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1.
Dr. Erika Lisztes Dr. Erika Mező Fruzsina Demeter Lilla Horváth Dr. Szilvia Bősze Dr. Balázs István Tóth Prof. Anikó Borbás Dr. Mihály Herczeg 《ChemMedChem》2021,16(9):1467-1476
The design and synthesis of heparin mimetics with high anticancer activity but no anticoagulant activity is an important task in medicinal chemistry. Herein, we present the efficient synthesis of five Glc-GlcA-Glc-sequenced and one Glc-IdoA-Glc-sequenced non-glycosaminoglycan, heparin-related trisaccharides with various sulfation/sulfonylation and methylation patterns. The cell growth inhibitory effects of the compounds were tested against four cancerous human cell lines and two non-cancerous cell lines. Two d -glucuronate-containing tetra-O-sulfated, partially methylated trisaccharides displayed remarkable and selective inhibitory effects on the growth of ovary carcinoma (A2780) and melanoma (WM35) cells. Methyl substituents on the glucuronide unit proved to be detrimental, whereas acetyl substituents were beneficial to the cytostatic activity of the sulfated derivatives. 相似文献
2.
Chianese L Caira S Lilla S Pizzolongo F Ferranti P Pugliano G Addeo F 《The Journal of dairy research》2004,71(1):14-19
A novel electrophoretic alpha-lactalbumin (alpha-la) variant was detected in the Italian water buffalo breed. The isoelectric point of the variant, labelled A, was lower than the most frequent variant B. It presented an allelic frequency of 0.5% compared with the 97.1% of the BB allele. From Liquid Chromatography-Electrospray Ionization/Mass spectrometry, the molecular mass of the two alpha-la A and B variants were measured as 14,235.1+/-0.8 and 14,236.1+/-0.9 Da, respectively. The two proteins were sequenced and differentiated from one another by a single amino acid substitution, Asn45(B)-->Asp45(A). As this amino acid substitution altered the N-glycosylation sequence consensus Asn45-X-Ser46 it may be deduced that the protein glycosylation level of the alpha-la A would decrease. 相似文献
3.
Wilson Quevedo Christian Peth Gerhard Busse Mirko Scholz Klaus Mann Simone Techert 《International journal of molecular sciences》2009,10(11):4754-4771
Home-based soft X-ray time-resolved scattering experiments with nanosecond time resolution (10 ns) and nanometer spatial resolution were carried out at a table top soft X-ray plasma source (2.2–5.2 nm). The investigated system was the lyotropic liquid crystal C16E7/paraffin/glycerol/formamide/IR 5. Usually, major changes in physical, chemical, and/or optical properties of the sample occur as a result of structural changes and shrinking morphology. Here, these effects occur as a consequence of the energy absorption in the sample upon optical laser excitation in the IR regime. The liquid crystal shows changes in the structural response within few hundred nanoseconds showing a time decay of 182 ns. A decrease of the Bragg peak diffracted intensity of 30% and a coherent macroscopic movement of the Bragg reflection are found as a response to the optical pump. The Bragg reflection movement is established to be isotropic and diffusion controlled (1 μs). Structural processes are analyzed in the Patterson analysis framework of the time-varying diffraction peaks revealing that the inter-lamellar distance increases by 2.7 Å resulting in an elongation of the coherently expanding lamella crystallite. The present studies emphasize the possibility of applying TR-SXRD techniques for studying the mechanical dynamics of nanosystems. 相似文献
4.
Peth C Kalinin A Barkusky F Mann K Toennies JP Rusin LY 《The Review of scientific instruments》2007,78(10):103509
We present a laser driven soft x-ray source based on a novel solid argon filament. The continuously flowing micron-sized filament (diameter approximately 56 microm, flow speed approximately 5 mms) was used as a laser target in order to generate a plasma source of high brightness in the "water window" (2.2-4.4 nm) spectral range. The emission properties of the source were characterized in detail with respect to crucial parameters such as positional and energy stability using an extreme ultraviolet (XUV) sensitive pinhole camera and an XUV spectrometer. The results are compared with an argon plasma based on a gas puff target operated under the same experimental conditions showing an increase of the brilliance by a factor of 84. By changing the capillary geometry from a constant diameter to a convergent shape the flow speed of the filament was significantly increased up to 250 mms, facilitating the operation at higher repetition rates. 相似文献
5.
Sándor Tömösközi Lilla Gyenge Ágnes Pelcéder János Varga Tibor Abonyi Radomir Lásztity 《European Food Research and Technology》2008,226(6):1343-1348
The gross chemical composition and functional properties (solubility, emulsifying and foaming properties) of different amaranth
protein preparations were studied in model systems and were compared to those of casein and soy protein isolates. Preparations
of alkaline-soluble total protein, albumin, globulin, and glutelin-like alkaline-soluble residual protein were produced from
two different types of defatted amaranth meals by extraction and fractionation. Although similarity can be shown between protein
patterns of legumes (including soy) and amaranth, the emulsifying and foaming properties of amaranth protein preparations
are relatively poor in comparison to the reference proteins, except foaming properties of albumin preparations. Nevertheless,
taking in mind that these properties depend on interactions with other food components and textural requirements of individual
food products, the amaranth protein preparations may be treated as potential protein sources and food ingredients. 相似文献
6.
