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1.
Anna Sztaniszlav Magdolna Balla Maria Farkas-Jahnke Csaba Novák 《Journal of Materials Science》1990,25(5):2353-2358
The kinetics of solid-state reactions of powdered reactants were investigated by X-ray and by differential thermogravimetry in a magnetic field. Measurements revealed mutual diffusion of the Fe3+ and In3+ ions in the Fe2O3-In2O3 system heat treated for 3 h at 700 to 1400° C. Diffusion of indium into the Fe2O3 lattice caused a shift of the Curie temperature of the antiferromagnetic iron oxide towards lower temperatures. Only Caln2O4 was found between CaCO3 and In2O3 up to 1400° C. Also, in the Fe2O3-CaCO3-In2O3in system, the reaction started with the mutual diffusion of iron and indium and the forming of CaFe2O4. End-products were the magnetic -Ca4Fe14O25 and CaFe4O7, and the non-magnetic CaFe5O7, depending on the In3+ concentration. Indium stabilized the magnetic calcium-iron oxide structures, shifting their Curie temperatures towards lower values. 相似文献
2.
Eva Kiss Gertrud Forika Reka Mohacsi Zsuzsanna Nemeth Tibor Krenacs Magdolna Dank 《International journal of molecular sciences》2021,22(7)
Dietary methyl-donors play important roles in physiological processes catalyzed by B vitamins as coenzymes, and are used for complementary support in oncotherapy. Our hypothesis was that methyl-donors can not only assist in tolerating cancer treatment but may also directly interfere with tumor growth and proliferation. Therefore, we investigated the proposed cancer inhibitory effects of methyl-donors (in a mixture of L-methionine, choline chloride, folic acid, and vitamin B12) on MCF7 and T47D breast cancer as well as A549 and H1650 lung cancer cell lines. Indeed, methyl-donor treatment significantly reduced the proliferation in all cell lines, possibly through the downregulation of MAPK/ERK and AKT signaling. These were accompanied by the upregulation of the pro-apoptotic Bak and Bax, both in MCF7 and H1650 cells, at reduced anti-apoptotic Mcl-1 and Bcl-2 levels in MCF7 and H1650 cells, respectively. The treatment-induced downregulation of p-p53(Thr55) was likely to contribute to protecting the nuclear localization and apoptosis inducing functions of p53. The presented features are known to improve the sensitivity of cancer therapy. Therefore, these data support the hypothesis, i.e., that methyl-donors may promote apoptotic signaling by protecting p53 functions through downregulating both the MAPK/ERK and the AKT pathways both in breast and lung adenocarcinoma cell lines. Our results can emphasize the importance and benefits of the appropriate dietary supports in cancer treatments. However, further studies are required to confirm these effects without any adverse outcome in clinical settings. 相似文献
3.
N. Blaunstein Z. Dank M. Zilbershtein 《Subsurface Sensing Technologies and Applications》2000,1(1):79-99
Theoretical and experimental investigations of the radiation properties of a buried leaky coaxial cable (LCC), as a guarding radar system, are presented for various artificial and natural local inhomogeneous conditions along the cable system. The theoretical model of two coupling coaxial lines, outside of which consists of a sub-soil medium, is introduced to describe interactions of two modes, external and internal, which determine the working characteristics of such a leaky coaxial cable. The vertical and the horizontal distribution of radiation along and across the cable at height h above the ground are examined experimentally by means of a loop of the LCC buried in the sub-soil medium. A comparison between experimental data and theoretical predictions of radiation directivity of the LCC for the guarding radar system is presented. The possibilities of generating a complicated interference picture of such a radar pattern caused by different kinds of local inhomogeneities are discussed theoretically and studied experimentally. 相似文献
4.
Miklós Pogány Tamás Dankó Evelin Kámán-Tóth Ildikó Schwarczinger Zoltán Bozsó 《International journal of molecular sciences》2015,16(10):23177-23194
Approximately two and a half percent of protein coding genes in Arabidopsis encode enzymes with known or putative proteolytic activity. Proteases possess not only common housekeeping functions by recycling nonfunctional proteins. By irreversibly cleaving other proteins, they regulate crucial developmental processes and control responses to environmental changes. Regulatory proteolysis is also indispensable in interactions between plants and their microbial pathogens. Proteolytic cleavage is simultaneously used both by plant cells, to recognize and inactivate invading pathogens, and by microbes, to overcome the immune system of the plant and successfully colonize host cells. In this review, we present available results on the group of proteases in the model plant Arabidopsis thaliana whose functions in microbial pathogenesis were confirmed. Pathogen-derived proteolytic factors are also discussed when they are involved in the cleavage of host metabolites. Considering the wealth of review papers available in the field of the ubiquitin-26S proteasome system results on the ubiquitin cascade are not presented. Arabidopsis and its pathogens are conferred with abundant sets of proteases. This review compiles a list of those that are apparently involved in an interaction between the plant and its pathogens, also presenting their molecular partners when available. 相似文献
5.
