Affine reconstruction from perspective image pairs with a relativeobject-camera translation in between

A method is described to recover the three-dimensional affine structure of a scene consisting of at least five points identified in two perspective views with a relative object-camera translation in between. When compared to the results for arbitrary stereo views, a more detailed reconstruction is possible using less information. The method presented only assumes that the two images are obtained by identical cameras, but no knowledge about the intrinsic parameters of the camera(s) or about the performed translation is assumed. By the same method, affine 3D reconstruction from a single view can be achieved for parallel structures. In that case, four points suffice for affine reconstruction     

Autism-friendly architecture from the outside in and the inside out: an explorative study based on autobiographies of autistic people

Researchers and designers each developed a particular vision on autism-friendly architecture. Because the basis of this vision is not always clear, questions arise about its meaning and value and about how it can be put to use. People with a diagnosis on the autism spectrum are central to these questions, yet risk to disappear from the picture. Refocusing the discourse about autism-friendly architecture on them was the aim of the explorative study reported here. Six autobiographies written by autistic (young) adults were analysed from two different viewpoints. First, concepts from design guidelines concerning autism-friendly architecture were confronted with fragments from these autobiographies. The second part of the analysis started from the autobiographies themselves. This analysis shows that concepts can be interpreted in multiple ways. They can reinforce but also counteract each other, thus asking for critical judgment. An open space is preferred by some autistic people because it affords having an overview, which increases predictability, and distancing oneself from others without being isolated. Others might like this space to be subdivided into several separate spaces, which affords a sense of structure or reduces sensory inputs present in one room. The six autobiographies provide a glimpse of autistic people’s world of experience. Analysing these is a first step in revealing what architecture can actually mean from their point of view. For them, the material environment has a prominent meaning that is, however, not always reducible to design guidelines. It offers them something to hold on to, relate to or structure their reality.     

Heads or Tails: Genotyping of Hepatitis C Virus Concerning the 2k/1b Circulating Recombinant Form

As different hepatitis C virus (HCV) genotypes respond differently to initiated therapy, correct HCV genotyping is essential. A potential risk for misclassification of the intergenotypic HCV circulating recombinant form (CRF) 2k/1b strains exists, depending on the genotyping method used. The aim was to investigate the differences in HCV genotyping methods with regard to CRF 2k/1b and to gain insight in the prevalence of the CRF 2k/1b. Genotyping results by Versant HCV Genotype Assay were compared with nonstructural protein 5B (NS5B) sequencing. In total, from November 2001 until March 2015, 3296 serum samples were analyzed by Versant HCV Genotype Assay. As misclassified CRF is harbored among HCV genotype 2, we further focused our search on 142 (4.3%) samples positive for HCV genotype 2. On 116 (81.7%) retrieved samples, the NS5B sequencing was performed. Twelve out of the 116 retrieved samples (10.3%) were classified as CRF 2k/1b by sequencing of the NS5B region. Ten of these 12 samples were originally misclassified as genotype 2a or 2c, while 2 of them were misclassified as genotype 2. Our results show that the current prevalence of CRF 2k/1b is underestimated. The importance of correct HCV genotyping is emphasized, considering the tailored choice of treatment regimen and overall prognosis.     

Realistic speech animation based on observed 3D face dynamics

An efficient system for realistic speech animation is proposed. The system supports all steps of the animation pipeline, from the capture or design of 3D head models up to the synthesis and editing of the performance. This pipeline is fully 3D, which yields high flexibility in the use of the animated character. Real detailed 3D face dynamics, observed at video frame rate for thousands of points on the face of speaking actors, underpin the realism of the facial deformations. These are given a compact and intuitive representation via independent component analysis (ICA). Performances amount to trajectories through this 'viseme space'. When asked to animate a face, the system replicates the 'visemes' that it has learned, and adds the necessary coarticulation effects. Realism has been improved through comparisons with motion captured groundtruth. Faces for which no 3D dynamics have been observed can be animated nonetheless. Their visemes are adapted automatically to their physiognomy by localising the face in a 'face space'.     

Immunological Properties of Inulin-Type Fructans

Beneficial effects of inulin-type fructans are discussed in view of studies that applied the oligosaccharides in colon cancer, chronic inflammatory diseases, vaccination efficacy, and prevention of infection and allergy. In the present paper, we discuss their immunomodulating effects. It is suggested that immunomodulation is elicited through indirect and direct mechanisms. Indirect mechanisms encompass stimulation of growth and activity of lactic acid bacteria, but can also be caused by fermentation products of these bacteria, i.e., short chain fatty acids. Evidence for direct effects on the immune system generally remains to be confirmed. It is suggested that inulin-type fructans can be detected by gut dendritic cells (DCs), through receptor ligation of pathogen recognition receptors (PRRs) such as Toll-like receptors, nucleotide oligomerization domain containing proteins (NODs), C-type lectin receptors, and galectins, eventually inducing pro- and anti-inflammatory cytokines. DCs may also exert antigen presenting capacity toward effector cells, such as B cells, T cells, and natural killer cells locally, or in the spleen. Inulin-type fructans may also ligate PRRs expressed on gut epithelium, which could influence its barrier function. Inulin-type fructans are potent immunomodulating food components that hold many promises for prevention of disease. However, more studies into the mechanisms, dose-effect relations, and structure-function studies are required.     

