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排序方式: 共有171条查询结果,搜索用时 15 毫秒
1.
Francesco Di Girolamo Andrea Masotti Isabella Lante Margherita Scapaticci Cosima Damiana Calvano Carlo Zambonin Maurizio Muraca Lorenza Putignani 《International journal of molecular sciences》2015,16(9):20896-20912
Extra virgin olive oil (EVOO) with its nutraceutical characteristics substantially contributes as a major nutrient to the health benefit of the Mediterranean diet. Unfortunately, the adulteration of EVOO with less expensive oils (e.g., peanut and corn oils), has become one of the biggest source of agricultural fraud in the European Union, with important health implications for consumers, mainly due to the introduction of seed oil-derived allergens causing, especially in children, severe food allergy phenomena. In this regard, revealing adulterations of EVOO is of fundamental importance for health care and prevention reasons, especially in children. To this aim, effective analytical methods to assess EVOO purity are necessary. Here, we propose a simple, rapid, robust and very sensitive method for non-specialized mass spectrometric laboratory, based on the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) coupled to unsupervised hierarchical clustering (UHC), principal component (PCA) and Pearson’s correlation analyses, to reveal corn oil (CO) adulterations in EVOO at very low levels (down to 0.5%). 相似文献
2.
Ferdinando Auricchio Lorenza Petrini 《International journal for numerical methods in engineering》2004,61(6):807-836
An always increasing knowledge on material properties as well as a progressively more sophisticated production technology make shape memory alloys (SMA) extremely interesting for the industrial world. At the same time, SMA devices are typically characterized by complex multi‐axial stress states as well as non‐homogeneous and non‐isothermal conditions both in space and time. This aspect suggests the finite element method as a useful tool to help and improve application design and realization. With this aim, we focus on a three‐dimensional macroscopic thermo‐mechanical model able to reproduce the most significant SMA features (Int. J. Numer. Methods Eng. 2002; 55 : 1255–1264), proposing a simple modification of such a model. However, the suggested modification allows the development of a time‐discrete solution algorithm, which is more effective and robust than the one previously discussed in the literature. We verify the computational tool ability to simulate realistic mechanical boundary value problems with prescribed temperature dependence, studying three SMA applications: a spring actuator, a self‐expanding stent, a coupling device for vacuum tightness. The effectiveness of the model to solve thermo‐mechanical coupled problems will be discussed in a forthcoming work. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
3.
Colzato Lorenza S.; Raffone Antonino; Hommel Bernhard 《Canadian Metallurgical Quarterly》2006,32(3):705
Four experiments were conducted to investigate the relationship between the binding of visual features (as measured by their aftereffects on subsequent binding) and the learning of feature-conjunction probabilities. Both binding and learning effects were obtained, but they did not interact. Interestingly, (shape-color) binding effects disappeared with increasing practice, presumably because of the fact that only 1 of the features involved was relevant to the task. However, this instability was only observed for arbitrary, not highly overlearned combinations of simple geometric features and not for real objects (colored pictures of a banana and strawberry), where binding effects were strong and resistant to practice. These findings suggest that learning has no direct impact on the strength or resistance of bindings or on speed with which features are bound; however, learning does affect the amount of attention particular feature dimensions attract, which again can influence which features are considered in binding. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
4.
Analysis and synthesis of attractive quantum Markovian dynamics 总被引:1,自引:0,他引:1
We propose a general framework for investigating a large class of stabilization problems in Markovian quantum systems. Building on the notions of invariant and attractive quantum subsystem, we characterize attractive subspaces by exploring the structure of the invariant sets for the dynamics. Our general analysis results are exploited to assess the ability of open-loop Hamiltonian and output-feedback control strategies to synthesize Markovian generators which stabilize a target subsystem, subspace, or pure state. In particular, we provide an algebraic characterization of the manifold of stabilizable pure states in arbitrary finite-dimensional Markovian systems, that leads to a constructive strategy for designing the relevant controllers. Implications for stabilization of entangled pure states are addressed by example. 相似文献
5.
