Revival by automation of induction generator for distributed power systems, in Romanian academic research

The paper approaches the half-century history and the main research results of the academic staff and researchers from “Politehnica” University of Timisoara (Universitatea “Politehnica” Timisoara—UPT) and their collaboration with the academic, research and production environment concerning the use of induction machine as power supply in microhydro plants and windmills in particular; from among these collaborators we mention: The Romanian Academy—Timisoara Branch, The Institute for Automation IPA—Timisoara Branch, The Research and Modernization Institute for Energetics ICEMENERG Bucharest, The National Institute for Heat Engines INMT Bucharest, The Machine Construction Works UCMR—Resita, “Electroputere” Works—Craiova and “Electromotor” Works—Timisoara.The paper aims at presenting the original research results at UPT against the background of general research from all over the world focused on revival the induction generator by automation.     

Cellular and Molecular Profiling of Tumor Microenvironment and Early-Stage Lung Cancer

Lung cancers are broadly divided into two categories: non-small-cell lung carcinoma (NSCLC), which accounts for 80–85% of all cancer cases, and small-cell lung carcinoma (SCLC), which covers the remaining 10–15%. Recent advances in cancer biology and genomics research have allowed an in-depth characterization of lung cancers that have revealed new therapy targets (EGFR, ALK, ROS, and KRAS mutations) and have the potential of revealing even more biomarkers for diagnostic, prognostic, and targeted therapies. A new source of biomarkers is represented by non-coding RNAs, especially microRNAs (miRNAs). MiRNAs are short non-coding RNA sequences that have essential regulatory roles in multiple cancers. Therefore, we aim to investigate the tumor microenvironment (TME) and miRNA tumor profile in a subset of 51 early-stage lung cancer samples (T1 and T2) to better understand early tumor and TME organization and molecular dysregulation. We analyzed the immunohistochemistry expression of CD4 and CD8 as markers of the main TME immune populations, E-cadherin to evaluate early-stage epithelial-to-mesenchymal transition (EMT), and p53, the main altered tumor suppressor gene in lung cancer. Starting from these 4 markers, we identified and validated 4 miRNAs that target TP53 and regulate EMT that can be further investigated as potential early-stage lung cancer biomarkers.