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Bewertung von Abfallbehandlungsverfahren: Entscheidungsunterstützung durch die neue VDI‐Richtline 3925 下载免费PDF全文
The new VDI guideline 3925 presents assessment tools for the comparison of economic, ecological and also social aspects of different waste treatment processes. Objective of the guideline is to describe the application of suitable scientific and technical assessment methods to waste management strategies. The methods, their applicability, complexity, opportunities and limits are illustrated using practical examples. 相似文献
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Görmen M Pigeon P Top S Hillard EA Huché M Hartinger CG de Montigny F Plamont MA Vessières A Jaouen G 《ChemMedChem》2010,5(12):2039-2050
Herein we report the antiproliferative effects of a series of 28 compounds against the MDA-MB-231 breast cancer cell line, including the synthesis of seven new [3]ferrocenophanyl and four new ferrocenyl compounds. For each p-R-phenyl substitution pattern investigated, the [3]ferrocenophanyl derivatives were more cytotoxic than the corresponding ferrocenyl derivative, with the highest activity found for compounds with protic substituents. Theoretical calculations of the HOMO-LUMO gap for the molecules in the Fe3(+) oxidation state suggest a higher reactivity for the [3]ferrocenophanyl derivatives. A lead compound from each series, a [3]ferrocenophanyl and a ferrocenyl compound, possessing two phenol groups, were screened against the NCI/DTP 60-cell-line panel. The mean activity over all cell lines was better than cisplatin for both compounds, and both compounds showed subpanel selectivity for leukemia, CNS cancer, and renal cancer. Low systemic toxicity and lack of interaction with DNA (when in the reduced form), suggest that the compounds may act as prodrugs. 相似文献
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Vessières A Spera D Top S Misterkiewicz B Heldt JM Hillard E Huché M Plamont MA Napolitano E Fiaschi R Jaouen G 《ChemMedChem》2006,1(11):1275-1281
We recently reported the dual (antihormonal and cytotoxic) functionality of ferrocifens, which are organometallic complexes derived from hydroxytamoxifen, the standard molecule in the treatment of hormone-dependent breast cancers. To test the hypothesis that the presence of a ferrocenyl substituent on molecules with an affinity for the estrogen receptor is sufficient to give them cytotoxic properties in vitro, we prepared complexes derived from estradiol with a ferrocenyl substituent at positions 7alpha and 17alpha. The complexes thus obtained retain a satisfactory level of affinity for the estrogen receptor (RBA values higher than 12 %). At low concentrations (0.1-1 microM) the complexes show an estrogenic effect in vitro equivalent to that of estradiol on hormone-dependent (MCF-7) breast cancer cells, and no cytotoxic effect on hormone-independent (MDA-MB-231) breast cancer cells. At high concentrations (up to 50 microM) the 17alpha-ethynylferrocenyl estradiol and 7alpha-ferrocenylmethylthio estradiol become cytotoxic (IC(50)=13.2 microM and 18.8 microM, respectively) while the 17alpha-ferrocenylestradiol remains non toxic. The low toxicity of these compounds support our hypothesis that electronic communication between the ferrocenyl and phenol moieties in the hydroxyferrocifens series is a key parameter in the generation of cytotoxic effects at submicromolar concentrations. 相似文献
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Ivan Lillamand Jean-François Chaix Marie-Aude Ploix Vincent Garnier 《NDT & E International》2010,43(8):655-660
This study deals with the general matter of non-destructive evaluation of pre-stressed structures in civil engineering. Usually such structures are composed of concrete and are steel reinforced. Proposed idea is the evaluation of mechanical stress state of a concrete body (instead of steel cables) via ultrasonic non-destructive evaluation (NDE), by using the link between ultrasonic velocities and mechanical stresses provided by the acoustoelasticity theory. Velocities of the ultrasonic waves (longitudinal and transversal with different polarizations) are observed during propagation through a concrete body submitted to uni-axial loading (compressive testing). Obvious variations in velocity are found depending on the mechanical stress state (e.g. Δc=92 m/s at σ=16 MPa for longitudinal waves). Thus acoustoelastic behavior of concrete is demonstrated. Further analyses provide acoustoelastic coefficients of concrete about ten times higher than the common ones of steel. The feasibility of stress evaluation using ultrasounds in concrete structures is proved under laboratory conditions. 相似文献
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van Agthoven MA Chiron L Coutouly MA Delsuc MA Rolando C 《Analytical chemistry》2012,84(13):5589-5595
2D FT-ICR MS allows the correlation between precursor and fragment ions by modulating ion cyclotron radii for fragmentation modes with radius-dependent efficiency in the ICR cell without the need for prior ion isolation. This technique has been successfully applied to ion-molecule reactions, Collision-induced dissociation and infrared multiphoton dissociation. In this study, we used electron capture dissociation for 2D FT-ICR MS for the first time, and we recorded two-dimensional mass spectra of peptides and a mixture of glycopeptides that showed fragments that are characteristic of ECD for each of the precursor ions in the sample. We compare the sequence coverage obtained with 2D ECD FT-ICR MS with the sequence coverage obtained with ECD MS/MS and compare the sensitivities of both techniques. We demonstrate how 2D ECD FT-ICR MS can be implemented to identify peptides and glycopeptides for proteomics analysis. 相似文献
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Tiberj A Huntzinger JR Camassel J Hiebel F Mahmood A Mallet P Naud C Veuillen JY 《Nanoscale research letters》2011,6(1):171
In this article, a multiscale investigation of few graphene layers grown on 6H-SiC(000-1) under ultrahigh vacuum (UHV) conditions
is presented. At 100-μm scale, the authors show that the UHV growth yields few layer graphene (FLG) with an average thickness
given by Auger spectroscopy between 1 and 2 graphene planes. At the same scale, electron diffraction reveals a significant
rotational disorder between the first graphene layer and the SiC surface, although well-defined preferred orientations exist.
This is confirmed at the nanometer scale by scanning tunneling microscopy (STM). Finally, STM (at the nm scale) and Raman
spectroscopy (at the μm scale) show that the FLG stacking is turbostratic, and that the domain size of the crystallites ranges
from 10 to 100 nm. The most striking result is that the FLGs experience a strong compressive stress that is seldom observed
for graphene grown on the C face of SiC substrates. 相似文献
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