Model-driven engineering for mobile robotic systems: a systematic mapping study

Software and Systems Modeling - Mobile robots operate in various environments (e.g. aquatic, aerial, or terrestrial), they come in many diverse shapes and they are increasingly becoming parts of...     

Tamquam alter idem: formal similarities in a subset of reports on anti-inflammatory compounds in the years 2008–2019

Scientometrics - A literature search on the in vitro testing of anti-inflammatory compounds of natural origin revealed a considerable number of studies adopting a similar template for data...     

Metabolism of phospholipids in the yeast Schizosaccharomyces pombe

The fission yeast Schizosaccharomyces pombe is an important model organism for the study of fundamental questions in eukaryotic cell and molecular biology. A plethora of cellular processes are membrane associated and/or dependent on the proper functioning of cellular membranes. Phospholipids are not only the basic building blocks of cellular membranes; they also serve as precursors to numerous signaling molecules. In this review, we describe the biosynthetic pathways leading to major S. pombe phospholipids, how these pathways are regulated, and what is known about degradation and turnover of fission yeast phospholipids. This review also addresses the synthesis, regulation and the role of water-soluble phospholipid precursors. The last chapter of the review is devoted to the use of S. pombe for the biotechnological production of value-added lipid molecules.     

Disorder Phenomena in Quantum Solids with Vacancies

Journal of Low Temperature Physics - We have investigated disorder phenomena in solid 4He near megting in presence of vacancies by means of Quantum Monte Carlo (MC) simulations using the Shadow...     

Non-pinched, minimum energy distillation designs

Non-pinched, minimum energy solutions are important class of distillation designs that offer the potential advantage of a better trade-off between capital investment and operating costs. In this paper, two important tasks associated with non-pinched distillation designs are studied. Thus the novel contributions of this work to the literature are

(1) A comprehensive methodology for finding non-pinched minimum energy designs.

(2) Understanding of the reasons for the existence of non-pinched distillation designs.

It is shown that the recent shortest stripping line distance approach of Lucia et al. [Lucia, A., Amale, A. and Taylor, R., 2007, Distillation pinch points and more. Comput Chem Eng, available on-line] is capable of systematically and reliably finding non-pinched, minimum energy distillation designs. In addition, we provide an understanding of the reasons behind the existence of non-pinched designs, which include trajectories that follow unstable branches of a pinch point curve in azeotropic systems, the inherent looping structure of trajectories in hydrocarbon separations, and the presence of ancillary constraints in multi-unit processes like extraction/distillation. Several distillation examples are studied and many numerical results and geometric illustrations are presented that show the shortest stripping line distance methodology is indeed a powerful and systematic tool for computing non-pinched, minimum energy designs and that support the underlying reason we provide for the existence of non-pinched designs.     

Mast cell and basophil development

In human esophageal cancers, no ras gene mutations but a relatively high prevalence of p53 gene mutations have been reported. We found a high prevalence of point mutations in Ha-ras and p53 genes in N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumors in two strains of rats (BD VI and F344). Our analysis showed the point mutation GGA-->GAA (expected from the known mechanisms of action of NMBA) at Ha-ras codon 12 in 22 of 46 (48%) and 22 of 38 (58%) papillomas from BD VI and F344 rats, respectively. There was no significant difference in the prevalence of ras mutations in tumors induced by high doses (5.0 mg/kg) and low doses (2.5 mg/kg) of NMBA. Eleven papillomas from each strain were analyzed for p53 mutations. The prevalent mutations found were G-->A and C-->T transitions. The frequency of p53 mutation was 36% (four of 11) for each strain. No apparent hot-spot codon or exon was found in the p53 gene, and two papillomas contained double mutations in this gene. The high prevalence of G-->A mutations in the rat Ha-ras gene contrasts with that in the human gene, in which no ras mutations have been found in primary tumors, and suggests either that the biology of esophageal carcinogenesis differs in humans and rats or that nitrosamines are not the major etiological risk factor for human esophageal cancers.     

Material constant sensitivity boundary integral equation for anisotropic solids

In this paper, the material constant sensitivity boundary integral equation is presented, and its numerical solution proposed, based on boundary element techniques. The formulation deals with plane problems with general rectilinear anisotropy. Expressions for the computation of sensitivities for displacements, tractions, strains and stresses are derived, both for boundary and interior points. The sensitivities can be computed with respect to the bulk material properties or to the properties of part of the domain (inclusions, coatings, etc.). To assess the accuracy of the proposed approach, the computed results are compared to analytical ones derived from exact solutions obtained by complex potential theory, when possible, or finite difference derivatives otherwise. Copyright © 2005 John Wiley & Sons, Ltd.     

A design methodology for networks of online modules and its application to the Levinson-Durbin algorithm

The use of online arithmetic was often proposed for hardware implementations of complex digital-signal processing (DSP) algorithms. However, several important issues in the design process of such algorithms using online arithmetic are rarely discussed in the literature. This paper presents these issues and provides a methodology to analyze the behavior of networks of online arithmetic modules performing serial computation over fixed-point numbers. The methodology is presented, applied in several examples, and finally used to design an efficient field programmable gate arrays implementation of the Levinson-Durbin algorithm in an application of the Yule-Walker power spectrum estimation. The methodology can be applied to other algorithms as well and it simplifies the task of designing and verifying a network of online modules. The experimental results show the advantages of online arithmetic in the design of complex DSP algorithms.