We provide a general framework for constructing digital dynamical decoupling sequences based on Walsh modulation—applicable to arbitrary qubit decoherence scenarios. By establishing equivalence between decoupling design based on Walsh functions and on concatenated projections, we identify a family of optimal Walsh sequences, which can be exponentially more efficient, in terms of the required total pulse number, for fixed cancellation order, than known digital sequences based on concatenated design. Optimal sequences for a given cancellation order are highly non-unique—their performance depending sensitively on the control path. We provide an analytic upper bound to the achievable decoupling error and show how sequences within the optimal Walsh family can substantially outperform concatenated decoupling in principle, while respecting realistic timing constraints. 相似文献
6.
This review essentially deals with positive ion/molecule reactions occurring in gas-phase organometallic systems, and encompasses a period of time of approximately 7 years, going from 1997 to early 2004. Following the example of the excellent review by Eller & Schwarz (1991; Chem Rev 91:1121-1177), in the first part, results of reaction of naked ions are presented by grouping them according to the neutral substrate, while in the second part, ligated ions are grouped according to the different ligands. Whenever possible, comparison among similar studies is attempted, and general trends of reactivities are evidenced. 相似文献
7.
Ferdinando Auricchio Lorenza Petrini 《International journal for numerical methods in engineering》2004,61(5):716-737
Between composite materials, shape memory alloy (SMA) composites are having a more and more relevant role. Typically, SMA wires are embedded in a metallic or a polymeric matrix to obtain materials with native multi-functionality and adaptive properties. This work approaches the computational study of the mechanical response of a composite in which SMA wires, previously deformed, are activated by electrical current heating, and accordingly try to recover the original shape inducing a shape change or a prestress in the structure. In particular, since the SMA behaviour is strongly affected by the thermo-mechanical coupling, in the first part of this work we present a 3D phenomenological model able to take into account this aspect. The model time-discrete counterpart is used to develop a 3D solid finite element able to describe the thermo-electro-mechanical coupled problem due to shape memory alloy response and to Joule effect. Finally, in the second part of the paper, we employ the developed computational tool to simulate different feasible SMA composite applications. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
8.
Bianca Papotti Maria Pia Adorni Cinzia Marchi Francesca Zimetti Nicoletta Ronda Giovanni Panighel Maria Giovanna Lupo Antonietta Vilella Daniela Giuliani Nicola Ferri Franco Bernini 《International journal of molecular sciences》2022,23(20)
The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer’s disease (AD) is poorly investigated. We evaluated the in vitro PCSK9 modulation of astrocyte cholesterol metabolism and neuronal cholesterol supplying, which is fundamental for neuronal functions. Moreover, we investigated PCSK9 neurotoxic effects. In human astrocytoma cells, PCSK9 reduced cholesterol content (−20%; p < 0.05), with a greater effect in presence of beta amyloid peptide (Aβ) (−37%; p < 0.01). PCSK9 increased cholesterol synthesis and reduced the uptake of apoE-HDL-derived cholesterol (−36%; p < 0.0001), as well as the LDL receptor (LDLR) and the apoE receptor 2 (ApoER2) expression (−66% and −31%, respectively; p < 0.01). PCSK9 did not modulate ABCA1- and ABCG1-cholesterol efflux, ABCA1 levels, or membrane cholesterol. Conversely, ABCA1 expression and activity, as well as membrane cholesterol, were reduced by Aβ (p < 0.05). In human neuronal cells, PCSK9 reduced apoE-HDL-derived cholesterol uptake (−41%; p < 0.001) and LDLR/apoER2 expression (p < 0.05). Reduced cholesterol internalization occurred also in PCSK9-overexpressing neurons exposed to an astrocyte-conditioned medium (−39%; p < 0.001). PCSK9 reduced neuronal cholesterol content overall (−29%; p < 0.05) and increased the Aβ-induced neurotoxicity (p < 0.0001). Our data revealed an interfering effect of PCSK9, in cooperation with Aβ, on brain cholesterol metabolism leading to neuronal cholesterol reduction, a potentially deleterious effect. PCSK9 also exerted a neurotoxic effect, and thus represents a potential pharmacological target in AD. 相似文献
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