Veronika Bilanovi
ov Nikola Rýdza Lilla Koczka Martin Hess Elena Feraru Jií Friml Tomasz Nodzyski 《International journal of molecular sciences》2022,23(11)
Much of plant development depends on cell-to-cell redistribution of the plant hormone auxin, which is facilitated by the plasma membrane (PM) localized PIN FORMED (PIN) proteins. Auxin export activity, developmental roles, subcellular trafficking, and polarity of PINs have been well studied, but their structure remains elusive besides a rough outline that they contain two groups of 5 alpha-helices connected by a large hydrophilic loop (HL). Here, we focus on the PIN1 HL as we could produce it in sufficient quantities for biochemical investigations to provide insights into its secondary structure. Circular dichroism (CD) studies revealed its nature as an intrinsically disordered protein (IDP), manifested by the increase of structure content upon thermal melting. Consistent with IDPs serving as interaction platforms, PIN1 loops homodimerize. PIN1 HL cytoplasmic overexpression in Arabidopsis disrupts early endocytic trafficking of PIN1 and PIN2 and causes defects in the cotyledon vasculature formation. In summary, we demonstrate that PIN1 HL has an intrinsically disordered nature, which must be considered to gain further structural insights. Some secondary structures may form transiently during pairing with known and yet-to-be-discovered interactors. 相似文献
7.
8.
H. Peth 《Materialwissenschaft und Werkstofftechnik》1975,6(11):367-376
The “Wettingbalance”, a new aid for testing softsoldering fluxes . A new method for the determination of behaviour of materials related to soft solderability, evaluates the forces acting on immersed samples, which are significant for the achieved wetting quality. The influence of various factors such as condition of the samplesurface, flux and solder are sensitively registered and allow their objectiv assessment. Sofar the wettingcurves are mostly interpreted from a qualitative point of view. The presented method, taking the comparative testing of fluxes as an example, describes the quantitative evaluation of the wetting behaviour. In the beginning a summary of the physical background of the process as well as few remarks relatet to the experimental procedure are given. 相似文献
9.
Daniella Fehr Andrea Ferencz Gyrgyi Szab Krisztina Juhos Domokos Csuks Constantinos Voniatis Lilla Reininger Kristf Molnr Angla JedlovszkyHajdú Gyrgy Wber 《IET nanobiotechnology / IET》2021,15(6):565
Hernia is a defect of the abdominal wall. Treatment is principally surgical mesh implantation. Non‐degradable surgical meshes produce numerous complications and side‐effects such as inflammatory response, mesh migration and chronic pain. In contrast, the biodegradable, poly (vinyl alcohol) (PVA) based polymers have excellent chemical, mechanical and biological properties and after their degradation no chronic pain can be expected. The toxicology of PVA solution and fibers was investigated with Human dermal fibroblast‐ Adult cell line. Implantation tests were observed on long‐term contact (rat) and large animal (swine) models. To measure the adhesion formation, Diamond and Vandendael score were used. Macroscopical and histological responses were graded from the samples. In vitro examination showed that PVA solution and fibers are biocompatible for the cells. According to the implantation tests, all samples were integrated into the surrounding tissue, and there was no foreign body reaction. The average number of adhesions was found on the non‐absorbable suture line. The biocompatibility of the PVA nanofiber mesh was demonstrated. It has a non‐adhesive, non‐toxic and good quality structure which has the potential to be an alternative solution for the part of the hernia mesh. 相似文献
10.
A new push‐pull sample design for microscale mode 1 fracture toughness measurements under uniaxial tension
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J.J. Schwiedrzik J. Ast L. Pethö X. Maeder J. Michler 《Fatigue & Fracture of Engineering Materials & Structures》2018,41(5):991-1001
A sample geometry is proposed for performing microscale tensile experiments based on a push‐pull design. It allows measuring mode 1 fracture toughness under uniform far‐field loading. Finite element simulations were performed to determine the geometry factor, which was nearly constant for Young's moduli spanning 2 orders of magnitude. It was further verified that mode 1 stress intensity factor KI is nearly constant over the width of the tension rods and an order of magnitude higher than KII and KIII. Notched samples with different a/w ratios were prepared in (100)‐oriented Si by a combination of reactive ion etching and focused ion beam milling. The mode 1 fracture toughness KI,q was constant with a/w and in average 1.02 ± 0.06 MPa√m in good agreement with existing literature. The geometry was characterized and experimentally validated and may be used for fracture toughness measurements of all material classes. It is especially interesting when a uniaxial, homogeneous stress field is desired, if crack tip plasticity is important, or when positioning of the indenter is difficult. 相似文献