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排序方式: 共有1794条查询结果,搜索用时 218 毫秒
1.
Abidur Rahman Makoto Kobayashi Kotaro Sugimoto Yuta Endo Manabu Kojima Shigenori Furukawa Takafumi Watanabe Shu Soeda Yuko Hashimoto Keiya Fujimori Hideki Chiba 《International journal of molecular sciences》2021,22(7)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases. 相似文献
2.
Koji Morita Byung-Nam Kim Hidehiro Yoshida Keijiro Hiraga Yoshio Sakka 《Journal of the European Ceramic Society》2018,38(6):2588-2595
Carbon contamination from the carbon paper/dies during spark-plasma-sintering (SPS) processing was examined in the MgAl2O4 spinel. The carbon contamination sensitively changes with the heating rate during the SPS processing. At the high heating rate of 100 °C/min, the carbon contamination having organized structures occurred over almost the entire area from the surface to deep inside the SPSed spinel disk. In contrast, at the slow heating rate of 10 °C/min, the carbon contamination having disordered structures occurred only around the surface area. The carbon phases transform into high pressure CO/CO2 gases by post-annealing in air and lead to pore formation along the grain junctions. The pore formation significantly occurs at the high heating rate due to the large amount of the contaminant carbon phases. This suggests that if once the carbon contamination was formed in the materials, it is very difficult to remove the carbon phases from the materials. 相似文献
3.
In a healthy 49-year-old man, a decrease in job efficiency was noticed along with bizarre behavior. On admission, he was euphoric, childish, superficial and had increased libido. Neurological findings were normal. There were no abnormal findings on routine blood tests, hematochemistry or urine analysis. MRI showed no abnormal findings. However, single photon emission CT (SPECT) showed diffuse hypoaccummulation of tracer from the temporal to frontal regions. Lumbar puncture showed clear cerebrospinal fluid (CSF) with pleocytosis and an elevated protein level. Moreover, antibody IgG titers to herpes simplex virus (HSV) and measles virus were elevated, according to EIA [serum HSV -1,202.2x, measles virus 47.1x: CSF HSV-116.1x, measles virus 9.9x]. The ratio of serum to CSF antibody titers of HSV and measles virus were 12.5 and 4.75, respectively. The antibody index values of HSV and measles virus IgG titers were 8.42 and 22.22. The ratio of albumin was 105.7. Chronic, progressive HSV encephalitis is rare, and there have been very few reports of encephalitis due to double infection by HSV and another virus. Our patient was diagnosed as having encephalitis due to double infection with HSV and measles virus, because the ratio of serum to CSF antibody titers was less than 20 and the antibody index values were over 1.91. Moreover, since the IgG index was elevated and the ratio of albumin was not low, it was suggested that the blood-brain-barrier had not been disrupted, and antibodies were being produced chronically in the medullary cavity. Hyperaccummulation of tracer on SPECT studies has been reported in the early stages of HSV encephalitis. In our case, while CT and MRI showed no abnormal findings, SPECT showed diffuse hypoaccummulation. SPECT appears to be a useful tool in the diagnosis of this disorder. In case of chronic, progressive personality change in middle-aged adults, we must be aware of double virus infection of the brain as a possible causal factor. 相似文献
4.
5.
Manabu Iguchi Tsuneo Kondoh Keiji Nakajima 《Metallurgical and Materials Transactions B》1997,28(4):605-612
The establishment time of gas-liquid two-phase flows in a cylindrical bath agitated by bottom gas injection through a central
single-hole bottom nozzle was investigated. Because the turbulence intensity in the bath was comparable to or larger than
the unity, the conventional definition of the flow establishment time based on the history of mean velocity was not suitable
for the present case. In fact, it was difficult to determine the flow establishment time based on the well-known 90 or 99
pct criterion for the mean velocity. Accordingly, two methods of determining the flow establishment time by focusing on the
turbulence components instead of the mean velocity components were proposed. Velocity measurements were made with a two-channel
laser Doppler velocimeter. The flow establishment time was correlated as a function of gas flow rate. Close agreement was
obtained by the two methods. 相似文献
6.
