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排序方式: 共有148条查询结果,搜索用时 10 毫秒
1.
Shoji Seki Mami Iwasaki Hiroto Makino Yasuhito Yahara Miho Kondo Katsuhiko Kamei Hayato Futakawa Makiko Nogami Kenta Watanabe Nguyen Tran Canh Tung Tatsuro Hirokawa Mamiko Tsuji Yoshiharu Kawaguchi 《International journal of molecular sciences》2022,23(9)
The role of the ligamentum flavum (LF) in the pathogenesis of adolescent idiopathic scoliosis (AIS) is not well understood. Using magnetic resonance imaging (MRI), we investigated the degrees of LF hypertrophy in 18 patients without scoliosis and on the convex and concave sides of the apex of the curvature in 22 patients with AIS. Next, gene expression was compared among neutral vertebral LF and LF on the convex and concave sides of the apex of the curvature in patients with AIS. Histological and microarray analyses of the LF were compared among neutral vertebrae (control) and the LF on the apex of the curvatures. The mean area of LF in the without scoliosis, apical concave, and convex with scoliosis groups was 10.5, 13.5, and 20.3 mm2, respectively. There were significant differences among the three groups (p < 0.05). Histological analysis showed that the ratio of fibers (Collagen/Elastic) was significantly increased on the convex side compared to the concave side (p < 0.05). Microarray analysis showed that ERC2 and MAFB showed significantly increased gene expression on the convex side compared with those of the concave side and the neutral vertebral LF cells. These genes were significantly associated with increased expression of collagen by LF cells (p < 0.05). LF hypertrophy was identified in scoliosis patients, and the convex side was significantly more hypertrophic than that of the concave side. ERC2 and MAFB genes were associated with LF hypertrophy in patients with AIS. These phenomena are likely to be associated with the progression of scoliosis. 相似文献
2.
Mami Ogimoto Kumi Suzuki Nahoko Haneishi Yuu Kikuchi Mayu Takanashi Naoko Tomioka 《Food Additives and Contaminants: Part B: Surveillance Communications》2016,9(3):185-190
Aluminium (Al) levels of 90 food samples were investigated. Nineteen samples contained Al levels exceeding the tolerable weekly intake (TWI) for young children [body weight (bw): 16 kg] when consuming two servings/week. These samples were purchased multiple times at specific intervals and were evaluated for Al levels. Al was detected in 27 of the 90 samples at levels ranging from 0.01 (limit of quantitation) to 1.06 mg/g. Of these, the Al intake levels in two samples (cookie and scone mix, 1.3 and 2 mg/kg bw/week, respectively) exceeded the TWI as established by European Food Safety Authority, although the level in the scone mix was equivalent to the provisional TWI (PTWI) as established by Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Committee on Food Additives. The Al levels markedly decreased in 14 of the 19 samples with initially high Al levels. These results indicated reductions in the Al levels to below the PTWI limits in all but two previously identified food samples. 相似文献
3.
Shoji Seki Mami Iwasaki Hiroto Makino Yasuhito Yahara Yoshitaka Miyazaki Katsuhiko Kamei Hayato Futakawa Makiko Nogami Nguyen Tran Canh Tung Tatsuro Hirokawa Mamiko Tsuji Yoshiharu Kawaguchi 《International journal of molecular sciences》2022,23(7)
Intervertebral disc (IVD) diseases are common spinal disorders that cause neck or back pain in the presence or absence of an underlying neurological disorder. IVD diseases develop on the basis of degeneration, and there are no established treatments for degeneration. IVD diseases may therefore represent a candidate for the application of regenerative medicine, potentially employing normal human dermal fibroblasts (NHDFs) induced to differentiate into nucleus pulposus (NP) cells. Here, we used a three-dimensional culture system to demonstrate that ectopic expression of MYC, KLF4, NOTO, SOX5, SOX6, and SOX9 in NHDFs generated NP-like cells, detected using Safranin-O staining. Quantitative PCR, microarray analysis, and fluorescence-activated cell sorting revealed that the induced NP cells exhibited a fully differentiated phenotype. These findings may significantly contribute to the development of effective strategies for treating IVD diseases. 相似文献
4.
Mariusz Ł. Mamiński Sylwia Witek Karolina Szymona Paweł Parzuchowski 《Holz als Roh- und Werkstoff》2013,71(2):267-275
Two hyperbranched polyglycerols bearing 1,1,1-tris(hydroxymethyl)propane or Bisphenol A core and terminal hydroxyl functionality were examined as components of novel wood adhesive systems. Two 1,3-dimethylol-4,5-dihydroxyethyleneurea resins (DMDHEU) were used as crosslinkers. Shear strength tests revealed that the adhesives containing up to 75 wt% of renewable glycerol-derived polyglycerols retained performance comparable to that of neat DMDHEU. The results give way to extending the area of application of hyperbranched polyglycerols in the field of wood adhesives. 相似文献
5.