Mesoporous Ti-MCM-41 materials as photodegradation catalysts of 2,4,6-trichlorophenol in water 总被引:1,自引:0,他引:1
Ahmed?K.?Aboul-Gheit Sohair?M.?Abdel-Hamid Sawsan?A.?Mahmoud Radwa?A.?El-Salamony József?Valyon Magdolna?R.?Mihályi ágnes?SzegediEmail author 《Journal of Materials Science》2011,46(10):3319-3329
Titanium-modified MCM-41 type mesoporous silica materials were prepared by hydrothermal [Ti-MCM-41(HT)], sol–gel [Ti-MCM-41(SG)]
and post-synthesis impregnation [TiO2/MCM-41] methods. The materials were characterized and tested as photocatalysts in the oxidative degradation reaction of 2,4,6-trichlorophenol
(2,4,6-TCP) in water. The catalysts showed high initial activity. The produced acetate and chloride ions were found to inhibit
the degradation reaction. The Ti-MCM-41(HT) sample showed higher overall activity than the Ti-MCM-41(SG) catalyst. One of
the probable reasons for this is the difference in the distribution of the active sites that determines the rates of electron
(e−)–hole (h+) recombination within the photoactive species. The HT preparation was found to contain silica-bound titania in higher dispersion,
while the SG preparation contained also polymerized species with Ti–O–Ti bonds. 相似文献
6.
Evaluation of quality of kefir from milk obtained from goats supplemented with a diet rich in bioactive compounds 下载免费PDF全文
7.
Barbara Kinga Bartk Tams Fodor Alexandra Kalmr Zsfia Brigitta Nagy Sra Zsigrai Krisztina Andrea Szigeti Gbor Valcz Pter Igaz Magdolna Dank Istvn Takcs Bla Molnr 《International journal of molecular sciences》2022,23(7)
Monitoring the therapeutic response of colorectal cancer (CRC) patients is crucial to determine treatment strategies; therefore, we constructed a liquid biopsy-based approach for tracking tumor dynamics in non-metastatic (nmCRC) and metastatic (mCRC) patients (n = 55). Serial blood collections were performed during chemotherapy for measuring the amount and the global methylation pattern of cell-free DNA (cfDNA), the promoter methylation of SFRP2 and SDC2 genes, and the plasma homocysteine level. The average cfDNA amount was higher (p < 0.05) in nmCRC patients with recurrent cancer (30.4 ± 17.6 ng) and mCRC patients with progressive disease (PD) (44.3 ± 34.5 ng) compared to individuals with remission (13.2 ± 10.0 ng) or stable disease (12.5 ± 3.4 ng). More than 10% elevation of cfDNA from first to last sample collection was detected in all recurrent cases and 92% of PD patients, while a decrease was observed in most patients with remission. Global methylation level changes indicated a decline (75.5 ± 3.4% vs. 68.2 ± 8.4%), while the promoter methylation of SFRP2 and SDC2 and homocysteine level (10.9 ± 3.4 µmol/L vs. 13.7 ± 4.3 µmol/L) presented an increase in PD patients. In contrast, we found exact opposite changes in remission cases. Our study offers a more precise blood-based approach to monitor the treatment response to different chemotherapies than the currently used markers. 相似文献
8.
9.
Bodnár M Kjøniksen AL Molnár RM Hartmann JF Daróczi L Nyström B Borbély J 《Journal of hazardous materials》2008,153(3):1185-1192
The present investigation describes the preparation and characterization of novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (gamma-PGA) with bivalent lead ion. The prepared nano-systems were stable in aqueous media at low pH, neutral and mild alkaline conditions. The particle size and the size of the complexes were identified by dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements. It was found that the size of the complexes depended on the pH and concentrations of gamma-PGA and lead ions. Particle sizes measured by TEM revealed that at low concentrations, nanosized particles were formed, however, at high concentrations of gamma-PGA and lead ions, the formation of large aggregates with a broad size distribution was promoted. The size of individual particles was in the range of 40-100 nm measured by TEM. The results from the DLS measurements showed that the low and high pH values in mixtures with high concentrations of gamma-PGA and Pb2+ ions favored the growth of large complexes. The gamma-PGA nanoparticles, composed of a biodegradable biomaterial with high flocculating and heavy metal binding activity, may be useful for various water treatment applications. 相似文献
10.
Magdolna Csvs Lszl Kalmr Petronella Szke Lszl Bence Farkas Blint Bcsi Zoltn Knya Jnos Kerkgyrt Anik Borbs Ferenc Erddi Katalin E. Kvr 《International journal of molecular sciences》2022,23(24)
The Gram-negative bacterium Pseudomonas aeruginosa is an important opportunistic human pathogen associated with cystic fibrosis. P. aeruginosa produces two soluble lectins, the d-galactose-specific lectin PA-IL (LecA) and the l-fucose-specific lectin PA-IIL (LecB), among other virulence factors. These lectins play an important role in the adhesion to host cells and biofilm formation. Moreover, PA-IL is cytotoxic to respiratory cells in the primary culture. Therefore, these lectins are promising therapeutic targets. Specifically, carbohydrate-based compounds could inhibit their activity. In the present work, a 3-O-fucosyl lactose-containing tetravalent glycocluster was synthesized and utilized as a mutual ligand of galactophilic and fucophilic lectins. Pentaerythritol equipped with azido ethylene glycol-linkers was chosen as a multivalent scaffold and the glycocluster was constructed by coupling the scaffold with propargyl 3-O-fucosyl lactoside using an azide-alkyne 1,3-dipolar cycloaddition reaction. The interactions between the glycocluster and PA-IL or PA-IIL were investigated by isothermal titration microcalorimetry and saturation transfer difference NMR spectroscopy. These results may assist in the development of efficient anti-adhesion therapy for the treatment of a P. aeruginosa infection. 相似文献