K Endo K Morita Y Uchiyama K Takada A Tsujimoto T Dohi 《Canadian Metallurgical Quarterly》1993,62(3):325-328
Influences of drug-induced manipulations of central serotonergic function on lidocaine- and pentylenetetrazol (PTZ)-induced convulsions were examined in mice. Agents that suppressed serotonergic transmission increased, whereas drugs that facilitated serotonin (5-HT) function decreased the incidence of lidocaine-induced convulsions. These treatments had similar influences on the incidence of PTZ-induced convulsions. Lidocaine (10(-5)-10(-3) M) reduced the stimulation evoked [3H]5-HT release from cortical slices, followed with an increased spontaneous [3H] overflow at higher concentrations. These results may suggest that brain 5-HT neurons are causally involved as inhibitory neurons in lidocaine-induced convulsions as in the case of PTZ-induced convulsions. 相似文献
7.
Boron removal by titanium addition in solidification refining of silicon with Si-Al melt 总被引:4,自引:0,他引:4
Takeshi Yoshikawa Kentaro Arimura Kazuki Morita 《Metallurgical and Materials Transactions B》2005,36(6):837-842
In order to effectively remove B from Si for its use in solar cells, a process involving B removal by solidification refining
of Si using a Si-Al melt with Ti addition was investigated. For clarifying the effect of Ti addition on B removal from the
Si-Al melt, TiB2 solubilities in Si-64.6 at. pct Al melt at 1173 K and Si-60.0 at. pct Al melt at 1273 K were determined by measuring the
equilibrium concentrations of B and Ti in the presence of TiB2 precipitates. The small solubilities of TiB2 in the Si-Al melt indicate the effective removal of B from the Si-Al melt by Ti addition. Further, solidification experiments
of Si-Al alloys containing B by Ti addition were performed, and the effect of Ti addition on the solidification refining of
Si with the Si-Al melt was successfully confirmed. 相似文献
8.
Shuzo Kuwano Manabu Ishihara 《The Journal of microwave power and electromagnetic energy》2007,40(3):155-164
The finite-difference time-domain (FDTD) simulations of specific absorption rate (SAR) in a human head exposed to microwaves have, to date, been carried out on models of the head only. This was because it was believed that the body effects on the average SAR of the head could be ignored at high frequencies of around 1 GHz. That opinion, however, was based on inappropriate calculation conditions and is therefore unreliable. In this paper, we have re-examined the body effects on the SAR distributions in a realistic homogeneous model of the adult head exposed to microwaves. We found that the SAR on the eye surface of the head-only model exposed to E-polarized waves was 31% smaller than that of the whole-body model at 900 MHz, and 43% larger at 1.5 GHz. For a size that can practically be considered whole-body, it is necessary to have the top of the head to the belly for 900 MHz and to the chest area for 1.5 GHz. The previously unclear body effects of H-polarized waves were assumed to be less than those of E-polarized waves, suggesting that the chest area would be sufficient for both frequencies. 相似文献
9.
10.
On‐Line Detection Of State‐Of‐Charge In Lead Acid Battery Using Radial Basis Function Neural Network
To realize a stable supply of electric power in an automobile, an accurate and reliable detection method of SOC (state‐of‐charge) in a lead acid battery is required. However the dynamics of the battery is very complicated. The characteristics of the battery greatly change due to its degradation. Moreover a automobile has many driving patterns, which are unknown beforehand. Thus it is not easy to detect the SOC analytically. In this paper, to overcome this problem, a new on‐line SOC detection method with a radial basis function neural network is proposed. In order to increase the detection accuracy of degraded batteries, physical values related to the degradation degree are used as input signal in the neural network. The detection accuracies for different sized batteries and various degradation states are investigated. 相似文献