Visual word recognition in bilinguals: Evidence from masked phonological priming.

Bilingual written language representation was investigated with the masked phonological priming paradigm. Pseudohomophonic and control primes of French target words were used to show that Dutch–French bilinguals exhibit the same pattern of phonological and orthographic priming as native French speakers, which suggests that the same processes underlie first- and second-language processing. It was also found that for bilinguals, but not monolinguals, it is possible to prime a target word of the second language with a homophonic stimulus (either word or nonword) of the first language. This interlingual phonological priming effect was of the same size as the intralingual priming effect. Implications for theories of bilingual written language representation and for the interpretation of the masked phonological priming paradigm are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adult Parasitoids of Honeydew-Producing Insects Prefer Honeydew Sugars to Cover their Energetic Needs

To meet their carbohydrate requirements, adult parasitoids exploit a broad range of sugar resources, including floral and extrafloral nectar and honeydew. Although honeydew might be the predominant sugar source, especially in agricultural systems, it often is nutritionally inferior to sugar sources like nectar. Given its broad availability, it may be expected that sugar-feeding insects have evolved specialized adaptations to deal with this typically inferior sugar source. This would apply especially to organisms that have a close association with honeydew producers. Here, we hypothesized that parasitoids of honeydew-producing insects should show a pronounced response to sugars, such as fructose, sucrose, melezitose, and trehalose, and to a lesser extent glucose. To test this hypothesis, we investigated sugar consumption, feeding behavior and survival of the aphid parasitoid Aphidius ervi on several sugars (equiweight solutions). Our results show that A. ervi adults consumed typical honeydew sugars (sucrose, fructose, trehalose, and melezitose) the most, while consuming considerably less glucose or melibiose. Rhamnose, which does not occur in aphid honeydew, was not, or was only marginally, consumed. When different sugars were provided at the same time, A. ervi adults preferred sucrose or fructose over glucose or melezitose. Furthermore, pre-exposure to sucrose or fructose significantly reduced subsequent intake of glucose, suggesting an acquired distaste for glucose after being previously exposed to highly preferred sugars such as sucrose and fructose. Altogether, this study shows that A. ervi adults prefer sugars (fructose, melezitose, trehalose, and sucrose) that are overrepresented in aphid honeydew and show a lower preference to one (glucose) that is underrepresented in honeydew.     

Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment

Current antiplatelet drugs for the treatment of arterial thrombosis often coincide with increased bleeding risk. Several tyrosine kinase inhibitors (TKIs) for cancer treatment inhibit platelet function, with minor reported bleeding symptoms. The aim of this study was to compare the antiplatelet properties of eight TKIs to explore their possible repurposing as antiplatelet drugs. Samples of whole blood, platelet-rich plasma (PRP), or isolated platelets from healthy donors were treated with TKI or the vehicle. Measurements of platelet aggregation, activation, intracellular calcium mobilization, and whole-blood thrombus formation under flow were performed. Dasatinib and sunitinib dose-dependently reduced collagen-induced aggregation in PRP and washed platelets; pazopanib, cabozantinib, and vatalanib inhibited this response in washed platelets only; and fostamatinib, axitinib, and lapatinib showed no/limited effects. Fostamatinib reduced thrombus formation by approximately 50% on collagen and other substrates. Pazopanib, sunitinib, dasatinib, axitinib, and vatalanib mildly reduced thrombus formation on collagen by 10–50%. Intracellular calcium responses in isolated platelets were inhibited by dasatinib (>90%), fostamatinib (57%), sunitinib (77%), and pazopanib (82%). Upon glycoprotein-VI receptor stimulation, fostamatinib, cabozantinib, and vatalanib decreased highly activated platelet populations by approximately 15%, while increasing resting populations by 39%. In conclusion, the TKIs with the highest affinities for platelet-expressed molecular targets most strongly inhibited platelet functions. Dasatinib, fostamatinib, sunitinib, and pazopanib interfered in early collagen receptor-induced molecular-signaling compared with cabozantinib and vatalanib. Fostamatinib, sunitinib, pazopanib, and vatalanib may be promising for future evaluation as antiplatelet drugs.