Mehmet Salih Mami? 《International Journal of Electrical Power & Energy Systems》2011,33(7):1256-1261
A non-iterative algorithm based on nodal equation formulation is proposed for transient simulation of nonlinear and time-varying elements. Terminal equations of inductors and capacitors are transformed into algebraic equations using the trapezoidal rule of integration by treating all nonlinear elements as linear and nodal equations are formulated as a set of algebraic equations. LU factorization is used for the solution of nodal equations. Variation of system elements is represented by renewing the nodal conductance matrix at each time step of the solution accordingly. In the first illustrative example, a nonlinear oscillator circuit is considered. In the second, the transient response of a transmission line with a surge arrester is computed by including the corona effects and in the third, a time-dependent primary arc model of a faulty transmission line is examined. Obtained results are compared with those obtained using EMTP and state-space method. Change of simulation time with respect to the step length of the numerical integration is also investigated. 相似文献
6.
Inside Cover: Onocerin Biosynthesis Requires Two Highly Dedicated Triterpene Cyclases in a Fern Lycopodium clavatum (ChemBioChem 4/2016) 下载免费PDF全文
7.
Yuzo Nishida Satoshi Nishino Li Li Guo Mami Kunita Hideaki Matsushima Tadashi Tokii 《Inorganic chemistry communications》1999,2(12):160
We have observed that binuclear cobalt(II) compounds with H(HPTP), Co2(HPTP)(CH3COO)(ClO4)2 and Co2(HPTP)Cl(ClO4)2, react with oxygen molecules when DNA is present in the solution, cleaving the DNA (H(HPTP) denotes N,N,N′,N′-tetrakis(2-pyridylmethyl)-1,3-diaminopropane-2- ol). 相似文献
8.
Hiroshi Kanbe Mami Hirose Tatsuya Ito Masafumi Taniwaki 《Journal of Electronic Materials》2010,39(8):1248-1255
Ge/Si heterojunctions formed by wet wafer bonding were observed using transmission electron microscopy and energy-dispersive
x-ray spectroscopy. For the samples annealed at 880°C, there was a transition layer at the heterointerface with modified regions
in the Si and Ge extending 20 nm to 30 nm from the interface. In these modified regions, crystal defects were observed, and
a large amount of Ge was detected on the Si side of the junction. For the samples annealed at 250°C or 350°C, the transition
layers had an amorphous-like structure with a thickness of about 10 nm. No modified layer or enlargement of lattice spacing
was observed. 相似文献
9.
Uematsu Y Ogimoto M Kabashima J Suzuki K Kaneko R Funayama K Haneishi N Yasuno T Ogino S 《Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan》2005,46(4):133-138
Migration from multi-layer laminated film pouches intended for retort foods was investigated through HPLC analysis with a fluorescence detector, and measurements of residue on evaporation, consumption of potassium permanganate and total organic carbon. HPLC analysis revealed that the levels of migrants in oil and the water which were heated in the pouches (121 degrees C, 30 min) were ten times of those in the corresponding official simulants under the official conditions; n-heptane (25 degrees C, 60 min), and water (95 degrees C, 30 min). Bisphenol A diglycidyl ether and related compounds were found in the oil and the water heated in the pouches, as well as in the simulants. These compounds were thought to have been present in the adhesive between the laminated films, and migrated through the food-contact film of the package. Consumption of potassium permanganate and residue on evaporation of the heated water were ten times of those of the water simulant, while the total organic carbon level of the heated water was several-hold greater than that of the water simulant. In addition, migrant levels per surface area of the pouch were one-fourth of the concentrations per content volume of the pouch. Since compliance with the legal limits is evaluated based on the concentration per surface area, real migration into foods would be underestimated by a factor of another four. 相似文献
10.
M. ?. Mamiński M. E. Król M. Grabowska P. G?uszyński 《Holz als Roh- und Werkstoff》2011,47(6):505-506
A formaldehyde-free adhesive based on urea (U) and glutaraldehyde (GA) was developed. High reactivity of the urea-glutaraldehyde
mix at ambient temperature allows for its cold setting. The glues of GA/U molar ratio between 0.8 and 1.2 were examined. It
was found that for the satisfactory performance of the system, blending with nano-Al2O3 was necessary. 相似文献