排序方式: 共有34条查询结果,搜索用时 31 毫秒
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María del Mar Noblejas-Lpez Mariona Baliu-Piqu Cristina Nieto-Jimnez Francisco J. Cimas Esther C. Morafraile Atanasio Pandiella ngel L. Corbi Balzs Gyrffy Alberto Ocaa 《International journal of molecular sciences》2021,22(8)
Targeting the innate immune system has attracted attention with the development of anti- CD47 antibodies. Anti-CD47 antibodies block the inhibition of the phagocytic activity of macrophages caused by the up-regulation of CD47 on tumor cells. In this study, public genomic data was used to identify genes highly expressed in breast tumors with elevated CD47 expression and analyzed the association between the presence of tumor immune infiltrates and the expression of the selected genes. We found that 142 genes positively correlated with CD47, of which 83 predicted favorable and 32 detrimental relapse-free survival (RFS). From those associated with favorable RFS, we selected the genes with immunologic biological functions and defined a CD47-immune signature composed of PTPRC, HLA-E, TGFBR2, PTGER4, ETS1, and OPTN. In the basal-like and HER2+ breast cancer subtypes, the expression of the CD47-immune signature predicted favorable outcome, correlated with the presence of tumor immune infiltrates, and with gene expression signatures of T cell activation. Moreover, CD47 up-regulated genes associated with favorable survival correlated with pro-tumoral macrophages. In summary, we described a CD47-immune gene signature composed of 6 genes associated with favorable prognosis, T cell activation, and pro-tumoral macrophages in breast cancer tumors expressing high levels of CD47. 相似文献
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Nima Taghipour Mariona Dalmases Guy L. Whitworth Miguel Dosil Andreas Othonos Sotirios Christodoulou Shanti Maria Liga Gerasimos Konstantatos 《Advanced materials (Deerfield Beach, Fla.)》2023,35(1):2207678
The use of colloidal quantum dots (CQDs) as a gain medium in infrared laser devices has been underpinned by the need for high pumping intensities, very short gain lifetimes, and low gain coefficients. Here, PbS/PbSSe core/alloyed-shell CQDs are employed as an infrared gain medium that results in highly suppressed Auger recombination with a lifetime of 485 ps, lowering the amplified spontaneous emission (ASE) threshold down to 300 µJ cm−2, and showing a record high net modal gain coefficient of 2180 cm−1. By doping these engineered core/shell CQDs up to nearly filling the first excited state, a significant reduction of optical gain threshold is demonstrated, measured by transient absorption, to an average-exciton population-per-dot 〈Nth〉g of 0.45 due to bleaching of the ground state absorption. This in turn have led to a fivefold reduction in ASE threshold at 〈Nth〉ASE = 0.70 excitons-per-dot, associated with a gain lifetime of 280 ps. Finally, these heterostructured QDs are used to achieve near-infrared lasing at 1670 nm at a pump fluences corresponding to sub-single-exciton-per-dot threshold (〈Nth〉Las = 0.87). This work brings infrared CQD lasing thresholds on par to their visible counterparts, and paves the way toward solution-processed infrared laser diodes. 相似文献
3.
Albert Rimola Piero Ugliengo Mariona Sodupe 《International journal of molecular sciences》2009,10(3):746-760
The condensation (polymerization by water elimination) of molecular building blocks to yield the first active biopolymers (e.g. of amino acids to form peptides) during primitive Earth is an intriguing question that nowadays still remains open since these processes are thermodynamically disfavoured in highly dilute water solutions. In the present contribution, formation and hydrolysis of glycine oligopeptides occurring on a cluster model of sanidine feldspar (001) surface have been simulated by quantum mechanical methods. Results indicate that the catalytic interplay between Lewis and Brønsted sites both present at the sanidine surface, in cooperation with the London forces acting between the biomolecules and the inorganic surface, plays a crucial role to: i) favour the condensation of glycine to yield oligopeptides as reaction products; ii) inhibit the hydrolysis of the newly formed oligopeptides. Both facts suggest that mineral surfaces may have helped in catalyzing, stabilizing and protecting from hydration the oligopeptides formed in the prebiotic era. 相似文献
4.
Santanu Pradhan Mariona Dalmases Ayse‐Bilgehan Baspinar Gerasimos Konstantatos 《Advanced functional materials》2020,30(39)
Unbalanced charge injection is deleterious for the performance of colloidal quantum dot (CQD) light‐emitting diodes (LEDs) as it deteriorates the quantum efficiency, brightness, and operational lifetime. CQD LEDs emitting in the infrared have previously achieved high quantum efficiencies but only when driven to emit in the low‐radiance regime. At higher radiance levels, required for practical applications, the efficiency decreased dramatically in view of the notorious efficiency droop. Here, a novel methodology is reported to regulate charge supply in multinary bandgap CQD composites that facilitates improved charge balance. The current approach is based on engineering the energetic potential landscape at the supra‐nanocrystalline level that has allowed to report short‐wave infrared PbS CQD LEDs with record‐high external quantum efficiency in excess of 8%, most importantly, at a radiance level of ≈5 W sr?1 m2, an order of magnitude higher than prior reports. Furthermore, the balanced charge injection and Auger recombination reduction has led to unprecedentedly high operational stability with radiance half‐life of 26 068 h at a radiance of 1 W sr?1 m?2. 相似文献
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Supply chain network design aims at the integration of the different actors of a supply chain within a single framework in order to optimise the total profit of the system. In this paper, we consider the integration of line balancing issues within the tactical decisions of the supply chain, and we offer a novel model and a solution approach for the problem. The new approach decomposes the problem into multiple line balancing problems and a mixed integer linear model, which is easier to solve than the previously available non-linear mixed integer formulation. The results show that the new method is able to solve previously studied models within a fraction of the reported running times, and also allows us to solve larger instances than those reported in earlier works. Finally, we also provide some analysis on the influence of the cost structure, the demand and the structure of the assembly process on the final configuration of the assemblies and the distribution network. 相似文献
7.
