Thermisch induzierter Abbau von Disaccharid-Amadori-Verbindungen in quasi wasserfreiem Reaktionsmilieu

Ohne Zusammenfassung     

Antigenic stimuli do not influence thymic B lymphocytes: a morphological and functional study in germ-free and conventionally reared piglets

We have recently reported that thymic B lymphocytes (TBL) are the first B-cell subpopulation undergoing isotype switching to IgG and IgA during embryonic life. The aim of this study is to analyze the influence of antigenic stimulation on TBL location and activity using a germ-free (GF) newborn pig model, in which maternal antibodies and antigens do not affect B-cell development. Immunohistological analysis showed that TBL were disseminated mainly in the thymic medulla. There were no differences in the distribution of TBL, both in GF newborn piglets before and after colonization with Escherichia coli and in older conventionally reared (CONV) piglets. The number of immunoglobulin (Ig)-secreting cells measured by the ELISPOT method was not influenced by microflora and food antigens. IgM-positive cells secreting IgM and CD45RC-positive cells spontaneously producing IgM, IgG, and IgA were detected in newborn thymus. Our findings suggest that TBL differentiation and Ig switching to IgG and IgA-secreting cells is not influenced by external antigens and that the thymic microenvironment plays an important role in this process.     

Alternative Method of Solution of the Regulator Equation: L2‐Space Approach

An alternative method for the proof of solvability of the differential equation that is a part of the regulator equation which arises from the solution of the output regulation problem. The proof uses the L²‐space based theory of solutions of partial differential equations for the case of the linear output regulation problem. In the nonlinear case, a sequence of linear equations is defined so that their solutions converge to the solution of the nonlinear problem. This is proved using the Banach Contraction Theorem. Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society     

Hydrierende Vergasung von Kohle – Neuere Betriebsergebnisse

Hydrogasification of coal – recent operational results . The Rheinische Braunkohlenwerke AG has built and has been operating a semi-technical pilot plant for hydrogasification of coal in a fluidized bed. The objective is to develop a coal gasification process with hydrogen for producing directly substitute natural gas. Between 1976 and 1981, the semitechnical pilot plant having a capacity of 100 kg C/h was operated for about 22,900 h under test conditions, more than 9,500 h of which were under gasification conditions. During this time, approximately 1,400 metric tons of dry coal were gasified. The longest coherent operational phase under gasification conditions was 748 h in which 86.4 metric tons of dry lignite were gasified. Carbon gasification rates up to 82% and methane contents in the dry raw gas (free of N₂) up to 48 vol.-% were obtained. A detailed evaluation of the test results provided information on the influence of additional parameters on the efficiency dates of the gasifier and a considerable refining of the results obtained previously. Moreover, several components were tested for which no operational experience had previously been gained; these were newly developed devices, e. g. the inclined tube for feeding coal into the fluidized bed. Within the framework of scale-up work to large-scale coal gasification plants, a pilot plant having a capacity of approximately 6 t C/h will be commissioned in late 1982.     

Fluidized Bed Air Drying: Experimental Study and Model Development

The presented study describes the processes and mechanisms of batch fluidized bed drying. The influencing factors of hot air drying are theoretically and experimentally examined, in order to present the relations between temperature and humidity profiles and all other drying parameters. A physical model is presented to facilitate the calculation of the drying processes under defined conditions. Three succeeding drying stages are therefore modeled. Mass and energy balances including all components taking part in the process are formulated. The model clarities the drying process under the assumption of pure heat transfer mechanisms. It does not contain adaptive parameters and takes into account an inactive bypass fraction of the fluidization and drying medium. The evaluation of the model was successful for two fluidized bed plants with nominal widths of 100 mm and 400 mm. The experiments showed sufficient accuracy and transferability of the model to equipment of application‐oriented dimensions.     

Innovative User Interfaces in Automation Engineering by Application of Usability Engineering Methods Shown by the Example of a Three-Dimensional Plant Representation

This article is the first of 3 that focus on user-centered design and usability in the field of industrial process control. This article starts with an introduction to this special domain and sets out the need for user-centered design of innovative user interfaces. The MediaPlant research project is then introduced. This project aims to generate innovative user interface solutions for process control. The usability engineering methods presented are well known in relation to office application software and were applied in the course of the project to (a) evaluate the potential and application fields of innovative multimedia technology and 3-dimensional information presentation (described at the end of this article), (b) define innovative user interface building blocks for process control that can be applied across sectors (described in the second article, Komischke & Burmester [this issue]) and (c) develop human-centered user interfaces for controlling paper recycling plants (described in the third article, Epstein & Beu [this issue]).     

Autoimmunity, immunodeficiency and mucosal infections: chronic intestinal inflammation as a sensitive indicator of immunoregulatory defects in response to normal luminal microflora

Despite the fact that target antigens and the genetic basis of several autoimmune diseases are now better understood, the initial events leading to a loss of tolerance towards self-components remain unknown. One of the most attractive explanations for autoimmune phenomena involves various infections as possible natural events capable of initiating the process in genetically predisposed individuals. The most accepted explanation of how infection causes autoimmunity is based on the concept of "molecular mimicry" (similarity between the epitopes of an autoantigen and the epitopes in the environmental antigen). Infectious stimuli may also participate in the development of autoimmunity by inducing an increased expression of stress proteins (hsp), chaperones and transplantation antigens, which leads to abnormal processing and presentation of self antigens. Superantigens are considered to be one of the most effective bacterial components to induce inflammatory reactions and to take part in the development and course of autoimmune mechanisms. It has long been known that defects in the host defense mechanism render the individual susceptible to infections caused by certain microorganisms. Impaired exclusion of microbial antigens can lead to chronic immunological activation which can affect the tolerance to self components. Defects in certain components of the immune system are associated with a higher risk of a development of autoimmune disease. The use of animal models for the studies of human diseases with immunological pathogenesis has provided new insights into the influence of immunoregulatory factors and the lymphocyte subsets involved in the development of disease. One of the most striking conclusion arising from work with genetically engineered immunodeficient mouse models is the existence of a high level of redundancy of the components of the immune system. However, when genes encoding molecules involved in T cell immunoregulatory functions are deleted, spontaneous chronic inflammation of the gut mucosa (similar to human inflammatory bowel disease) develops. Surprisingly, when such immunocompromised animals were placed into germfree environment, intestinal inflammation did not develop. Impairment of the mucosal immune response to the normal bacterial flora has been proposed to play a crucial role in the pathogenesis of chronic intestinal inflammation. The use of immunodeficient models colonized with defined microflora for the analysis of immune reactivity will shed light on the mode of action of different immunologically important molecules responsible for the delicate balance between luminal commensals, nonspecific and specific components of the mucosal immune system.