Estimating the altitude of aerosol plumes over the ocean from reflectance ratio measurements in the O2 A-band

A methodology is proposed to infer the altitude of aerosol plumes over the ocean from reflectance ratio measurements in the O₂ absorption A-band (759 to 770 nm). The reflectance ratio is defined as the ratio of the reflectance in a first spectral band, strongly attenuated by O₂ absorption, and the reflectance in a second spectral band, minimally attenuated. For a given surface reflectance, simple relations are established between the reflectance ratio and the altitude of an aerosol layer, as a function of atmospheric conditions and the geometry of observation. The expected accuracy for various aerosol loadings and models is first quantified using an accurate, high spectral resolution, radiative transfer model that fully accounts for interactions between scattering and absorption. The method is developed for POLDER and MERIS, satellite sensors with adequate spectral characteristics. The simulations show that the method is only accurate over dark surfaces when aerosol optical thickness at 765 nm is relatively large (> 0.3). In this case, the expected accuracy is on the order of ± 0.5 km or ± 0.2 km for POLDER or MERIS respectively. More accurate estimates are obtained with MERIS, since in this case the spectral reflectance ratio is more sensitive to aerosol altitude. However, a precise spectral calibration is needed for MERIS. The methodology is applied to MERIS and POLDER imagery acquired over marine surfaces. The estimated aerosol altitude is compared with in situ lidar profiles of backscattering coefficient measured during the AOPEX-2004 experiment for MERIS, or obtained with the space-borne lidar CALIOP for POLDER. The retrieved altitudes agree with lidar measurements in a manner consistent with theory. These comparisons demonstrate the potential of the differential absorption methodology for obtaining information on aerosol altitude over dark surfaces.     

Network-centric music performance: practice and experiments

Advances in information technology and the great proliferation of the Internet have changed nearly every aspect of the work and life of human beings. Despite progress in networked entertainment, many music professionals and enthusiasts are still sticking to the traditional way of carrying out rehearsals and concerts. Music performance in this way requires physical presence of the participants and has a number of inherent limitations. We introduce a novel system called network-centric music performance (NMP) that enables multiparty music performance through cyberspace. Our target is to support real-time multichannel natural audio streaming over the network, using audio compression schemes that can provide acceptable audio quality. A system like this is bandwidth-demanding and highly delay-sensitive, and requires synchronization of the audio streams. Hence, support from the underlying end systems and networks is critical. However, the current source coding mechanisms and the best effort nature of the internet pose many challenges to achieve the desired quality of service. We have implemented a prototype of NMP, and exploited end system and network influences on NMP. The work was done in a LAN environment using Linux PCs. The system enables two different application scenarios: real-time rehearsal and rehearsal on demand. Real-time multichannel audio transport and different audio compression schemes are supported. Our evaluation results based on both subjective and objective measurements show that the system provides sufficient audio quality level for the target application in such an environment. The scalability test also revealed that the system scales well with increase of clientele. In the future, we extend our system for networks spanning larger distances and experiment with more realistic network conditions in the Internet.     

Aryl Bis‐Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum

2‐Methylerythritol 2,4‐cyclodiphosphate synthase (IspF) is an essential enzyme for the biosynthesis of isoprenoid precursors in plants and many human pathogens. The protein is an attractive target for the development of anti‐infectives and herbicides. Using a photometric assay, a screen of 40 000 compounds on IspF from Arabidopsis thaliana afforded symmetrical aryl bis‐sulfonamides that inhibit IspF from A. thaliana (AtIspF) and Plasmodium falciparum (PfIspF) with IC₅₀ values in the micromolar range. The ortho‐bis‐sulfonamide structural motif is essential for inhibitory activity. The best derivatives obtained by parallel synthesis showed IC₅₀ values of 1.4 μm against PfIspF and 240 nm against AtIspF. Substantial herbicidal activity was observed at a dose of 2 kg ha^?1. Molecular modeling studies served as the basis for an in silico search targeted at the discovery of novel, non‐symmetrical sulfonamide IspF inhibitors. The designed compounds were found to exhibit inhibitory activities in the double‐digit micromolar IC₅₀ range.     

Combinatorial auctions for exchanging resources over a grid network

In grid systems, users compete for different types of resources such that they may execute their applications. Traditional grid systems are formed of organisations that join together for the purpose of collaborative projects. Resources of each of the participating organisation are pooled such that members of individual organisations may access the shared infrastructure. In general, each participant is both a provider and a consumer of resources. Whilst such systems address large organisations, in this paper we address democratic grid systems to satisfy needs of small organisations and even individuals, where on-demand grids may be formed by drawing idling resources available on the Internet. Whilst traditional grid systems resort to allocations that satisfy system specific objectives such as maximization of the resource utilisation, market mechanisms try to obtain allocations that are efficient economically. Economic mechanisms permit to achieve equilibrium between supply and demand and furthermore provide incentives for providers. Combinatorial auction has been argued as an effective mechanism to address the problem of resource allocation within grid systems. Auctions within which multiple types of resources in varying quantities may be traded eliminate the exposure problem by addressing co-allocation. In this paper, we describe a combinatorial exchange where multiple providers and multiple consumers may participate. We describe the winner determination problem that incorporates the time dimension, i.e. resource bundles may be requested for different time ranges, and describe a set of heuristics that have been designed to be fast. We show that these achieve a high level of efficiency as compared to exact solutions. The second part focusses on the pricing problem. The objective is to compute prices that represent the state of the market and bring trustworthy feedback to participants. Drawing on the approach taken by Kwasnica et al. (Manage Sci 51(3):419–434, 2005), we propose a pricing model that computes per-item pricing. Per-item pricing allows users to deduce the price of bundles that they require by linear summation. Furthermore, we propose a model that computes prices as a function of time, thus permitting users, in particular consumers to adjust their demand trading off price and time of execution.     

