Maternal nutrition and socio-economic status as determinants of birthweight in chronically malnourished African women

The birthweight is the most important determinant of mortality and morbidity in the neonatal period and may have an influence on health in adult life. The high rate of low birthweight in developing countries is therefore a major health problem. Maternal malnutrition is usually assumed to be a causal factor but other environmental factors are also involved. In this study we analysed maternal nutritional and socio-economic factors as determinants of birthweight in term infants from a rural African society characterised by a high rate of chronic malnutrition. Relations of maternal weight, gestational weight gain, parity, socio-economic status and infant sex with birthweight were analysed in 1,477 women and child pairs. The selected women were followed from early pregnancy and had an uncomplicated delivery at term of a living singleton child. The gestational weight gain was 5.6 (SD 6.0) kg and the mean birthweight 2.933 kg (SD 408). Maternal weight, representing the maternal long-term nutritional situation, was the most important independent determinant of birthweight, accounting for 13.0% of the variance in birthweight. The weight gain, representing the short-term nutritional situation, explained only 5.6% of the variance. Birthweight increased by 20 g (CI 18-23) for each kg maternal weight and by 15 g (CI 12-18) for each kg gestational weight gained. The socio-economic difference in birth-weight was 153 g (CI 109-196) 88 of which (CI 48-128) remained unexplained after adjustment for differences in maternal weight, parity and gender. Improved long-term nutritional situation and living conditions seems to be the most important prerequisites to counteract low birthweight in developing countries.     

HIV-1 and HIV-2 antibodies in pregnant women in the City of Maputo, Mozambique. A comparative study between 1982/1983 and 1990

The seroprevalence of HIV-1 and HIV-2 among pregnant women in Maputo, the capital of Mozambique, was compared between the years 1982/83, 1988 and 1990. None of the 432 serum samples collected in 1982/83 was positive for HIV antibodies whereas in 1988 the HIV-1 and HIV-2 seroprevalence was 0.4% (2/500) and 0.6% (3/500), respectively, and in 1990 0.6% (12/2014) and 0.2% (4/2014), respectively. These results indicate that HIV infection has been introduced recently in Maputo and is spreading at a slow rate among women.     

Property Owning and Democracy-Do the Twain Ever Meet?

Starting from the Conservative assertion that home ownership fosters politically active and virtuous citizens, this paper examines two lines of argument in housing theory; (a) Jim Kemeny's thesis that owner occupation is closely linked to increasing privatism, i.e. a growth in lifestyles centred around the home and privacy rather than the workplace or the public affairs in a society, and (b) Peter Saunders' thesis that home owners will organise and mobilise politically in defence of their property interests if and when various government agencies threaten to remove their tax subsidies. To test these propositions empirically, data on the effects of the rapid and comprehensive dismantling of tax privileges to Swedish home owners in the 1980s and early 1990s are confronted with data on political interest, participation and knowledge as well as civic trust and responsibility from the Swedish election surveys of 1979, 1985 and 1991. Contrary to Conservative beliefs, home owners do not stand out as 'democratic examples'; with the exception of political knowledge and party membership, they are no more 'civil' or 'democratic' than other citizens. There is also not much to support Kemeny's 'privatism' or Saunders' 'reaction-to-threat' theses. Although home owners in Sweden saw their tax privileges diminishing rapidly during the 1980s and early 1990s, they do not show the distinctive patterns of change in democratic orientation and spirit predicted by these two housing theorists. To allow for an even more conclusive test of Kemeny's 'privatism' thesis, however, one must overcome the mismatch of income definitions in housing statistics and election survey data.     

Remarks on the mean square tracking error

The purpose of this paper is to extend recent results of Ljung and Priouret to a more general class of regressors.     

Psychometric considerations in the dimensional analysis of subjective picture quality

A discussion of the factors involved in the subjective perception of television picture quality is presented. Much of the work in this field is cited, and it is concluded that future work needs to consider a broader range of variables than has been looked at so far.     

