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排序方式: 共有69条查询结果,搜索用时 15 毫秒
1.
Influence of electroosmotic treatment on the hydro-mechanical behaviour of clayey silts: preliminary experimental results 总被引:1,自引:0,他引:1
Laura Gabrieli Cristina Jommi Guido Musso Enrique Romero 《Journal of Applied Electrochemistry》2008,38(7):1043-1051
Preliminary results of an investigation focused on the influence of electrokinetic treatment on the mechanical and hydraulic
behaviour of clayey soils are presented. The experimental programme aims at providing a contribution to the sustainability
of contaminant extraction or containment via electroosmosis. Changes in the hydraulic and mechanical properties of two illitic
clayey soils, subjected to a DC electric field, were investigated. Samples of the two soils were subjected to electrokinetic
filtration, for different periods of time, and under different constant loads. Afterwards, they were tested under one-dimensional
compression to detect changes in stiffness and hydraulic conductivity due to the electrical treatment. After the application
of a DC field for a few hours, a small reversible increment in the average soil stiffness was observed, with respect to the
untreated soil, while the hydraulic conductivity was not affected substantially. Dramatic changes of the mechanical and hydraulic
soil properties, correlated to changes of the soil pH, were observed following non-conditioned electrokinetic treatment with
duration of the order of days. 相似文献
2.
Andrea Kunova Luca Palazzolo Fabio Forlani Giorgia Catinella Loana Musso Paolo Cortesi Ivano Eberini Andrea Pinto Sabrina Dallavalle 《International journal of molecular sciences》2021,22(7)
The increasing emergence of fungicide-resistant pathogens requires urgent solutions for crop disease management. Here, we describe a structural investigation of new fungicides obtained by combining strobilurin and succinate dehydrogenase inhibitor pharmacophores. We identified compounds endowed with very good activity against wild-type Pyricularia oryzae, combined in some cases with promising activity against strobilurin-resistant strains. The first three-dimensional model of P. oryzae cytochrome bc1 complex containing azoxystrobin as a ligand was developed. The model was validated with a set of commercially available strobilurins, and it well explains both the resistance mechanism to strobilurins mediated by the mutation G143A and the activity of metyltetraprole against strobilurin-resistant strains. The obtained results shed light on the key recognition determinants of strobilurin-like derivatives in the cytochrome bc1 active site and will guide the further rational design of new fungicides able to overcome resistance caused by G143A mutation in the rice blast pathogen. 相似文献
3.
Claudia Giuseppina Fresta Giuseppe Caruso Annamaria Fidilio Chiara Bianca Maria Platania Nicol Musso Filippo Caraci Filippo Drago Claudio Bucolo 《International journal of molecular sciences》2020,21(23)
Activation of P2X7 signaling, due to high glucose levels, leads to blood retinal barrier (BRB) breakdown, which is a hallmark of diabetic retinopathy (DR). Furthermore, several studies report that high glucose (HG) conditions and the related activation of the P2X7 receptor (P2X7R) lead to the over-expression of pro-inflammatory markers. In order to identify novel P2X7R antagonists, we carried out virtual screening on a focused compound dataset, including indole derivatives and natural compounds such as caffeic acid phenethyl ester derivatives, flavonoids, and diterpenoids. Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) rescoring and structural fingerprint clustering of docking poses from virtual screening highlighted that the diterpenoid dihydrotanshinone (DHTS) clustered with the well-known P2X7R antagonist JNJ47965567. A human-based in vitro BRB model made of retinal pericytes, astrocytes, and endothelial cells was used to assess the potential protective effect of DHTS against HG and 2′(3′)-O-(4-Benzoylbenzoyl)adenosine-5′-triphosphate (BzATP), a P2X7R agonist, insult. We found that HG/BzATP exposure generated BRB breakdown by enhancing barrier permeability (trans-endothelial electrical resistance (TEER)) and reducing the levels of ZO-1 and VE-cadherin junction proteins as well as of the Cx-43 mRNA expression levels. Furthermore, HG levels and P2X7R agonist treatment led to increased expression of pro-inflammatory mediators (TLR-4, IL-1β, IL-6, TNF-α, and IL-8) and other molecular markers (P2X7R, VEGF-A, and ICAM-1), along with enhanced production of reactive oxygen species. Treatment with DHTS preserved the BRB integrity from HG/BzATP damage. The protective effects of DHTS were also compared to the validated P2X7R antagonist, JNJ47965567. In conclusion, we provided new findings pointing out the therapeutic potential of DHTS, which is an inhibitor of P2X7R, in terms of preventing and/or counteracting the BRB dysfunctions elicited by HG conditions. 相似文献
4.
