Paste Residence Time in a Spouted Bed Dryer. III: Effect of Paste Properties and Quality Interactions

The aim of this study was to evaluate the effects of paste properties on residence time during drying in a spouted bed dryer with inert bodies. The effect of paste solids content, surface tension, and viscosity on the residence time distribution and the mean residence times were studied using factorial experimental designs. The inert bodies used were glass and polyethylene beads. The mean residence times varied from 13.6 to 16.3 and 12.2 to 17.7 min for drying on glass and polyethylene beads, respectively. The analysis of variance showed that mean residence times significantly depended on solids content and surface tension for glass beads and also on viscosity for polyethylene beads. The residence time distributions for all conditions studied fitted well to the perfect mixing cell when applying the continuous stirred vessels in series model analysis. The powder density, flowability, and particle size depended on paste properties and inert type.     

Nisin expression production from Lactococcus lactis in milk whey medium

BACKGROUND: Nisin is a commercially available bacteriocin produced by Lactococcus lactis ATCC 11454 and used as a natural agent in the biopreservation of food. In the current investigation, milk whey, a byproduct from dairy industries was used as a fermentation substrate for the production of nisin. Lactococcus lactis ATCC 11454 was developed in a rotary shaker (30 °C/36 h/100 rpm) using two different media with milk whey (i) without filtration, pH 6.8, adjusted with NaOH 2 mol L^?1 and without pH adjustment, both autoclaved at 121 °C for 30 min, and (ii) filtrated (1.20 µm and 0.22 µm membrane filter). These cultures were transferred five times using 5 mL aliquots of broth culture for every new volume of the respective media. RESULTS: The results showed that culture media composed of milk whey without filtration supplied L. lactis its adaptation needs better than filtrated milk whey. Nisin titers, in milk whey without filtration (pH adjusted), was 11120.13 mg L^?1 in the second transfer, and up to 1628‐fold higher than the filtrated milk whey, 6.83 mg.L^?1 obtained in the first^t transfer. CONCLUSIONS: Biological processing of milk byproducts (milk whey) can be considered a profitable alternative, generating high‐value bioproducts and contributing to decreasing river disposals by dairy industries. Copyright © 2008 Society of Chemical Industry     

A Survey of Service Discovery Protocols in Multihop Mobile Ad Hoc Networks

An in-depth review of service discovery protocols (SDPs) in multihop mobile ad hoc networks analyzes SDP building blocks and determines SDP suitability based on architecture, mobility, and network size. Mobile ad hoc networks (manets) include a variety of devices, such as cell phones, PDAs, laptops, and other relatively larger devices. These devices can move at high or low speeds or even remain stationary, entering and leaving the system when switched on or off. Such a variety of devices also offers a variety of services. A service is any tangible or intangible facility a device provides that can be useful for any other device. Services comprise those for software and hardware. A software service, for example, can be a simple file, such as an MP3 file, or a software implementation of an algorithm, such as converting one audio file format to another. A hardware service, for example, can be a printer that a mobile device can use wirelessly. To benefit from these services, a device must be able to both locate them in the network and invoke them. Service discovery protocols (SDPs) enable these capabilities.     

A class of high performance Maekawa-type algorithms for distributed systems under heavy demand

Summary Distributed Mutual Exclusion algorithms have been mainly compared using the number of messages exchanged per critical section execution. In such algorithms, no attention has been paid to the serialization order of the requests. Indeed, they adopt FCFS discipline. Conversely, the insertion of priority serialization disciplines, such as Short-Job-First, Head-Of-Line, Shortest-Remaining-Job-First etc., can be useful in many applications to optimize some performance indices. However, such priority disciplines are prone to starvation. The goal of this paper is to investigate and evaluate the impact of the insertion of a priority discipline in Maekawa-type algorithms. Priority serialization disciplines will be inserted by means of agated batch mechanism which avoids starvation. In a distributed algorithm, such a mechanism needs synchronizations among the processes. In order to highlight the usefulness of the priority based serialization discipline, we show how it can be used to improve theaverage response time compared to the FCFS discipline. The gated batch approach exhibits other advantages: algorithms are inherently deadlock-free and messages do not need to piggyback timestamps. We also show that, under heavy demand, algorithms using gated batch exchange less messages than Maekawa-type algorithms per critical section excution. Roberto Baldoni was born in Rome on February 1, 1965. He received the Laurea degree in electronic engineering in 1990 from the University of Rome La Sapienza and the Ph.D. degree in Computer Science from the University of Rome La Sapienza in 1994. Currently, he is a researcher in computer science at IRISA, Rennes (France). His research interests include operating systems, distributed algorithms, network protocols and real-time multimedia applications. Bruno Ciciani received the Laurea degree in electronic engineering in 1980 from the University of Rome La Sapienza. From 1983 to 1991 he has been a researcher at the University of Rome Tor Vergata. He is currently full professor in Computer Science at the University of Rome La Sapienza. His research activities include distributed computer systems, fault-tolerant computing, languages for parallel processing, and computer system performance and reliability evaluation. He has published in IEEE Trans. on Computers, IEEE Trans. on Knowledge and Data Engineering, IEEE Trans. on Software Engineering and IEEE Trans. on Reliability. He is the author of a book titled Manufactoring Yield Evaluation of VLSI/WSI Systems to be published by IEEE Computer Society Press.This research was supported in part by the Consiglio Nazionale delle Ricerche under grant 93.02294.CT12This author is also supported by a grant of the Human Capital and Mobility project of the European Community under contract No. 3702 CABERNET     