Surface exposure and species specificity of an immunoreactive domain of a 66-kilodalton outer membrane protein (P66) of the Borrelia spp. that cause Lyme disease

A chromosomally encoded 66-kDa protein (P66) of Borrelia spp. that cause Lyme disease has previously been shown to be associated with the spirochetal outer membrane. A topological model of P66 predicts a surface-exposed fragment which links the N- and C-terminal intramembranous domains of the protein (J. Bunikis, L. Noppa, and S. Bergstr?m, FEMS Microbiol. Lett. 131:139-145, 1995). In the present study, an immunogenic determinant of P66 was identified by a comparison of the immunoreactivities of different fragments of P66 generated either by proteolytic treatment of intact spirochetes or as recombinant proteins expressed in Escherichia coli. The immune response to P66 during natural infection was found to be directed against the predicted surface domain which comprises amino acids at positions 454 through 491. A sequence comparison revealed considerable polymorphism of the surface domains of P66 proteins of different Lyme disease-causing Borrelia species. Five sequence patterns of this domain were observed in the B. garinii strains studied. In contrast, sequences of the relevant part of P66 of the B. afzelii and B. burgdorferi sensu stricto isolates studied were identical within the respective species. In immunoblotting, 5 of 17 (29.4%) sera from North American patients with early disseminated or persistent Lyme disease reacted against P66 of B. burgdorferi sensu stricto B31. These sera, however, failed to recognize P66 of B. afzelii and B. garinii, as well as an analog of P66 in the relapsing fever agent, B. hermsii. In conclusion, the topological model of P66 is supported by the demonstration of an apparent surface localization of an immunoreactive domain of this protein. Furthermore, analogous to the plasmid-encoded borrelial outer surface proteins, the predicted surface-exposed portion of chromosomally encoded P66 appears to be antigenically heterogenous.     

Performance analysis of general tracking algorithms

A general family of tracking algorithms for linear regression models is studied. It includes the familiar least mean square gradient approach, recursive least squares, and Kalman filter based estimators. The exact expressions for the quality of the obtained estimates are complicated. Approximate, and easy-to-use, expressions for the covariance matrix of the parameter tracking error are developed. These are applicable over the whole time interval, including the transient, and the approximation error can be explicitly calculated     

Nonlinear black-box modeling in system identification: a unified overview

A nonlinear black-box structure for a dynamical system is a model structure that is prepared to describe virtually any nonlinear dynamics. There has been considerable recent interest in this area, with structures based on neural networks, radial basis networks, wavelet networks and hinging hyperplanes, as well as wavelet-transform-based methods and models based on fuzzy sets and fuzzy rules. This paper describes all these approaches in a common framework, from a user's perspective. It focuses on what are the common features in the different approaches, the choices that have to be made and what considerations are relevant for a successful system-identification application of these techniques. It is pointed out that the nonlinear structures can be seen as a concatenation of a mapping form observed data to a regression vector and a nonlinear mapping from the regressor space to the output space. These mappings are discussed separately. The latter mapping is usually formed as a basis function expansion. The basis functions are typically formed from one simple scalar function, which is modified in terms of scale and location. The expansion from the scalar argument to the regressor space is achieved by a radial- or a ridge-type approach. Basic techniques for estimating the parameters in the structures are criterion minimization, as well as two-step procedures, where first the relevant basis functions are determined, using data, and then a linear least-squares step to determine the coordinates of the function approximation. A particular problem is to deal with the large number of potentially necessary parameters. This is handled by making the number of ‘used’ parameters considerably less than the number of ‘offered’ parameters, by regularization, shrinking, pruning or regressor selection.     

Renal sodium excretion after oral or intravenous sodium loading in sodium-deprived normotensive and spontaneously hypertensive rats

Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats that had been on a low sodium diet for 3 days were given 1.5 mmol sodium chloride kg-1 body weight either orally or intravenously. The rats receiving an oral sodium load showed a greater natriuresis than those receiving the same saline load intravenously. No increase of renal sodium excretion was observed when the rats received a hypertonic mannitol solution orally. The cumulative sodium excretion during the 8 h following oral loading was two to three times larger in SHR than in WKY, whereas no difference between strains could be demonstrated after giving saline intravenously. Furthermore, after switching from normal to low sodium diet the rate of decrease of renal sodium excretion was greater in SHR than in WKY rats. It is proposed that there exists a gastrointestinal sensory mechanism for sodium controlling the renal sodium excretion. Furthermore, it is suggested that the function of this mechanism differs between SHR and WKY.     

Performance analysis of the forgetting factor RLS algorithm

An analysis is given of the performance of the standard forgetting factor recursive least squares (RLS) algorithm when used for tracking time-varying linear regression models. Three basic results are obtained: (1) the ‘P-matrix’ in the algorithm remains bounded if and only if the (time-varying) covariance matrix of the regressors is uniformly non-singular; (2) if so, the parameter tracking error covariance matrix is of the order O(μ + γ²/μ), where μ = 1 - λ, λ is the forgetting factor and γ is a quantity reflecting the speed of the parameter variations; (3) this covariance matrix can be arbitrarily well approximated (for small enough μ) by an expression that is easy to compute.