver and transmitter chipset for SONET OC-768 transmission systems

A 43-Gb/s receiver (Rx) and transmitter (Tx) chip set for SONET OC-768 transmission systems is reported. Both ICs are implemented in a 0.18-/spl mu/m SiGe BiCMOS technology featuring 120-GHz f/sub T/ and 100 GHz f/sub max/. The Rx includes a limiting amplifier, a half-rate clock and data recovery unit, a 1:4 demultiplexer, a frequency acquisition aid, and a frequency lock detector. Input sensitivity for a bit-error rate less than 10/sup -9/ is 40 mV and jitter generation better than 230 fs rms. The IC dissipates 2.4 W from a -3.6-V supply voltage. The Tx integrates a half-rate clock multiplier unit with a 4:1 multiplexer. Measured clock jitter generation is better than 170 fs rms. The IC consumes 2.3 W from a -3.6-V supply voltage.     

Performance Evaluation of Dynamic Speculative Multithreading with the Cascadia Architecture

Thread-level parallelism (TLP) has been extensively studied in order to overcome the limitations of exploiting instruction-level parallelism (ILP) on high-performance superscalar processors. One promising method of exploiting TLP is Dynamic Speculative Multithreading (D-SpMT), which extracts multiple threads from a sequential program without compiler support or instruction set extensions. This paper introduces Cascadia, a D-SpMT multicore architecture that provides multigrain thread-level support and is used to evaluate the performance of several benchmarks. Cascadia applies a unique sustainable IPC (sIPC) metric on a comprehensive loop tree to select the best performing nested loop level to multithread. This paper also discusses the relationships that loops have on one another, in particular, how loop nesting levels can be extended through procedures. In addition, a detailed study is provided on the effects that thread granularity and interthread dependencies have on the entire system.     

Stabilizing and destabilizing effects of drug-excipient interactions in spray-dried,freeze-dried,and granulated Sennae fructus extracts

Abstract

The objective of this study was to compare spray-dried and freeze-dried extracts of Sennae fructus regarding the stability of the sennosides. Therefore, the influence of the addition of maltodextrin (MD) not only before the drying processes but also during fluidized bed granulation was investigated. Analysis of the hygroscopicities, the simultaneous TGA-DSC-MS data, and the influence of storage revealed that spray-dried extracts are more stable than freeze-dried extracts. The addition of MD led to an even better stability of the extracts. Lower amounts of MD are sufficient if applied onto the surface of the native extract during fluidized bed granulation.     

Comparison of several approaches to the linear approximation of the yield condition and application to the robust design of plane frames for the case of uncertainty

Since the yield condition for frame structures is non-linear, piecewise linear approximations are needed in order to apply linear optimization methods. Four approaches are presented and compared. After the theoretical consideration and comparison of the different approximation methods, they are applied to the robust design of an 18-bar frame in case of uncertainty. Here, the less restrictive methods yield the cheapest design, as expected. It will be shown, that the approximation from inside of first level does not cause much higher costs than the other methods. But since its constraints are sufficient in contrast to other approximations, it is recommended.     

Factors influencing the properties and the stability of spray-dried Sennae fructus extracts

Objective: The objective of this study was to characterize the properties of aqueous Sennae fructus extracts prepared by spray-drying at varying process conditions.

Significance: From an industrial point of view it is essential to develop a formulation which has a constant quality over the whole period of its specified shelf-life.

Method: Sennae fructus extracts were spray-dried with different atomizing gas pressures, pump feed rates, and inlet temperatures. The extracts were analyzed for their physical properties and stored at accelerated conditions. Sennoside degradation was monitored by HPLC analysis.

Results: An increase of the atomizing gas pressure had the most pronounced influence on the decrease of moisture content and particle size. An increase of the inlet temperature led to a decrease of moisture content and particle density, as well as an increase of smooth particle amount. An increase in the pump feed rate, increased the moisture content and resulted in stable hollow spheres. The different conditions also led to smooth or wrinkled particle surfaces, and to golfball, donut, and shard particle shapes. The chemical stability of the sennosides differed from each other after storage. Stability-reducing factors were the moisture content of the samples and their hygroscopicities, as well as different particle morphologies. These factors were influenced by the inlet temperature of the spray-drying process. High inlet temperatures led to a positive influence on dryness and particle morphology and therefore on the stability of the sennosides.

Conclusions: Variation of the process conditions affected the resulting particle properties and their storage stability of Sennae fructus extract.     

勘察设计行业信息系统开发理念浅谈

目前勘察设计行业信息化建设中存在多种弊端,如何对症下药使行业信息化走上良性循环的发展道路是信息主管部门必须深层考虑的问题。在知识大爆炸得今天,应该说进行知识管理是勘察设计行业信息化的捷径。     

空调工况下地铁站台PM2.5动态变化特性与影响因素分析

本文以空调工况下地铁站台区域PM值为研究对象,采用现场动态监测的方法,对上海某地铁车站站台1. 5 m高度典型代表点及站台典型送风口和回风口处、屏蔽门附近、楼梯处和新风井区域的PM值和温湿度值进行动态监测,获得站台及其相关因素PM值的动态变化特性。结果表明:送风口平均PM值比站台平均PM值高25μg/m3,站台屏蔽门附近处平均PM值比站台平均PM值高50μg/m3。本文还利用CFD软件进行数值模拟,并通过正交试验数学方法分析各因素对站台PM浓度影响的显著性,结果表明:送风口PM和屏蔽门PM对站台PM值影响非常显著,送风口风速和回风口风速对站台PM值影响显著,送风温度、屏蔽门处温度和站台温度对站台PM值影响不显著。     

Tumour cell vaccines that secrete interleukin-2 (IL-2) and interferon gamma (IFN gamma) are recognised by T cells while resisting destruction by natural killer (NK) cells

The inoculation into mice of genetically engineered tumour cells that secrete IL-2 or IFN gamma results in rejection, while unmodified parental tumour cells grow progressively. In vivo studies demonstrated synergy between IL-2 and IFN gamma leading to the rejection of the transduced tumour cells. IL-2 is required for T cell proliferation and differentiation. IFN gamma induced the upregulation of MHC class I molecules that present peptides to CD8+ T cells. Furthermore, IFN gamma can correct defects in antigen processing. Thus, for T cells, IL-2/IFN gamma-secreting double cytokine tumour cell vaccines might serve as class I+ peptide/antigen presenting depots for developing effector cells. In contrast to T cells, NK cells exert spontaneous killing and kill class I+ targets less well than those that are class I-. For this reason, they may actually have a detrimental effect by destroying a class I+ tumour cell vaccine before adequate T cell stimulation occurs. Based upon this rationale, we tested the hypothesis that an unrecognised benefit of increased class I expression by tumour cells in response to IFN gamma secretion would be to enable cytokine-secreting vaccine cells to resist destruction by NK cells. Our results demonstrated that T cells recognised tumour cells secreting IFN gamma better than those secreting IL-2. NK cells, in contrast, were inhibited by tumour cells that secreted IFN gamma, but not by those that secreted IL-2. The findings suggest that, in addition to upregulating adhesion molecules, MHC molecules, and correcting defects in antigen presentation pathways, IFN gamma secretion may protect tumour cell vaccines from early NK-mediated destruction, keeping them available for T cell priming.