排序方式: 共有23条查询结果,搜索用时 15 毫秒
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Fabio Maria Sabbatini Dr. Romano Di Fabio Dr. Mauro Corsi Dr. Paolo Cavanni Dr. Steve M. Bromidge Dr. Yves St‐Denis Dr. Lucilla D'Adamo Dr. Marilisa Rinaldi Dr. Chiara Savoia Dr. Claudia Mundi Dr. Benedetta Perini Dr. Andrew J. Carpenter Dr. Giovanna Dal Forno Dr. Federico Faggioni Dr. Michela Tessari Dr. Francesca Pavone Dr. Alberto Buson Dr. Mario Mattioli Dr. Elisabetta Perdona' Dr. Sergio Melotto Dr. 《ChemMedChem》2010,5(9):1450-1455
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Impact of diet supplemented with microencapsulated condensed tannins on cow milk nutritional profile
Attilio Matera Lucia Sepe Silvia Vincenzetti Roberta Tolve Nicola Condelli Salvatore Claps Francesco Genovese Annamaria Ricciardi Teresa Zotta Teresa Scarpa Maria Antonietta Di Napoli Giulia Francesca Cifuni Paolo Polidori Giuseppe Santini Luciano Scarano Giuseppe Altieri Giovanni Carlo Di Renzo Sofia Renzi Marilisa Giavalisco Fernanda Galgano 《International Journal of Dairy Technology》2023,76(4):813-827
Feed production systems should consider more sustainable solutions to reduce the pressure on earth's finite resources. In this work, we investigated the effect of microencapsulated condensed tannins (MCTs)-enhanced diet on the cow milk characteristics. The diet reduced the urea content, while preserved and the n-3 and n-6 portion of fatty acids. Aside from the rising of vitamin C level, MCTs had a negative effect on the amount of B group vitamins. MCTs may be considered a promising feed supplement that offers a good trade-off in terms of milk chemical quality while increasing the environmental sustainability of cattle livestock. 相似文献
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Paolo Colomba Simona Fontana Giuseppe Salemi Marilisa Barranca Claudia Lo Sicco Maria Antonietta Mazzola Paolo Ragonese Giovanni Savettieri Giacomo De Leo Riccardo Alessandro Giovanni Duro 《International journal of molecular sciences》2014,15(12):23269-23282
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. At present, the molecular mechanisms causing the initiation, development and progression of MS are poorly understood, and no reliable proteinaceous disease markers are available. In this study, we used an immunoproteomics approach to identify autoreactive antibodies in the cerebrospinal fluid of MS patients to use as candidate markers with potential diagnostic value. We identified an autoreactive anti-transferrin antibody that may have a potential link with the development and progression of MS. We found this antibody at high levels also in the serum of MS patients and created an immunoenzymatic assay to detect it. Because of the complexity and heterogeneity of multiple sclerosis, it is difficult to find a single marker for all of the processes involved in the origin and progression of the disease, so the development of a panel of biomarkers is desirable, and anti-transferrin antibody could be one of these. 相似文献
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Targeting EphA2‐Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues 下载免费PDF全文
Dr. Flavia A. Mercurio Dr. Daniela Marasco Dr. Concetta Di Natale Dr. Luciano Pirone Dr. Susan Costantini Dr. Emilia M. Pedone Dr. Marilisa Leone 《Chembiochem : a European journal of chemical biology》2016,17(22):2179-2188
The EphA2 receptor controls diverse physiological and pathological conditions and its levels are often upregulated in cancer. Targeting receptor overexpression, through modulation of endocytosis and consequent degradation, appears to be an appealing strategy for attacking tumor malignancy. In this scenario, the Sam domain of EphA2 plays a pivotal role because it is the site where protein regulators of endocytosis and stability are recruited by means of heterotypic Sam–Sam interactions. Because EphA2‐Sam heterotypic complexes are largely based on electrostatic contacts, we have investigated the possibility of attacking these interactions with helical peptides enriched in charged residues. Several peptide sequences with high predicted helical propensities were designed, and detailed conformational analyses were conducted by diverse techniques including NMR, CD, and molecular dynamics (MD) simulations. Interaction studies were also performed by NMR, surface plasmon resonance (SPR), and microscale thermophoresis (MST) and led to the identification of two peptides capable of binding to the first Sam domain of Odin. These molecules represent early candidates for the generation of efficient Sam domain binders and antagonists of Sam–Sam interactions involving EphA2. 相似文献
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