Biosurfactants from Urban Wastes for Detergent Formulation: Surface Activity and Washing Performance
Piero Savarino Enzo Montoneri Giorgia Musso Vittorio Boffa 《Journal of surfactants and detergents》2010,13(1):59-68
To promote biobased products for industry, six biosurfactants (BS) isolated from green and food urban residues aged under
aerobic digestion for 0–60 days were investigated for their chemical composition, surface activity properties and detergent
performance in fabric washing in comparison with commercial anionic and nonionic surfactants (CS). The BS exhibited a range
of chemical composition and surface activity properties presumably related to their different biomass sources. Surface tension
data for these substances correlated meaningfully with performance data in fabric washing. It was found that BS have similar
performances as CS when used neat, but the 1:1 w/w BS–CS mixes are characterized by significant synergy. High sensitivity
to water hardness and fabric yellowing were found to be the main deficiencies for the BS. However, both effects are minimized
or are not critically evident when the BS are used together with CS and/or in common detergents formulations. The results
indicate that when used above critical micellar concentration, no significant or critical performance differences are evident
within the whole group of BS or between BS and CS. These facts encourage expectations for industrial production and real commercialization
of BS as components of detergents formulations. 相似文献
5.
We tested a method for comparing ECG signals (P waves), in a sample of 10 normal males. In each subject, sets of 219 body surface ECGs were simultaneously recorded during tidal respiration. Only beats at end expiration and peak inspiration were considered. The beats of each group were subdivided into two subgroups of the same size (about 30 beats) and separately averaged. The two averaged beats at end expiration, assumed to be equal, were compared in order to estimate the noise variance (sigma2), i.e., the lowest value of variance at which the beats were statistically similar (P less than 0.05). At the same value of sigma2, the beat at end expiration significantly differed from that at peak inspiration. By considering the individual leads, significant differences were found in more than 50% of the 219 ECGs, in specific thoracic areas. The data indicated that the method can reveal differences between P waves occurring during tidal respiration and provide information on the topographical distribution of the differences. 相似文献
6.
Room and elevated (450° C) temperature tensile data and room temperature notch impact data on weld metal and a welded joint of 10 wt % Cr-17.5 wt % Mn austenitic steel, a candidate material for thermonuclear fusion reactor first wall and blanket structures, are reported and discussed in terms of the microstructural features observed. 相似文献
7.
8.
Blanchard Edward B.; McCoy Guy C.; Wittrock David; Musso Alison; Gerardi Robert J.; Pangburn Linda 《Canadian Metallurgical Quarterly》1988,7(1):19
Compared progressive muscle relaxation (PMR), thermal biofeedback (BFB), and drug withdrawal (DW) as possible substitutes for 2nd-stage (sympatholytic) antihypertensive medications, using 73 hypertensive adults. Reactivity (heart rate, systolic blood pressure, and diastolic blood pressure) to 3 stressors (mental arithmetic, cold pressor, and negative mental imagery) was measured before and after PMR, BFB, and DW. PMR led to more reductions in some aspect of reactivity than did BFB. Reductions in reactivity were seen more for mental arithmetic and systolic blood pressure. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
CAGLIARI-PADOVA-TORINO Collaboration L. Cugusi M.P. Macciotta S. Marcello A. Masoni G. Puddu A. Raimondi S. Serci M.T. Sergi M. Agnello F. Iazzi B. Minetti T. Bressani A. Feliciello A. Musso R. Cherubini F. Gramegna M. Morandin J. Lichtenstadt 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》1988,270(2-3):354-360
The operating performances of a low-momentum (< 270 MeV/c) tagged
beam are reported. The
beam is obtained by means of the charge exchange reaction
n on a liquid hydrogen target. The neutron associated to the
in the two-body reaction is used for the determination of the
energy and direction. The measured total rate of tagged
is 8.02 ± 0.03 × 10−5 per incident
at 300 MeV/c. 相似文献
10.