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HH Henneicke-von Zepelin U Mrowietz L F?rber K Bruck-Borchers C Schober J Huber G Lutz R Kohnen E Christophers D Welzel 《Canadian Metallurgical Quarterly》1993,129(6):713-717
We report the results of a multicentre, double-blind, placebo-controlled study of topical therapy with omega-3-polyunsaturated fatty acids (omega-3-PUFA) in 52 patients suffering from moderate plaque-type psoriasis. In each patient, two similar stable psoriatic plaques served as indicator lesions for the study. One indicator lesion was randomly assigned to treatment with topical preparations of highly purified omega-3-PUFA in one of two concentrations (1 or 10%), and the other was treated with placebo. Efficacy assessment was based on changes in local psoriasis severity index, area involved, erythema, desquamation, induration and pruritus. After 8 weeks of treatment, all indicator lesions had improved significantly, compared with baseline. However, no statistically or clinically relevant differences between the omega-3-PUFA-treated and the placebo-treated lesions were found. Therapy was well tolerated and, apart from one patient who developed perilesional eczema, no clinically relevant adverse events occurred. In conclusion, topical omega-3-PUFA were not effective in a randomized, placebo-controlled, double-blind setting. Results of non-blind trials should be (re-)considered with caution. 相似文献
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In node-positive breast carcinoma, the presence of tumour cells in the efferent vessels (EV) of the axillary nodes (positive EV status) was shown to be of poor prognosis in 1979. Later the presence of nodal micrometastases was also related to survival. This report describes a new subgroup in this system that is of potential therapeutic interest. It consisted of the 40% of the EV-positive cases with micrometastases (< 0.2 cm2) in their nodes, in addition to nodes with macrometastases. In them the difference in prognosis associated with EV status no longer held. Their prognosis did not differ markedly from that in the EV-negative patients. In the absence of such 'additional' micrometastases, the prognostic difference was still highly significant. There was also some indication that the presence of micrometastases consisting of embolic tumour growth alone may be associated with early death in EV-negative cases, in keeping with the prognosis in cases with lone micrometastases. 相似文献
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掺铒光纤放大器(EDFA)的烧孔效应(SHB)是导致放大器增益不平坦主要因素,进而影响长距离波分复用(wDM)光纤传输系统的性能。与此同时,对于EDFA的非均匀加宽作用的物理学研究并不成熟,所提出的几个理论模型也只是从经验和统计方面对SHB在一定程度上进行分析。为此,我们首次提出了利用放大器恒定增益控制来研究SHB的实验方法,分析了室温下1530~1564nm波长范围内SHB的深度、宽度与饱和信号波长的关系,以及SHB的深度与饱和信号功率的关系。 相似文献
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This presidential column announces the significant internal changes of Division 13 of the Consulting Psychology Journal. The journal is now published by the Educational Publishing Foundation, which is associated with the American Psychological Association in order to increase the quality, quantity, and diversity of submissions to the journal. The author outlines the steps that will be taken to make the Division a more viable and inviting organization for members in ways that are obvious and easily accessible to them. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Ohne Zusammenfassung 相似文献
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Ekkehard H. Lutz 《Journal of the American Ceramic Society》1994,77(5):1274-1280
Plasma spraying, originally a surfacing technology used for ceramic coating of metal and nonmetal substrates, is suitable for producing large, full ceramic bodies, such as plates and tubes, in situ to almost the desired dimensions; i.e., conventional methods of designing by molding and casting green bodies followed by sintering are not required. These "plasma ceramics" exhibit characteristic mechanical and thermomechanical properties. Their porous laminar grain structure results in low E -modulus and strength, and in extreme thermal shock resistance, which is enhanced by the comparably high fracture resistance of the material. Because of these properties and their low hardness, plasma ceramics can be easily machined with almost conventional methods of metal processing. 相似文献
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