Transparent polycrystalline alumina obtained by SPS: Green bodies processing effect

Starting from a commercial slurry of high purity α-Al₂O₃, freeze-dried powders, cast, filter-pressed or cold isostatically pressed samples were produced. Resulting powders or green bodies showing different particles packing were densified by spark plasma sintering (SPS) to obtain transparent polycrystalline α-Al₂O₃. Microstructure and real in-line transmittance (RIT) after SPS were dependent on the particles packing quality. Avoiding large agglomerates, narrowing the pore size distribution, reducing the most-frequent pore size (D_mode) and avoiding macroscopic heterogeneities within the green bodies enabled high RIT values to be achieved in the visible and near-infrared spectrum. However, a limit was achieved in the preparation of green bodies for which reducing the D_mode had no more influence on the optical behaviour of samples sintered by SPS. Finally, pure α-Al₂O₃ samples presenting a high RIT_640 nm value of 53% were produced from all the green bodies obtained by the following techniques: filter-pressing, slip casting and cold isostatic pressing.     

Lung cancer mortality in a French cohort of hard-metal workers

A cohort mortality study was carried out among workers of a plant producing hard metals using cobalt as a binder. This study was aimed at assessing possible lung cancer risks in relation with cobalt exposure. Seven hundred nine male workers with at least 1 year of employment were included in the cohort and followed for mortality from 1956 to 1989. Job histories were provided by the administration of the plant, whereas smoking habits were collected from medical records and by interview. The causes of deaths were ascertained from hospital and general practitioner records. The observed numbers of deaths (obs) were compared with the expected based on national rates with adjustment for age, sex, and calendar time (standardized mortality ratio; SMR). The overall mortality did not differ from that expected (obs = 75, SMR = 1.05), whereas mortality due to lung cancer was in significant excess (obs = 10, SMR = 2.13). This excess was higher among workers employed in the areas with the highest exposure (obs = 6, SMR = 5.03). No trend was observed, however, with duration of employment or time since first employment. Smoking data were available for 81% of the workers and 69% of the deceased and showed that smoking alone does not account for these lung cancer excesses, yet, because of the small numbers involved, no firm conclusion should be drawn from this study.     

Production of short-chain fatty acids from resistant starch in a pig model

This study was performed to estimate the pool of SCFA produced in the digestive tract of growing pigs after the consumption of diets containing dif-ferent sources of resistant starch (RS) (15 g per meal) (potato starch (PoS), high amylose maize starch (HS) and retrograded extruded HS (RHS)). SCFA production in vitro was respectively 19, 23 and 21 mmol g⁻¹ of fermented PoS, HS and RHS. The highest butyric acid production was observed with PoS. Fifty six, 36 and 19% respectively of ingested PoS, HS and RHS escaped digestion in the small intestine, whereas residual starch was completely fermented in the large bowel. Luminal total SCFA in the caeco-colon 7 h after the experimental meal were respectively 33, 78 and 105 mmol for PoS, HS and RHS, with PoS providing the highest production of butyric acid. Theoretical in vivo SCFA production, calculated on the basis of results for in vitro fermentation and ileal digestibility, differed from in vivo results for PoS (+65%) and HS (-13%), but not for RHS. This study reveals different rates of disappearance of RS both in vitro and in vivo. © 1998 SCI.     

Contact formation dynamics: Mapping chemical bond formation between a molecule and a metallic probe

We present a study that maps out chemical bond formation between a Pt-inked probe and a single 1,3-cyclohexadiene (1,3-CHD) molecule on Si(100). By separating the mechanical and electronic contributions to the current during the approach to contact, we show that there are significant forces between the probe and the C=C of the molecule and we track the relaxation of the molecule, the emergence of a chemical bond feature in the LDOS, and the quenching of specific molecular vibrations during bond formation.     

Prion degradation in soil: possible role of microbial enzymes stimulated by the decomposition of buried carcasses

This study is part of a European project focused on understanding the biotic and abiotic mechanisms involved in the retention and dissemination of transmissible spongiform encephalopathies (TSE) infectivity in soil in order to propose practical recommendations to limit environmental contamination. A 1-year field experiment was conducted with lamb carcasses buried in a pasture soil at three depths (25, 45, and 105 cm). Microbial community response to carcasses was monitored through the potential proteolytic activity and substrate induced respiration (SIR). Soil above carcasses and control soil exhibited low proteolytic capacity, whatever the depth of burial. Contrastingly, in soil beneath the carcasses, proteolysis was stimulated. Decomposing carcasses also stimulated SIR, i.e., microbial biomass, suggesting that proteolytic populations specifically developed on lixiviates from animal tissues. Decomposition of soft tissues occurred within 2 months at subsurface while it lasted at least 1 year at deeper depth where proteolytic activities were season-dependent. The ability of soil proteases to degrade the beta form of prion protein was shown in vitro and conditions of burial relevant to minimize the risk of prion protein dissemination are discussed.