Mariona?TauléEmail author Aina?Peris Horacio?Rodríguez 《Language Resources and Evaluation》2016,50(3):549-584
This article presents the Spanish Iarg-AnCora corpus (400 k-words, 13,883 sentences) annotated with the implicit arguments of deverbal nominalizations (18,397 occurrences). We describe the methodology used to create it, focusing on the annotation scheme and criteria adopted. The corpus was manually annotated and an interannotator agreement test was conducted (81 % observed agreement) in order to ensure the reliability of the final resource. The annotation of implicit arguments results in an important gain in argument and thematic role coverage (128 % on average). It is the first corpus annotated with implicit arguments for the Spanish language with a wide coverage that is freely available. This corpus can subsequently be used by machine learning-based semantic role labeling systems, and for the linguistic analysis of implicit arguments grounded on real data. Semantic analyzers are essential components of current language technology applications, which need to obtain a deeper understanding of the text in order to make inferences at the highest level to obtain qualitative improvements in the results. 相似文献
8.
Santanu Pradhan Mariona Dalmases Gerasimos Konstantatos 《Advanced materials (Deerfield Beach, Fla.)》2020,32(45):2003830
Solid-state broadband light emitters in the visible have revolutionized today's lighting technology achieving compact footprints, flexible form factors, long lifetimes, and high energy saving, although their counterparts in the infrared are still in the development phase. To date, broadband emitters in the infrared have relied on phosphor-downconverted light emitters based on atomic optical transitions in transition metal or rare earth elements in the phosphor layer resulting in limited spectral bandwidths in the near-infrared and preventing their integration into electrically driven light-emitting diodes (LEDs). Herein, phosphor-converted LEDs based on engineered stacks of multi-bandgap colloidal quantum dots (CQDs) are reported as a novel class of broadband emitters covering a broad short-wave infrared (SWIR) spectrum from 1050–1650 nm with a full-width-half-maximum of 400 nm, delivering 14 mW of optical power with a quantum efficiency of 5.4% and power conversion efficiency of 13%. Leveraging the electrical conductivity of the CQD stacks, further, the first broadband SWIR-active LED is demonstrated, paving the way toward complementary metal–oxide–semiconductor integrated broadband emitters for on-chip spectrometers and low-cost volume manufacturing. SWIR spectroscopy is employed to illustrate the practical relevance of the emitters in food and material identification case studies. 相似文献
9.
On the Role of the Sr3−xCaxAl2O6 Sacrificial Layer Composition in Epitaxial La0.7Sr0.3MnO3 Membranes
Pol Salles Roger Guzman Aleix Barrera Martí Ramis Jose Manuel Caicedo Anna Palau Wu Zhou Mariona Coll 《Advanced functional materials》2023,33(41):2304059
The possibility to fabricate freestanding single crystal complex oxide films has raised enormous interest to be integrated in next-generation electronic devices envisaging distinct and novel properties that can deliver unprecedented performance improvement compared to traditional semiconductors. The use of the water-soluble Sr3Al2O6 (SAO) sacrificial layer to detach the complex oxide film from the growth substrate has significantly expanded the complex oxide perovskite membranes library. Nonetheless, the extreme water sensitivity of SAO hinders its manipulation in ambient conditions and restricts the deposition approaches to those using high vacuum. This study presents a pioneering study on the role of Ca-substitution in solution processed SAO (Sr3−xCaxAl2O6 with x ⩽ 3) identifying a noticeable improvement on surface film crystallinity preserving a smooth surface morphology while favoring the manipulation in a less-restricted ambient conditions. Then, the study focuses on the effect of the sacrificial composition on the subsequent ex situ deposition of La0.7Sr0.3MnO3 (LSMO) by pulsed laser deposition, to obtain epitaxial films with a variable degree of strain. Finally, epitaxial and strain-free LSMO membranes with metal-insulator transition at 290 K are delivered. This study offers a hybrid and versatile approach to prepare and easily manipulate crystalline perovskite oxide membranes by facilitating ex situ growth on SAO-based sacrificial layer. 相似文献
10.
Elisabet Navarro-Tapia Laura Almeida-Toledano Giorgia Sebastiani Mariona Serra-Delgado
scar García-Algar Vicente Andreu-Fernndez 《International journal of molecular sciences》2021,22(5)
Anxiety and eating disorders produce a physiological imbalance that triggers alterations in the abundance and composition of gut microbiota. Moreover, the gut–brain axis can be altered by several factors such as diet, lifestyle, infections, and antibiotic treatment. Diet alterations generate gut dysbiosis, which affects immune system responses, inflammation mechanisms, the intestinal permeability, as well as the production of short chain fatty acids and neurotransmitters by gut microbiota, which are essential to the correct function of neurological processes. Recent studies indicated that patients with generalized anxiety or eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorders) show a specific profile of gut microbiota, and this imbalance can be partially restored after a single or multi-strain probiotic supplementation. Following the PRISMA methodology, the current review addresses the main microbial signatures observed in patients with generalized anxiety and/or eating disorders as well as the importance of probiotics as a preventive or a therapeutic tool in these pathologies. 相似文献