A biased random‐key genetic algorithm for OSPF and DEFT routing to minimize network congestion

Interior gateway routing protocols like Open Shortest Path First (OSPF) and Distributed Exponentially Weighted Flow Splitting (DEFT) send flow through forward links toward the destination node. OSPF routes only on shortest‐weight paths, whereas DEFT sends flow on all forward links, but with an exponential penalty on longer paths. Finding suitable weights for these protocols is known as the weight setting problem (WSP). In this paper, we present a biased random‐key genetic algorithm for WSP using both protocols. The algorithm uses dynamic flow and dynamic shortest path computations. We report computational experiments that show that DEFT achieves less network congestion when compared with OSPF, while, however, yielding larger delays.     

The between-day and inter-rater reliability of a novel wireless system to analyse lumbar spine posture

Lumbar posture is commonly assessed in non-specific chronic low back pain (NSCLBP), although quantitative measures have mostly been limited to laboratory environments. The BodyGuard? is a spinal position monitoring device that can monitor posture in real time, both inside and outside the laboratory. The reliability of this wireless device was examined in 18 healthy participants during usual sitting and forward bending, two tasks that are commonly provocative in NSCLBP. Reliability was determined using intraclass correlation coefficients (ICC), the standard error of measurement (SEM), the mean difference and the minimal detectable change (MDC90). Between-day ICC values ranged from 0.84 to 0.87, with small SEM (5%), mean difference (<9%) and MDC90 (<14%) values. Inter-rater ICC values ranged from 0.91 to 0.94, with small SEM (4%), mean difference (6%) and MDC90 (9%) values. Between-day and inter-rater reliability are essential requirements for clinical utility and were excellent in this study. Further studies into the validity of this device and its application in clinical trials in occupational settings are required. STATEMENT OF RELEVANCE: A novel device that can analyse spinal posture exposure in occupational settings in a minimally invasive manner has been developed. This study established that the device has excellent between-day and inter-rater reliability in healthy pain-free subjects. Further studies in people with low back pain are planned.     

Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment

Glioblastoma multiforme is a lethal disease and represents the most common and severe type of glioma. Drug resistance and the evasion of cell death are the main characteristics of its malignancy, leading to a high percentage of disease recurrence and the patients’ low survival rate. Exploiting the modulation of cell death mechanisms could be an important strategy to prevent tumor development and reverse the high mortality and morbidity rates in glioblastoma patients. Ferroptosis is a recently described type of cell death, which is characterized by iron accumulation, high levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, and deficiency in lipid peroxidation repair. Several studies have demonstrated that ferroptosis has a potential role in cancer treatment and could be a promising approach for glioblastoma patients. Thus, here, we present an overview of the mechanisms of the iron-dependent cell death and summarize the current findings of ferroptosis modulation on glioblastoma including its non-canonical pathway. Moreover, we focused on new ferroptosis-inducing compounds for glioma treatment, and we highlight the key ferroptosis-related genes to glioma prognosis, which could be further explored. Thereby, understanding how to trigger ferroptosis in glioblastoma may provide promising pharmacological targets and indicate new therapeutic approaches to increase the survival of glioblastoma patients.     

Multivariate data analysis of some xenobiotic trace metals in mussels from the Gulf of Trieste

Summary The concentration of Cd, Hg and Pb in the soft part of mussels has been studied by means of bi-and multi-variate statistical approaches. In particular, the principal component analysis has been applied to study the association among these toxic metals in mussels sampled from the gulf of Trieste, which is a critical area as far as mercury pollution is concerned.

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Mehrdimensionale Analyse der Daten einiger xenobiotischer Spurenmetalle in Miesmuscheln aus dem Golf von Triest

Zusammenfassung Der Gehalt von Cd, Hg und Pb in Miesmuschelfleisch wurde nach einer statistischen mehrdimensionalen Analyse untersucht. Besonders wurde die Hauptkomponentenanalyse zum Studium der Assoziationen dieser toxischen Metalle in Miesmuscheln angewandt. Die Miesmuschelproben stammten aus dem Golf von Triest, ein kritisches Gebiet für Quecksilberverunreinigungen.