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1.
Gordenchuk A. D. Kudryashova O. S. 《Theoretical Foundations of Chemical Engineering》2019,53(4):591-595
Theoretical Foundations of Chemical Engineering - Calcium formate is widely used in construction, tanning, and textile manufacture and as an E238 biological additive in cosmetology and the food... 相似文献
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Songyu Dong Weili Zheng Nicholas Pinkerton Jacob Hansen Svetlana B. Tikunova Jonathan P. Davis Sarah M. Heissler Elena Kudryashova Edward H. Egelman Dmitri S. Kudryashov 《International journal of molecular sciences》2022,23(13)
Due to its essential role in cellular processes, actin is a common target for bacterial toxins. One such toxin, TccC3, is an effector domain of the ABC-toxin produced by entomopathogenic bacteria of Photorhabdus spp. Unlike other actin-targeting toxins, TccC3 uniquely ADP-ribosylates actin at Thr-148, resulting in the formation of actin aggregates and inhibition of phagocytosis. It has been shown that the fully modified F-actin is resistant to depolymerization by cofilin and gelsolin, but their effects on partially modified actin were not explored. We found that only F-actin unprotected by tropomyosin is the physiological TccC3 substrate. Yet, ADP-ribosylated G-actin can be produced upon cofilin-accelerated F-actin depolymerization, which was only mildly inhibited in partially modified actin. The affinity of TccC3-ADP-ribosylated G-actin for profilin and thymosin-β4 was weakened moderately but sufficiently to potentiate spontaneous polymerization in their presence. Interestingly, the Arp2/3-mediated nucleation was also potentiated by T148-ADP-ribosylation. Notably, even partially modified actin showed reduced bundling by plastins and α-actinin. In agreement with the role of these and other tandem calponin-homology domain actin organizers in the assembly of the cortical actin network, TccC3 induced intense membrane blebbing in cultured cells. Overall, our data suggest that TccC3 imposes a complex action on the cytoskeleton by affecting F-actin nucleation, recycling, and interaction with actin-binding proteins involved in the integration of actin filaments with each other and cellular elements. 相似文献
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Dyakin V. V. Kudryashova O. V. Raevskii V. Ya. 《Russian Journal of Nondestructive Testing》2018,54(12):840-848
Russian Journal of Nondestructive Testing - The two-dimensional problem of magnetostatics has been solved by calculating the resultant field of the plate with a surface defect, placed in a... 相似文献
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Kudryashova Elena V.; Artemova Tatiana M.; Vinogradov Alexei A.; Gladilin Alexander K.; Mozhaev Vadim V.; Levashov Andrey V. 《Protein engineering, design & selection : PEDS》2003,16(4):303-309
Formation of enzymeoligoamine complexes was suggestedas an approach to obtain biocatalysts with enhanced resistancetowards inactivation in waterorganic media. Complex formationresults in broadening (by 2040% v/v ethanol) of the rangeof cosolvent concentrations where the enzyme retains its catalyticactivity (stabilization effect). At moderate cosolvent concentrations(2040% v/v) complex formation activates the enzyme (by36 times). The magnitude of activation and stabilizationeffects increases with the number of possible electrostaticcontacts between the protein surface and the molecules of oligoamines(OA). Circular dichroism spectra in the far-UV region show thatcomplex formation stabilizes protein conformation and preventsaggregation in waterorganic solvent mixtures. Two populationsof the complexes with different thermodynamic stabilities werefound in -chymotrypsin (CT)OA systems depending on theCT/OA ratio. The average dissociation constants and stoichiometriesof both low- and high-affinity populations of the complexeswere estimated. It appears that it is the low-affinity siteson the CT surface that are responsible for the activation effect. 相似文献
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T. A. Kudryashova S. V. Polyakov A. A. Sverdlin 《Mathematical Models and Computer Simulations》2009,1(4):445-452
An original numerical algorithm for calculating the gas parameters around a reentry vehicle was described and tested. It is based on a system of Quasi Gas Dynamics (QGD) equations and its approximations on hybrid meshes, which suppose adaptive, locally thickening meshes including both rectangular and triangular cells. The results of the calculations on a sequence of condensed meshes for Mach number values of 2, 5, and 12 are presented. These results correspond to well-known data and demonstrate the high efficiency of the algorithm. 相似文献
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Zh. F. Kudryashova 《Measurement Techniques》1991,34(3):221-225
Translated from Izmeritel'naya Tekhnika, No. 3, pp. 3–5, March, 1991. 相似文献